Explores the functioning cardiovascular system from an integrative viewpoint. Includes both historical developments and recent findings on the diverse aspects of cardiovascular function. Provides a conceptual framework for understanding cardiovascular function in health, as well as analysis of altered cardiovascular control during illness or under various physical and environmental conditions. Topics are presented from a basic science perspective with relevant implactions for clinical and applied settings offered.

Focuses on exercise and fitness for both healthy individuals and those with conditions such as cardiovascular disease and obesity. The text discusses basic etiology and pathophysiology and details the role of exercise in prevention and rehabilitation. Emphasis is on prescribing effective exercise programs. Presents discussions on etiology of disease, principles of exercise prescription, value of exercise, fitness measurement and more! Includes numerous illustrations and references.

The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health. Table of Contents: Introduction / Anatomy of Skeletal Muscle and Its Vascular Supply / Regulation of Vascular Tone in Skeletal Muscle / Exercise Hyperemia and Regulation of Tissue Oxygenation During Muscular Activity / Microvascular Fluid and Solute Exchange in Skeletal Muscle / Skeletal Muscle Circulation in Aging and Disease States: Protective Effects of Exercise / References

Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

This book reviews the assessment of human performance and the role of different exercise modes both in a laboratory and clinical setting. Details of how to successfully perform basic laboratory procedures for exercise training in health and disease, as well as how to apply non-invasive measurements in exercise physiology are provided. Chapters cover how to appropriately use a range of measures in assessing pulmonary function, anaerobic function and oxygen uptake. Techniques for cardiopulmonary rehabilitation and the mechanisms associated with thermoregulation are also described. Interactive exercises enable readers to easily assimilate key concepts and develop a thorough understanding of the topic. Basic Exercise Physiology provides both trainees and professional healthcare staff interested in exercise physiology with a detailed and practically applicable resource on the topic.

Physical Activity and Health explains clearly, systematically and in detail the relationship between physical activity, health and disease, and examines the role of exercise in the prevention and management of a wide range of important conditions. Now in a fully updated and expanded third edition, this is the most complete and engaging textbook on the subject. It offers a balanced examination of the latest evidence linking levels of physical activity with the risk of mortality, cardiovascular diseases, diabetes, obesity, cancer, osteoporosis and dementia. Designed to help the reader evaluate the quality of the evidence, the book includes an invaluable discussion of common study designs and the inherent difficulties of measuring physical activity. It examines the evidence in relation to child and adolescent health, older adults, hazards of exercise, sedentary behaviour, public health policy and, in a new chapter, mental health, and an epilogue considers the emerging evidence regarding the significance of physical activity and COVID-19. Containing chapter summaries, study tasks, guides to supplementary reading, a glossary of key terms and an abundance of figures and tables, Physical Activity and Health is an essential course text, and important reading for undergraduate, masters and postgraduate research students of sport and exercise science, public health, physical therapy, medicine and nursing. This third edition is supported by an updated companion website featuring self-test questions, PowerPoint slides, learning activities and website links.

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

This new edition of Exercise and the Heart in Health and Disease greatly advances the details of the first edition, expanding the amount of data on how to maximize cardiovascular health through exercise. A marriage of clinical cardiology and exercise physiology, this unique study improves assessment and prescription options for cardiologists, sports physicians, and other health professionals. Presenting the up-to-date work of 23 world-renowned experts, Exercise and the Heart in Health and Disease, Second Edition now contains new chapters and the latest findings on cardiovascular effects of exercise on women, emphasizing access to treatment the emerging issue of overtraining and the potential danger of hypertrophy of the myocardium in athletes the links between sudden cardiac death and exercise prescribing practices that focus on a more moderate active living approach exercise as a means of ameliorating vascular stress and hypertension tailoring exercise to different age groups and for high-risk patients with cardiovascular disorders the effects of exercise on conditions such as silent ischemia, angina, myocardial infarction, and congestive heart failure the role of exercise in rehabilitation from coronary bypass surgery, angioplasty, and cardiac transplantation and much more! Clarifies the various prescription options, matching type, frequency, duration, and intensity of exercise with the individualized needs of patients! Prodigiously referenced with almost 2000 literature citations-700 more than the previous edition-and featuring over 100 highly instructive tables, graphs, and drawings, Exercise and the Heart in Health and Disease, Second Edition is indispensable for cardiologists and cardiac rehabilitation specialists, nurses, physiotherapists, exercise physiologists, sports medicine physicians, internists, family practitioners, and medical school and graduate students in these disciplines.

Cardiovascular, respiratory, and related conditions cause more than 40 percent of all deaths globally, and their substantial burden is rising, particularly in low- and middle-income countries (LMICs). Their burden extends well beyond health effects to include significant economic and societal consequences. Most of these conditions are related, share risk factors, and have common control measures at the clinical, population, and policy levels. Lives can be extended and improved when these diseases are prevented, detected, and managed. This volume summarizes current knowledge and presents evidence-based interventions that are effective, cost-effective, and scalable in LMICs.