This volume is the second in "The Downstate Series of Research in Psychiatry." It is aseries devoted to the presentation of sig nificant research with relevance for both clinicians and researchers in the multiple subfields of psychiatry. This book focuses on the interactions between psychic phenomena and physical processes as studied by evoked brain potentials. It presents material concerned with physiological and psychological unifying processes, as weIl as research concerning technology and methods of obtaining meaningful measurements. As such it is representative of biological psychiatry at its best. Thus, it represents another step in new directions in psychiatric research but not an unanticipated direction. Scientific investigation into the human psyche took an unex pected turn when Sigmund Freud in the last part of the 19th Century turned his attention from neurological concerns to those of psychol ogy. His first attempts at explanations as noted in the "project," included a heavy emphasis on the biological substrate of behavior.

In neurophysiology, the emphasis has been on single-unit studies for a quarter century, since the sensory work by Lettwin and coworkers and by Hubel and Wiesel, the cen tral work by Mountcastle, the motor work by the late Evarts, and so on. In recent years, however, field potentials - and a more global approach general ly - have been receiving renewed and increasing attention. This is a result of new findings made possible by technical and conceptual advances and by the confirma tion and augmentation of earlier findings that were widely ignored for being contro versial or inexplicable. To survey the state of this active field, a conference was held in West Berlin in August 1985 that attempted to cover all of the new approaches to the study of brain function. The approaches and emphases were very varied: basic and applied, electric and magnetic, EEG and EP/ERP, connectionistic and field, global and local fields, surface and multielectrode, low frequencies and high frequencies, linear and non linear. The conference comprised sessions of invited lectures, a panel session of seven speakers on "How brains may work," and a concluding survey of relevant methodologies. The conference showed that the combination of concepts, methods, and results could open up new important vistas in brain research. Included here are the proceedings of the conference, updated and revised by the authors. Several attendees who did not present papers at the conference later ac cepted my invitation to write chapters for the book.

Brain dysfunction is a major clinical problem in intensive care, with potentially debilitating long-term consequences for post-ICU patients of any age. The resulting extended length of stay in the ICU and post-discharge cognitive dysfunction are now recognized as major healthcare burdens. This comprehensive clinical text provides intensivists and neurologists with a practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available. Initial sections review the epidemiology, outcomes, relevant behavioral neurology and biological mechanisms of brain dysfunction. Subsequent sections evaluate the available diagnostic options and preventative and therapeutic interventions, with a final section on clinical encephalopathy syndromes encountered in the ICU. Each chapter is rich in illustrations, with an executive summary and a helpful glossary of terms. Brain Disorders in Critical Illness is a seminal reference for all physicians and neuroscientists interested in the care and outcome of severely ill patients.

The Oxford Handbook of Event-Related Potential Components provides a detailed and comprehensive overview of the major ERP components. It covers components related to multiple research domains, including perception, cognition, emotion, neurological and psychiatric disorders, and lifespan development.

No other neurological condition allows the same opportunities for an intracranial electrophysiological study of the human brain as epilepsy does. Epileptic surgery is designed to remove the epileptic focus from the human brain, thereby effecting either cure or substantial reduction of seizures in an individual with an otherwise intractable condition. Its use as a treatment modality dates from the late 19th century, and it has become a widely used treatment option throughout the world in the last 20-30 years. The complexity of epilepsy cases in surgical centres, and the need for invasive electrode studies for pre-surgical evaluation, are both greatly increasing. Invasive Studies of the Human Epileptic Brain is the definitive reference text on the use of invasive electroencephalographic (EEG) diagnostic studies in human epilepsy. Written by some of the most renowned epilepsy experts of the 20th and 21st centuries, the authors provide their expertise and insights into the identification and mapping of intracranial epileptiform and non-epileptiform activity, mapping of the human brain function, and approaches in the use of invasive electroencephalography in a variety of clinical situations. The book is organized into an easily readable series of chapters and is brilliantly illustrated with case studies; each providing an intuitively comprehensive approach to invasive brain studies.

Methods, results, and evaluation of research in average evoked potentials.

While the brain is ruled to a large extent by chemical neurotransmitters, it is also a bioelectric organ. The collective study of Quantitative ElectroEncephaloGraphs (QEEG-the conversion of brainwaves to digital form to allow for comparison between neurologically normative and dysfunctional individuals), Event Related Potentials (ERPs - electrophysiological response to stimulus) and Neurotherapy (the process of actually retraining brain processes to) offers a window into brain physiology and function via computer and statistical analyses of traditional EEG patterns, suggesting innovative approaches to the improvement of attention, anxiety, mood and behavior.The volume provides detailed description of the various EEG rhythms and ERPs, the conventional analytic methods such as spectral analysis, and the emerging method utilizing QEEG and ERPs. This research is then related back to practice and all existing approaches in the field of Neurotherapy - conventional EEG-based neurofeedback, brain-computer interface, transcranial Direct Current Stimulation, and Transcranial Magnetic Stimulation - are covered in full. While it does not offer the breadth provided by an edited work, this volume does provide a level of depth and detail that a single author can deliver, as well as giving readers insight into the personl theories of one of the preeminent leaders in the field. - Provide a holistic picture of quantitative EEG and event related potentials as a unified scientific field - Present a unified description of the methods of quantitative EEG and event related potentials - Give a scientifically based overview of existing approaches in the field of neurotherapy - Provide practical information for the better understanding and treatment of disorders, such as ADHD, Schizophrenia, Addiction, OCD, Depression, and Alzheimer's Disease

This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The individual chapters cover several fascinating facets of contemporary neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Each of these topics require appropriate levels of analyses with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks, supplemented by models and theories to explain how different levels of brain dynamics interact with each other and how the failure of such interactions results in neurologic and mental disease. While such complex questions cannot be answered exhaustively by a dozen or so chapters, this volume offers a nice synthesis of current thinking and work-in-progress on micro-, meso- and macro- dynamics of the brain.

Event-Related Brain Potentials in Man contains the proceedings of a conference held on April 26-29, 1977, and sponsored by the National Institute of Mental Health in Rockville, Maryland to assess the field of event-related brain potential (ERP) research. The papers explore findings on ERPs in man in relation to the link between brain and behavior, brain functions, mental states, and drug interactions. Organized into eight chapters, this volume begins with an overview of the functional neuroanatomy and neurophysiology of ERPs, along with their measurement. It then proceeds with a discussion of some applications of ERPs to patients with neurological and sensory impairment, the use of ERPs to analyze sensation as well as perception and attention, the endogenous components of the ERP, the ERP correlates of psychopathology, and the event-related brain potentials across the life span. The reader is also introduced to ethical issues regarding ERPs, with reference to the history of encephalography. An epilogue assessing the increased status and maturity of the ERP field, along with uncharted territories and future prospects, concludes the book. This book will be of interest to scientists and clinical investigators working in biological sciences, neuropsychology, psychiatry, and neurology.