Today a number of gastrointestinal disorders that once required open surgical or percutaneous management are being managed with endolumenal therapies. This has led to an evolution of minimally invasive endolumenal approaches to many disorders. This issue reviews the progress made in the application of endolumenal therapies and not only discuss current applications but future efforts and directions for clinical investigation. Articles will focus on the scope of the problem, past management options, new endolumenal options, investigations with endolumenal therapy, current status (clinical trial results if available), and future directions.

Dr. Allen’s issue focuses on how gastroenterologists can maximize the “value of colonoscopy – where value is defined as quality/cost. Clinical issues are covered, like sedation issues, complications of colonoscopy, and infection risk, but the majority of the articles deal with the discussions that surround quality colonoscopy—articles like: Risk Management and Legal Issues for Colonoscopy; Cost effectiveness of Colonoscopy in Prevention of Colon Cancer; Efficacy and Effectiveness of Colonoscopy: How Do We Bridge the Gap?; Current State of Colonoscopy Performance Measures; Use of Databases and Registries to Enhance Quality; and Maximizing the Value of Colonoscopy in Community, to name a few. In preparation of the changing landscape of healthcare, this issue will be an important one for all practicing gastroenterologists.

In collaboration with Consulting Editor, Dr. Charles J. Lightdale, Guest Editor Dr. Sachin Wani has put together a state-of-the art issue that presents the latest advances in Barrett's Esophagus. He has secured expert authors who have contributed clinical reviews on the following topics: The epidemiology of Barrett's esophagus and esophageal adenocarcinoma – implications for screening and surveillance; Endoscopic screening for Barrett's esophagus and esophageal adenocarcinoma: rationale, candidates and challenges; Progress in screening for Barrett's esophagus: beyond standard upper endoscopy; Best practices in surveillance for Barrett's esophagus; Pathologic assessment of Barrett's esophagus and Barrett's related neoplasia: Do we need quality indicators; Cost effectiveness of screening, surveillance and endoscopic eradication therapies in Barrett's esophagus and early esophageal cancer; Advanced imaging and sampling in Barrett's esophagus: Artificial intelligence to the rescue; Advances in biomarkers for risk stratification in Barrett's esophagus; Current status of chemoprevention in Barrett's esophagus; Optimizing outcomes with radiofrequency frequency ablation of Barrett's esophagus: candidates, efficacy and durability; Updates in cryotherapy for Barrett's esophagus; Role of endoscopic mucosal resection and endoscopic submucosal dissection in the management of Barrett's related neoplasia; Practical approach to refractory and recurrent Barrett's esophagus; Surgical management of Barrett's related neoplasia; and Measuring Quality in Barrett's esophagus: Time to embrace quality indicators. Endoscopists will come away with the information they need to screen, diagnose, and treat patients with Barrett's Esophagus.

In consultation with Dr. Charles Lightdale, Dr. Cai has assembled a list of articles devoted to gastroparesis with the most current and clinically relevant content. Dr. Cai invited top experts from well-known institutions to contribute reviews on the following topics: Epidemiology and Pathophysiology of Gastroparesis; Diabetic Gastroparesis and Non-Diabetic Gastroparesis; Clinical Manifestations and Natural History of Patients with Gastroparesis; Evaluation of Patients with Suspected Gastroparesis; Symptomatic Management of Gastroparesis; Gastric Electrical Stimulator for Treatment of Gastroparesis; Surgical Treatment for Gastroparesis; Botulinum Toxin Injection for Treatment of Gastroparesis; Stent Placement for Treatment for Gastroparesis; Technical Aspects of Per Oral Endoscopic Pyloromyotomy; Gastric Emptying Scintigraphy for Evaluation of Patients with Gastroparesis before Per Oral Endoscopic Myotomy; Outcomes of Per Oral Endoscopic Pyrolomyotomy in France; Outcomes of Per Oral Endoscopic Pyloromyotomy in China; and Outcomes of Per Oral Endoscopic Pyloromyotomy in the United States. Readers will come away with the most current clinical information they need to inform clinical decisions to improve patient outcomes.

In collaboration with Consulting Editor, Dr. Charles Lightdale, Dr. Douglas K. Rex has put together a state-of the-art issue of the Gastrointestinal Endoscopy Clinics of North America devoted to Colonoscopic Polypectomy. Expert authors have contributed clinical reviews that address best practices, evidentiary support, and expert recommendations. Articles specifically address the following topics: Endoscopic assessment prior to resection: What the experts do; Reviewing the evidence that polypectomy prevents cancer; The cold revolution: how far can it go?; Best methods for resection of diminutive and small polyps; Teaching polypectomy and assessing the quality of polypectomy; How to perform wide-field EMR and follow-up examinations; Surgery vs. EMR vs. ESD for large polyps: Making sense of when to use which approach; How to learn and perform ESD and full thickness endoscopic resection in the colorectum in the U.S; Underwater endoscopic mucosal resection (EMR); Lesion retrieval, lesions handling, marking; and Closure of defects and management of complications. Readers will come away with the latest information they need to evaluate options for lesion resection and to improve outcomes.

