This issue of Immunology and Allergy Clinics of North America, Guest Edited by Amy D. Klion, MD and Princess U. Ogbogu, MD, is devoted to Eosinophil-Associated Disorders. Drs. Klion and Ogbogu have assembled a group of expert authors to review the following topics: Evaluation and Differential Diagnosis of Persistent Marked Eosinophilia; Spectrum of Eosinophilic End Organ Manifestations; Eosinophilia in GI disorders; Eosinophilia in Hematologic Disorders; Eosinophilia in Rheumatologic/Vascular Disorders; Eosinophilia in Pulmonary Disorders; Eosinophilia in Infectious Diseases; Eosinophilia associated with Immune Deficiency and Immune Dysregulation; Eosinophilia in Dermatologic disorders; Management of Hypereosinophilic Syndromes; and Novel Therapies for Eosinophilic Disorders.

This issue of Immunology and Allergy Clinics of North America, Guest Edited by Amy D. Klion, MD and Princess U. Ogbogu, MD, is devoted to Eosinophil-Associated Disorders. Drs. Klion and Ogbogu have assembled a group of expert authors to review the following topics: Evaluation and Differential Diagnosis of Persistent Marked Eosinophilia; Spectrum of Eosinophilic End Organ Manifestations; Eosinophilia in GI disorders; Eosinophilia in Hematologic Disorders; Eosinophilia in Rheumatologic/Vascular Disorders; Eosinophilia in Pulmonary Disorders; Eosinophilia in Infectious Diseases; Eosinophilia associated with Immune Deficiency and Immune Dysregulation; Eosinophilia in Dermatologic disorders; Management of Hypereosinophilic Syndromes; and Novel Therapies for Eosinophilic Disorders.

In this issue of Immunology and Allergy Clinics, guest editors Drs. Glenn T. Furuta and Dan Atkins bring their considerable expertise to the topic of Eosinophilic Gastrointestinal Diseases. Top experts provide a multilayered examination of the current state of knowledge in the field, compiling an issue that serves as a convenient reference for the evaluation and management of eosinophilic esophagitis (EoE) and eosinophilic gastrointestinal diseases (EGIDs). - Contains 21 relevant, practice-oriented topics including epidemiological and clinical clues to the etiology of EoE; dietary management of EoE; quality of life with EoE; diversity, equity, and inclusion in EoE; clinical presentation of patients with EGIDs; pharmacologic management of EGIDs; and more. - Provides in-depth clinical reviews on eosinophilic gastrointestinal diseases, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Immunology and Allergy Clinics of North America, Guest Edited by Anne Marie Ditto, MD, is devoted to Anaphylaxis. Dr. Ditto has assembled a group of expert authors to review the following topics: Idiopathic Anaphylaxis; Mast Cell Activation Syndromes Presenting as Anaphylaxis; Anaphylaxis to Chemotherapy and Biologics; Fatal and Near Fatal Anaphylaxis; Anaphylaxis to Drugs; Perioperative Anaphylaxis; Exercise-Induced Anaphylaxis; Anaphylaxis to Carbohydrate Side Chains-alpha –gal; Anaphylaxis to Food; Anaphylaxis to Insect Stings; and Treatment and Prevention of Anaphylaxis.

This issue of Immunology and Allergy Clinics of North America, guest edited by Drs. Robert Wood, Pamela Guerrerio, and Corinne Keet, is devoted to Pediatric Allergy. Articles in this issue include: Role of the Environment in the Development of Allergic Disease; Genetics of Allergic Diseases; Optimizing the Diagnosis of Allergic Disorders; Anaphylaxis and Urticaria; Food Allergy: Epidemiology and Natural History; Inner City Asthma; Potential Treatments for Food Allergy; Eosinophilic Esophagitis; Atopic Dermatitis; Pediatric Asthma - Guidelines-based Care; Asthma - The Interplay Between Viral Infections and Allergic Diseases; Allergic Rhinitis; and Drug and Vaccine Allergy.

This issue of Immunology and Allergy Clinics of North America, guest edited by Dr. Jonathan A. Bernstein, is devoted to Rhinitis. Articles in this issue include: Rhinitis Subtypes, Endotypes, and Definitions; Allergic Rhinitis: Burden of Illness, Quality of Life and Control; Allergic Rhinitis: Mechanisms of Action; Allergic Rhinitis: Diagnosis; Allergic Rhinitis: Treatment; Non-allergic Rhinitis: Mechanism of Action; Non-allergic Rhinitis: Diagnosis; Non-allergic Rhinitis: Treatment; Localized Allergic Rhinitis; Occupational Rhinitis; Rhinitis in the Elderly; Complications of Rhinitis; Allergic Rhinitis: Environmental Determinants; Non-allergic Rhinitis: Environmental Determinants; and Novel, Alternative, and Controversial Therapies.

This issue of Immunology and Allergy Clinics of North America, Guest Edited by Anthony Montanaro, MD, is devoted to Primary Immunodeficiency Disorders. Dr. Montanaro has assembled a group of expert authors to review the following topics: Overview of Immunodeficiency Disorder; Severe Combined Immunodeficiency Disorder; Specific Antibody Deficiencies; Common Variable Immunodeficiency; Pulmonary Manifestations of Primary Immunodeficiency Disorders; Approach to the Child with Recurrent Infections; Immunoglobulin Treatment for Primary Immunodeficiency; Bone Marrow Transplantation for Primary Immunodeficiency; and Autoimmune Manifestations of Primary Immunodeficiency.

This issue of Immunology and Allergy Clinics, guest edited by Sandra Y. Lin, MD, will provide up-to-date clinical concepts regarding the diagnosis and management of the patient with Rhinosinusitis. Articles in this outstanding issue include: Current Concepts in the Management of Allergic Fungal Sinusitis; Aspirin Desensitization for Nasal Polyps in Aspirin-exacerbated respiratory disease (AERD); Primary Immunodeficiency and Rhinosinusitis; How to Measure Success in the Treatment of Patients with Chronic Rhinosinusitis; What is the Role of Macrolides and Doxycyline in Chronic Rhinosinusitis?; The Role of Biologics in the Treatment of Nasal Polyps; Personalized Medicine in Chronic Rhinosinusitis: Endotypes, Phenotypes, and Biomarkers; Management of Sinusitis in the Cystic Fibrosis Patient; The Microbiome and Chronic Rhinosinusitis; The Role of Allergic Rhinitis in Rhinosinusitis; The Role of Air Pollution in Chronic Rhinosinusitis; Odontogenic Sinusitis: Current Concepts in Diagnosis and Treatment; Olfactory Dysfunction and Chronic Rhinosinusitis; and The Impact of Allergen Immunotherapy on Chronic Rhinosinusitis.

In this issue of Immunology and Allergy Clinics, guest editor Dr. Flavia Hoyte brings her considerable expertise to the topic of Biologics in Allergic/Immunologic Conditions. Top experts provide an overview of the state of biologic treatments for autoimmune and allergic conditions including asthma, COPD, food allergies, atopic dermatitis; and more. - Contains 13 relevant, practice-oriented topics including current and emerging biologics in CSU; biologics in AERD and ABPA; and multiple articles on biologics in asthma, including the role of biomarkers, the potential to achieve clinical remission, real-world studies, emerging biologics; and more. - Provides in-depth clinical reviews on biologics in allergic/immunologic conditions, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.