Endocrine Disruption Modeling
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Author |
: |
Publisher |
: Academic Press |
Total Pages |
: 299 |
Release |
: 2004-08-11 |
ISBN-10 |
: 9780080522883 |
ISBN-13 |
: 0080522882 |
Rating |
: 4/5 (83 Downloads) |
Synopsis Nuclear Receptor Coregulators by :
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.*First published in 1943, Vitamins and Hormones is AP's longest running serial*Each volume contains cutting edge reviews by leading contributors
Author |
: National Research Council |
Publisher |
: National Academies Press |
Total Pages |
: 453 |
Release |
: 2000-02-03 |
ISBN-10 |
: 9780309064194 |
ISBN-13 |
: 0309064198 |
Rating |
: 4/5 (94 Downloads) |
Synopsis Hormonally Active Agents in the Environment by : National Research Council
Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.
Author |
: James Devillers |
Publisher |
: CRC Press |
Total Pages |
: 420 |
Release |
: 2009-04-27 |
ISBN-10 |
: 9781420076363 |
ISBN-13 |
: 1420076361 |
Rating |
: 4/5 (63 Downloads) |
Synopsis Endocrine Disruption Modeling by : James Devillers
Uses Computational Tools to Simulate Endocrine Disruption PhenomenaEndocrine Disruption Modeling provides a practical overview of the current approaches for modeling endocrine activity and the related potential adverse effects they may induce on environmental and human health. Based on the extensive research of an international panel of contributor
Author |
: Rosario Pivonello |
Publisher |
: Springer Nature |
Total Pages |
: 532 |
Release |
: 2023-04-20 |
ISBN-10 |
: 9783030390440 |
ISBN-13 |
: 3030390446 |
Rating |
: 4/5 (40 Downloads) |
Synopsis Environmental Endocrinology and Endocrine Disruptors by : Rosario Pivonello
This book describes how exposure to various classes of endocrine disruptors, as well as other environmental chemicals targeting the endocrine system by alternative non-endocrine mechanisms, impact on endocrinological and endocrinological-related diseases. It includes comprehensive reviews of all aspects of environmental endocrinology, ranging from sources and patterns of exposure and identification of endocrine targets to direct endocrine disruptive mechanisms and indirect actions on the endocrine system, the latter including endocrine cell-directed cytotoxicity, oxidative damage, and genetic and epigenetic aberrations resulting in endocrine damage. It also examines the causal pathways and offers an extensive overview of downstream endocrinological and endocrinological-related disorders. In addition, several chapters focus on transgenerational actions, which are a topic of particular interest. Lastly, evidence from preclinical and clinical studies provides the basis for an in-depth, critical discussion of each topic. The book is part of the SpringerReference program, which provides access to ‘living editions’ that are constantly updated using a dynamic peer-review publishing process.
Author |
: Evanthia Diamanti-Kandarakis |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 383 |
Release |
: 2011-12-01 |
ISBN-10 |
: 9781607615613 |
ISBN-13 |
: 1607615614 |
Rating |
: 4/5 (13 Downloads) |
Synopsis Endocrine Disruptors and Puberty by : Evanthia Diamanti-Kandarakis
Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole. Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge. In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors. Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem. An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions.
Author |
: Kunal Roy |
Publisher |
: Springer |
Total Pages |
: 129 |
Release |
: 2015-04-11 |
ISBN-10 |
: 9783319172811 |
ISBN-13 |
: 3319172816 |
Rating |
: 4/5 (11 Downloads) |
Synopsis A Primer on QSAR/QSPR Modeling by : Kunal Roy
This brief goes back to basics and describes the Quantitative structure-activity/property relationships (QSARs/QSPRs) that represent predictive models derived from the application of statistical tools correlating biological activity (including therapeutic and toxic) and properties of chemicals (drugs/toxicants/environmental pollutants) with descriptors representative of molecular structure and/or properties. It explains how the sub-discipline of Cheminformatics is used for many applications such as risk assessment, toxicity prediction, property prediction and regulatory decisions apart from drug discovery and lead optimization. The authors also present, in basic terms, how QSARs and related chemometric tools are extensively involved in medicinal chemistry, environmental chemistry and agricultural chemistry for ranking of potential compounds and prioritizing experiments. At present, there is no standard or introductory publication available that introduces this important topic to students of chemistry and pharmacy. With this in mind, the authors have carefully compiled this brief in order to provide a thorough and painless introduction to the fundamental concepts of QSAR/QSPR modelling. The brief is aimed at novice readers.
Author |
: Philippa D. Darbre |
Publisher |
: Academic Press |
Total Pages |
: 390 |
Release |
: 2015-03-21 |
ISBN-10 |
: 9780128011201 |
ISBN-13 |
: 0128011203 |
Rating |
: 4/5 (01 Downloads) |
Synopsis Endocrine Disruption and Human Health by : Philippa D. Darbre
Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations
Author |
: Muhammad Sajid Hamid Akash |
Publisher |
: Springer |
Total Pages |
: 0 |
Release |
: 2021-08-06 |
ISBN-10 |
: 303045925X |
ISBN-13 |
: 9783030459253 |
Rating |
: 4/5 (5X Downloads) |
Synopsis Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies by : Muhammad Sajid Hamid Akash
This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.
Author |
: Leonardo Trasande |
Publisher |
: Harvest Publications |
Total Pages |
: 245 |
Release |
: 2019 |
ISBN-10 |
: 9781328553492 |
ISBN-13 |
: 1328553493 |
Rating |
: 4/5 (92 Downloads) |
Synopsis Sicker, Fatter, Poorer by : Leonardo Trasande
A leading voice in public health policy and top environmental medicine scientist reveals the alarming truth about how hormone-disrupting chemicals are affecting our daily lives--and what we can do to protect ourselves and fight back. Lurking in our homes, hiding in our offices, and polluting the air we breathe is something sinister. Something we've turned a blind eye to for far too long. Dr. Leonardo Trasande, a pediatrician, professor, and world-renowned researcher, tells the story of how our everyday surroundings are making us sicker, fatter, and poorer. Dr. Trasande exposes the chemicals that disrupt our hormonal systems and damage our health in irreparable ways. He shows us where these chemicals hide--in our homes, our schools, at work, in our food, and countless other places we can't control--as well as the workings of policy that protects the continued use of these chemicals in our lives. Drawing on extensive research and expertise, he outlines dramatic studies and emerging evidence about the rapid increases in neurodevelopmental, metabolic, reproductive, and immunological diseases directly related to the hundreds of thousands of chemicals that we are exposed to every day. Unfortunately, nowhere is safe. But, thanks to Dr. Trasande's work on the topic, and his commitment to effecting change, this book can help. Through a blend of narrative, scientific detective work, and concrete information about the connections between chemicals and disease, he shows us what we can do to protect ourselves and our families in the short-term, and how we can help bring the change we deserve.
Author |
: Andrea C. Gore |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 361 |
Release |
: 2007-06-08 |
ISBN-10 |
: 9781597451079 |
ISBN-13 |
: 159745107X |
Rating |
: 4/5 (79 Downloads) |
Synopsis Endocrine-Disrupting Chemicals by : Andrea C. Gore
This book provides comprehensive coverage of the three most important themes in the field of Endocrine Disrupting Chemicals (EDC) research: the basic biology of EDCs, particularly their effects on reproductive systems; EDC effects on humans and wildlife, including biomedical considerations; and potential interventions and practical advice for dealing with the problem of EDCs.