In this issue of Gastrointestinal Endoscopy Clinics of North America, guest editors Drs. Kenneth J. Chang and Jason B. Samarasena bring their considerable expertise to the topic of The Endoscopic Oncologist. The practice of gastrointestinal endoscopy intersects with oncology in many ways, much of it involving pre-cancerous conditions. But the endoscopist's role in diagnosing, staging, and treating cancer patients is expanding. This issue is devoted to the current and future role of the endoscopic oncologist, with topics such as endoscopic diagnosis of luminal gastrointestinal cancer and extra-luminal cancer; endoscopic resection for early cancer; and more. - Contains 12 relevant, practice-oriented topics including endoscopic ultrasound cancer staging; management of biliary obstruction; endoscopic management of colonic obstruction; endoscopic treatment of tumor bleeding; endoscopic ultrasound-guided pain management; and more. - Provides in-depth clinical reviews on the endoscopic oncologist, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

The topics covered in this issue, an update from what was first published in the Gastrointestinal Endoscopy Clinics in 2008, reflect the fact that NOTES is seeing a resurgence in popularity. Now, eight years later, there is more data to confirm safety, to look at the best options for using natural orifices, and to talk about optimal training scenarios. The Guest Editor has enlisted some of the top experts on NOTES to contribute articles devoted to Seminal Developments: SM Tunnel Technique; Peroral Endoscopic Myotomoy (POEM); Submucosal Tumor Endoscopic Resection; Endoscopic Full Thickness Resection; Submucosal Tunneling for NOTES Procedures Beyond Resection; Pyloromyotomy; New NOTES: Western Perspective; and Why Did the Old NOTES Fail: Lessons Learned that can Guide New NOTES Development.

Together with Consulting Editor Dr. Charles Lightdale, Dr. Qiang Cai has put together a comprehensive issue devoted to gastroparesis. Expert authors have contributed clinical review articles on the following topics: Epidemiology and Pathophysiology of Gastroparesis; Non-Diabetic Gastroparesis; Clinical Manifestations and Natural History of Patients with Gastroparesis; Evaluation of Patients with Suspected Gastroparesis; Symptomatic Management of Gastroparesis; Gastric Electrical Stimulator for treatment of Gastroparesis; Surgical Treatment for Gastroparesis; Botulinum Toxin Injection for Treatment of Gastroparesis; Stent Placement for Treatment for Gastroparesis; Technical Aspects of Per Oral Endoscopic Pyloromyotomy; Gastric Emptying Scintigraphy for Evaluation of Patients with Gastroparesis before Per Oral Endoscopic Myotomy; Outcomes of Per Oral Endoscopic Pyrolomyotomy in France; Outcomes of Per Oral Endoscopic Pyloromyotomy in China; Outcomes of Per Oral Endoscopic Pyloromyotomy in the United States.. Readers will come away with the information they need to improve endoscopic techniques and improve patient outcomes.

In consultation with Consulting Editor, Dr. Charles Lightdale, Dr. Kenneth Chang has assembled top authors to provide a current update on the management of GERD. Clinical review articles provide updates on the these important topics: Mechanism and Pathophysiology of GERD; Personalized Approach in the work-up and management of GERD; Proton Pump Inhibitors; Radiofrequency Treatment for GERD; Trans-oral Incisionless Fundoplication (TIF); Innovations in Endoscopic Therapy for GERD; Laparoscopic Hernia Repair and Fundoplication, Failed Nissen; Laparoscopic Sphincter Augmentation (LINX); Refractory GERD and Functional Heartburn; and Extra-esophageal GERD and LPR. Readers will come away with the latest techniques and clinical applications to improve patient outcomes.

In this issue of Gastrointestinal Endoscopy Clinics of North America, we invited pioneers and experts in this field to share recent advancements and expansions of ESD and its technical aspects in different organ systems. In addition, this issue covers the associated techniques of per oral endoscopic myotomy (POEM) and natural orifice transluminal endoscopic surgery (NOTES) to further advance understanding of the latest breakthroughs in endoscopic therapy. Current trends surrounding ESD around the world—in Asia, Europe, and the United States—are addressed as well. Some articles include videos for readers to watch ESD procedures in action, performed by experts, for easier understanding of ESD techniques. The Guest Editors expect that this issue will inspire more physicians to explore the expanding possibilities of endoscopic therapy such as ESD and POEM and to advocate minimally invasive treatment for patients.