This book is the principal account of epidemiology’s role in the development of effective measures to identify, prevent, and treat diseases. Throughout history, epidemiologists have challenged conventional knowledge, elucidating mysteries of causality and paving the way for remedies. From the outbreak of the bubonic plague, cholera, and cancer to the search for an effective treatment of AIDS and the origins of Alzheimer’s disease, epidemiological thought has been crucial in shaping our understanding of population health issues. Alfredo Morabia’s lucid retelling sheds new light on the historical triumphs of epidemiological research and allows for contemporary readers, patients, and nontechnical audiences to make sense of the immense amount of health information disseminated by the media. By drawing from both historical and contemporary sources, Morabia provides the reader with the tools to differentiate health beliefs from health knowledge. The book covers important topics, including the H1N1 swine flu epidemic, breast cancer, the effects of aspirin, and the link between cigarettes and lung cancer. Enigmas of Health and Disease is a concise narrative helping patients and health providers develop a more informed relationship.

When the cattle-borne sickness known as Mad Cow Disease first appeared in America in 2003, authorities were quick to assure the nation that the outbreak was isolated, quarantined, and posed absolutely no danger to the general public. What we were not told was that the origins of the sickness may already have been here and suspected for a quarter of a century. This illuminating exposé of the threat to our nation's health reveals for the first time how Mad Cow Disease (a.k.a. Bovine Spongiform Encephalopathy) has jumped species, infecting humans in the form of Creutzfeldt-Jakob Disease (CJD), and may be hidden in the enormous increase in the number of Alzheimer's cases since 1979. Detailing the history and biology of Mad Cow Disease, Brain Trust discloses how an investigation into the mysterious deaths in a group of cannibals in a remote part of the world evolved into a research program in the United States that may have had unforeseen and frightening consequences. The shocking questions examined include: • Have millions of Americans already been exposed to the prions known to cause Mad Cow Disease through years of eating tainted beef? • Does the epidemic of prion disease spreading like wildfire through the nation's deer and elk pose a threat to hunters and venison eaters? • Are the cattle mutilations discovered in the last 30 years part of a covert, illegal sampling program designed to learn how far the deadly prions have spread throughout the nation's livestock and beef products? Exposing the devastating truth about Mad Cow Disease and a new theory of the possible consequences of a little-known government research program and the potential national health catastrophe that may be the result, Brain Trust inoculates Americans with an effective cure: the truth.

Shows how the investigation of local outbreaks of typhoid fever in Victorian Britain led to the emergence of the modern discipline of epidemiology as the leading science of public health

This book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented. Many aspects of ceramide and sphingolipid biology are addressed in this book. Its focus is the metabolism of ceramide in normal and diseased states and the biophysical and biochemical mechanisms governing the bioactivity of these molecules. Sphingolipid research has surged over the past thirty years and this book gathers the recent findings of various aspects of sphingolipid biochemistry. World-renowned scientists from the field of lipid biology, specifically sphingolipid biochemistry, were gathered to write this book. Scholars from most continents of the globe committed to write diligently about their expertise and the newest findings in the relevant fields. This book came to fruition after almost a year and a half of laborious preparation and diligent writings. This book is targeted to the experienced reader who is looking to read about the various aspects of bioactive ceramide signaling, as well as to the newcomer into the field, as the topics are explained in concise yet very informative manner. The authors and editor wish all readers a pleasant time reading this volume, and are adamant that this book will meet all expectations.

Have neighborhoods been left out of the seismic healthcare reform efforts to connect struggling Americans with the help they need? Even as US spending on healthcare skyrockets, impoverished Americans continue to fall ill and die of preventable conditions. Although the majority of health outcomes are shaped by non-medical factors, public and private healthcare reform efforts have largely ignored the complex local circumstances that make it difficult for struggling men, women, and children to live healthier lives. In Dying and Living in the Neighborhood, Dr. Prabhjot Singh argues that we must look beyond the walls of the hospital and into the neighborhoods where patients live and die to address the troubling rise in chronic disease. Building on his training as a physician in Harlem, Dr. Singh draws from research in sociology and economics to look at how our healthcare systems are designed and how the development of technologies like the Internet enable us to rethink strategies for assembling healthier neighborhoods. In part I, Singh presents the story of Ray, a patient whose death illuminated how he had lived, his neighborhood context, and the forces that accelerated his decline. In part II, Singh introduces nationally recognized pioneers who are acting on the local level to build critical components of a neighborhood-based health system. In the process, he encounters a movement of people and organizations with similar visions of a porous, neighborhood-embedded healthcare system. Finally, in part III he explores how civic technologies may help forge a new set of relationships among healthcare, public health, and community development. Every rising public health leader, frontline clinician, and policymaker in the country should read this book to better understand how they can contribute to a more integrated and supportive healthcare system.

