In the context of a plateau in the development of new methodologies for using nuclear magnetic resonance to investigate the structure of macromolecules, 21 lectures and ensuing discussions, and three panel discussions evaluate the status of the field and the directions it might take. The keynote address discusses the possibilities and limitations of NMR studies of the intramolecular dynamics of biomolecules. Among the other topics are proteins involved in cell adhesion processes, incorporating motional properties into the interpretation of three-dimensional solution structures, the accurate measurement of internuclear distances by suppressing spin diffusion, and flexible molecules. Abstracts are also provided for about 70 poster papers. Annotation copyright by Book News, Inc., Portland, OR

In the context of a plateau in the development of new methodologies for using nuclear magnetic resonance to investigate the structure of macromolecules, 21 lectures and ensuing discussions, and three panel discussions evaluate the status of the field and the directions it might take. The keynote address discusses the possibilities and limitations of NMR studies of the intramolecular dynamics of biomolecules. Among the other topics are proteins involved in cell adhesion processes, incorporating motional properties into the interpretation of three-dimensional solution structures, the accurate measurement of internuclear distances by suppressing spin diffusion, and flexible molecules. Abstracts are also provided for about 70 poster papers. Annotation copyright by Book News, Inc., Portland, OR

A useful and much-needed resource, this new book encapsulates the suicide literature into readable chunks, offering both practical skills and research based information. The book provides a comprehensive approach to many essential topics related to suicide and yet maintains a practical readability that busy clinicians will appreciate. Well organized chapters explain the relationship of suicide to specific topics, including a thorough discussion of at-risk clients and multiple aspects of working with suicidal clients (history, assessment, crises management, special populations, prevention, and postvention). Through use of this material, helping professionals will gain insights, practical skills, and therapeutic confidence into their work with the suicidal individual. Readers will appreciate the practical tips, lists, resources, and case studies available throughout. Features Include: Use of case examples and studies throughout. A full chapter on assessment provides solid practical information on a skill not often taught to pre-service helpers. Clinicians can find and use Internet and published resources throughout.

A practical and easy-to-use guide for healthcare professionals on the prevention, assessment and treatment of people at risk of suicide.

For anyone who has experienced the suicide of a loved one, coworker, neighbor, or acquaintance and is seeking information about coping with such a profound loss, this compassionate guide explores the unique responses inherent to their grief. Using the metaphor of the wilderness, the book introduces 10 touchstones to assist the survivor in this naturally complicated and particularly painful journey. The touchstones include opening to the presence of loss, embracing the uniqueness of grief, understanding the six needs of mourning, reaching out for help, and seeking reconciliation over resolution. Learning to identify and rely on each of these touchstones will bring about hope and healing.

Suicide is undoubtedly a worldwide major challenge for the public health. It is estimated that more than 150,000 persons in Europe die as a result of suicide every year and in several European countries suicide represents the principal cause of death among young people aged 14–25 years. It is true that suicide is a complex (and yet not fully understood) phenomenon and may be determined by the interaction between various factors, such as neurobiology, personal and familiar history, stressful events, sociocultural environment, etc. The suicide is always a plague for the population at risk and one of the most disgraceful events for a human being. Moreover, it implies a lot of pain often shared by the relatives and persons who are close to suicide subjects. Furthermore, it has been widely demonstrated that the loss of a subject due to suicide may be one of the most distressing events that may occur in mental health professionals resulting in several negative consequences, such as burnout, development of psychiatric symptoms and lower quality of life and work productivity. All considered, it is clear that the suicide prevention is a worldwide priority and every effort should be made in order to improve the early recognition of imminent suicide, manage suicidal subjects, and strengthen suicide prevention strategies. In our opinion, the first step of prevention is the improvement of knowledge in the field: this was the aim of this present special issue on Frontiers in Psychiatry. In this special issue, several papers have contributed to the suicide knowledge from several viewpoints and we hope that this will contribute to improve and disseminate knowledge on this topic.

Working in the Dark focuses on the authors’ understanding of an individual’s pre-suicide state of mind, based on their work with many suicidal individuals, with special attention to those who attempted suicide while in treatment. The book explores how to listen to a suicidal individual’s history, the nature of their primary relationships and their conscious and unconscious communications. Campbell and Hale address the searing emotional impact on relatives, friends and those involved with a person who tries to kill themself, by offering advice on the management of a suicide attempt and how to follow up in the aftermath. Establishing key concepts such as suicide fantasy and pre-suicidal states in adolescents, the book illustrates the pre-suicide state of mind through clinical vignettes, case studies, reflections from those in recovery and discussions with professionals. Working in the Dark will be of interest to social workers, probation officers, nurses, psychologists, counsellors, psychotherapists, psychoanalysts and doctors who work with those who have attempted suicide or are about to do so.

The past 25 years have seen a major paradigm shift in the field of violence prevention, from the assumption that violence is inevitable to the recognition that violence is preventable. Part of this shift has occurred in thinking about why violence occurs, and where intervention points might lie. In exploring the occurrence of violence, researchers have recognized the tendency for violent acts to cluster, to spread from place to place, and to mutate from one type to another. Furthermore, violent acts are often preceded or followed by other violent acts. In the field of public health, such a process has also been seen in the infectious disease model, in which an agent or vector initiates a specific biological pathway leading to symptoms of disease and infectivity. The agent transmits from individual to individual, and levels of the disease in the population above the baseline constitute an epidemic. Although violence does not have a readily observable biological agent as an initiator, it can follow similar epidemiological pathways. On April 30-May 1, 2012, the Institute of Medicine (IOM) Forum on Global Violence Prevention convened a workshop to explore the contagious nature of violence. Part of the Forum's mandate is to engage in multisectoral, multidirectional dialogue that explores crosscutting, evidence-based approaches to violence prevention, and the Forum has convened four workshops to this point exploring various elements of violence prevention. The workshops are designed to examine such approaches from multiple perspectives and at multiple levels of society. In particular, the workshop on the contagion of violence focused on exploring the epidemiology of the contagion, describing possible processes and mechanisms by which violence is transmitted, examining how contextual factors mitigate or exacerbate the issue. Contagion of Violence: Workshop Summary covers the major topics that arose during the 2-day workshop. It is organized by important elements of the infectious disease model so as to present the contagion of violence in a larger context and in a more compelling and comprehensive way.

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Alessandra Lemma - Winner of the Levy-Goldfarb Award for Child Psychoanalysis! Relating to Self-Harm and Suicide presents original studies and research from contemporary psychoanalysts, therapists and academics focusing on the psychoanalytic understanding of suicide and self-harm, and how this can be applied to clinical work and policy. This powerful critique of current thinking suggests that suicide and self-harm must be understood as having meaning within interpersonal and intrapsychic relationships, offering a new and more hopeful dimension for prevention and recovery. Divided into three sections, the book includes: a theoretical overview examples of psychoanalytic practice with self-harming and suicidal patients applications of psychoanalytic thinking to suicide and self-harm prevention. Relating to Self-Harm and Suicide will be helpful to psychoanalytic therapists, analysts and mental health professionals wanting to integrate psychoanalytic ideas into their work with self-harmers and the suicidal. This text will also be of use to academics and professionals involved in suicidal prevention.