A NEW YORK TIMES BESTSELLER The official book behind the Academy Award-winning film The Imitation Game, starring Benedict Cumberbatch and Keira Knightley It is only a slight exaggeration to say that the British mathematician Alan Turing (1912–1954) saved the Allies from the Nazis, invented the computer and artificial intelligence, and anticipated gay liberation by decades—all before his suicide at age forty-one. This New York Times bestselling biography of the founder of computer science, with a new preface by the author that addresses Turing’s royal pardon in 2013, is the definitive account of an extraordinary mind and life. Capturing both the inner and outer drama of Turing’s life, Andrew Hodges tells how Turing’s revolutionary idea of 1936—the concept of a universal machine—laid the foundation for the modern computer and how Turing brought the idea to practical realization in 1945 with his electronic design. The book also tells how this work was directly related to Turing’s leading role in breaking the German Enigma ciphers during World War II, a scientific triumph that was critical to Allied victory in the Atlantic. At the same time, this is the tragic account of a man who, despite his wartime service, was eventually arrested, stripped of his security clearance, and forced to undergo a humiliating treatment program—all for trying to live honestly in a society that defined homosexuality as a crime. The inspiration for a major motion picture starring Benedict Cumberbatch and Keira Knightley, Alan Turing: The Enigma is a gripping story of mathematics, computers, cryptography, and homosexual persecution.

A collection of more than fifty hard-to-crack medical quandaries, featuring the best of The New York Times Magazine's popular Diagnosis column—now a Netflix original series “Lisa Sanders is a paragon of the modern medical detective storyteller.”—Atul Gawande, author of Being Mortal As a Yale School of Medicine physician, the New York Times bestselling author of Every Patient Tells a Story, and an inspiration and adviser for the hit Fox TV drama House, M.D., Lisa Sanders has seen it all. And yet she is often confounded by the cases she describes in her column: unexpected collections of symptoms that she and other physicians struggle to diagnose. A twenty-eight-year-old man, vacationing in the Bahamas for his birthday, tries some barracuda for dinner. Hours later, he collapses on the dance floor with crippling stomach pains. A middle-aged woman returns to her doctor, after visiting two days earlier with a mild rash on the back of her hands. Now the rash has turned purple and has spread across her entire body in whiplike streaks. A young elephant trainer in a traveling circus, once head-butted by a rogue zebra, is suddenly beset with splitting headaches, as if someone were “slamming a door inside his head.” In each of these cases, the path to diagnosis—and treatment—is winding, sometimes frustratingly unclear. Dr. Sanders shows how making the right diagnosis requires expertise, painstaking procedure, and sometimes a little luck. Intricate, gripping, and full of twists and turns, Diagnosis puts readers in the doctor’s place. It lets them see what doctors see, feel the uncertainty they feel—and experience the thrill when the puzzle is finally solved.

In spite of all the papers that others have written about the manuscript, there is no complete survey of all the approaches, ideas, background information and analytic studies that have accumulated over the nearly fifty-five years since the manuscript was discovered by Wilfrid M. Voynich in 1912. This report pulls together all the information the author could obtain from all the sources she has examined, and to present it in an orderly fashion. The resulting survey will provide a firm basis upon which other students may build their work, whether they seek to decipher the text or simply to learn more about the problem.

Cancer is a transnational condition involving the unprecedented flow of health information, technologies, and people across national borders. Such movement raises questions about the nature of therapeutic citizenship, how and where structurally vulnerable populations obtain care, and the political geography of blame associated with this disease. This volume brings together cutting-edge anthropological research carried out across North and South America, Europe, Africa and Asia, representing low-, middle- and high-resource countries with a diversity of national health care systems. Contributors ethnographically map the varied nature of cancer experiences and articulate the multiplicity of meanings that survivorship, risk, charity and care entail. They explore institutional frameworks shaping local responses to cancer and underlying political forces and structural variables. Chapter 3 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781138776937_oachapter3.pdf

This book examines the history of the Victorian Cancer Registry (VCR) in Australia from its establishment in the late 1930s through to the present day. It sheds new light on the history of medicine and the broader social and cultural histories affected by advances in cancer control science, providing a historical account of cancer registration that is empirically grounded in new archival and oral sources. It addresses the obstacles that proponents of cancer registration faced, how governments came to support permanent registries, and the subsequent contributions of the VCR and other registries to cancer research. In charting this history, the book discusses some of the political, social, and cultural implications of registry-driven science, and the links between developments in scientific knowledge and campaigning for policy changes around cancer.