Emerging Nanotechnologies in Immunology aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanophamaceuticals currently in the pipeline of S&T development for skin, ocular, and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure.The scientific development of manufactured nanomaterials for drug delivery is increasing rapidly. One of the most prominent applications is topical drug delivery, where cutaneous, ocular, and nasal exposure becomes even more relevant. These targets are the first barrier that nanoparticles encounter when in contact with the human body.The contributors addresses a representative set of the broad spectrum of nanopharmaceuticals currently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue engineered skin substitutes. Regulation and risk is also covered, since the safety of these nanophamaceuticals still represents a barrier to their wide innovative use. - Provides the reader with a thorough knowledge of the safety aspects of nanopharmaceuticals which are currently under research - Focuses on the characterization and quantification of the nanopharmaceuticals - Allows readers to understand the correlation between the nature of the materials and their potential nanotoxicological effects - Includes an overview of regulatory aspects related to the R&D of nanopharmaceuticals

Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices covers the modern micro and nanotechnologies used for diagnosis, drug delivery, and theranostics using micro, nano, and implantable systems. In-depth coverage of all aspects of disease treatment is included. In addition, the book covers cutting-edge research and technology that will help readers gain knowledge of novel approaches and their applications to improve drug/agent specificity for diagnosis and efficient disease treatment. It is a comprehensive guide for medical specialists, the pharmaceutical-industry, and academic researchers discussing the impact of nanotechnology on diagnosis, drug delivery, and theranostics. - Gives readers working in immunology, drug delivery, and medicine a greater awareness on how novel nanotechnology orientated methods can help improve treatment - Provides readers with backgrounds in nanotechnology, chemistry, and materials science an understanding on how nanotechnology is used in immunology and drug delivery - Includes focused coverage of the use of nanodevices in diagnostics, therapeutics, and theranostics not offered by other books

Recently, immunomodulatory nanomaterials have gained immense attention due to their involvement in the modulation of the body’s immune response to cancer therapy. This book highlights various immunomodulatory nanomaterials (including organic, polymer, inorganic, liposomes, viral, and protein nanoparticles) and their role in cancer therapy. Additionally, the mechanism of immunomodulation is reviewed in detail. Finally, the challenges of these therapies and their future outlook are discussed. We believe this book will be helpful to a broad community including students, researchers, educators, and industrialists.

Emerging Nanotechnologies for Medical Applications focuses on both commercial and premarket tools and their applications in medicine. The book develops the concept of integrating different technologies along a hierarchical structure of biological systems and clarifies biomechanical interactions on different levels for the analysis of multiscale pathophysiological phenomena. With a focus on nano-scale processes and biomedical applications, it demonstrates how knowledge can be utilized in a range of areas, including the diagnosis and treatment of various human diseases, and in alternative energy production. This book is an important reference source for scientists and researchers involved in micro- and nano-engineering, bio-nanotechnology, biomedical engineering, nanomedicine, and industries involved with optical devices, computer simulation and pharmaceuticals. - Shows how nanotechnology is being used to improve outcomes in areas of cancer, tissue grafting, and printing drugs - Explores a variety of nanoengineering techniques used for biomedical applications, including for cardiovascular, renal and dental treatments - Assesses the major challenges of manufacturing nanomaterials-based medicines on an industrial scale

This book comprehensively reviews the history of nanotechnology, and describes the physiochemical properties of various nanoparticles and their biomedical applications. Covering the biotoxicity of nanoparticles, their bio-distribution and release kinetics, and their role in diagnosis, pre-clinical drug discovery and disease prevention, it also examines the application of nanoscaffolds in tissue engineering and as cell culture templates. Further, the book discusses several fabrication methodologies for regenerative medicine, and explores nanotechnology-based stem cell therapeutics, including stem cell transfection, stem cell delivery, and stem cell expansion for promoting tissue regeneration. Lastly, it addresses the use of DNA barcoding technology from nanosamples for the detection, identification and validation of emerging pathogens, biodiversity and ancient remnants of living specimens, and highlights various strategies for the plant-mediated synthesis of nanoparticles. Given its scope, it is a valuable reference resource for graduate students and researchers interested in understanding the diverse range of biomedical applications of nanoparticles.

This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles. - Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development - Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development - Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines

Nanoparticles and the Immune System provides a reference text for toxicologists, materials scientists and regulators and covers the key issues of interaction of nanomaterials with the immune system. The book discusses several issues that toxicologists and regulators need to know: identification of endpoints that are relevant for assessing hazard, evaluating impact on immunologically frail populations, and how to evaluate chronic/cumulative effects. In addition, the book addresses the possibility of turning the immunomodulating properties of certain nanomaterials to our advantage for amplifying immune responses in certain diseases or preventive strategies (e.g. vaccination). - Identifies endpoints relevant for assessing hazardous situations, evaluating the impact on immunologically frail populations and how to gauge chronic/cumulative effects - Raises the awareness of the importance of knowing the effects of the new nanomaterials on our immune system

This unique book provides comprehensive overview of the field of immunology related to engineered nanomaterials used for biomedical applications. It contains literature review, case studies and protocols. The book can serve as a source of information about nanoimmunotoxicology for both junior scientists and experts in the field. The authors have more than 10 years of experience with preclinical characterization of engineered nanomaterials used for medical applications, and they share their experience with the readers. In addition, the international team of experts in the field provides the opinion and share the expertise on individual topics related to nanoparticle physicochemical characterization, hematocompatibility, and effects on the immune cell function . The second edition contains updated chapters from the first edition plus new chapters covering areas of tumor immunology, nanoparticle interaction with lymphatic system, mathematical modeling of protein corona, utilization of nanoparticles for the delivery of antiviral drugs, extensive analysis of nanoparticle anti-inflammatory and immunosuppressive properties, novel ways of protecting therapeutic nanoparticles from the immune recognition, as well as case studies regarding nanoparticle sterilization, complement activation, protein binding and immunotherapy of cancer. The second edition comes in 3 volumes. Volume 1 is focused on nanoparticle characterization, sterility and sterilization, pyrogen contamination and depyrigenation. It also contains overview of regulatory guidelines, protocols for in vitro and in vivo immunotoxicity studies, and correlation between in vitro and in vivo immunoassays. Volume 2 is focused on hematocompatibility of nanomaterials. It provides comprehensive review and protocols for investigating nanoparticle interaction with erythrocytes, platelets, endothelial cells, plasma coagulation factors and plasma proteins forming so called 'corona' around nanoparticles. Volume 3 is dedicated to nanoparticle interaction with and effects on the immune cell function. It also contains examples of nanoparticle use for delivery of antiviral and anti-inflammatory drugs.

Emerging Nanotechnologies in Rechargeable Energy Storage Systems addresses the technical state-of-the-art of nanotechnology for rechargeable energy storage systems. Materials characterization and device-modeling aspects are covered in detail, with additional sections devoted to the application of nanotechnology in batteries for electrical vehicles. In the later part of the book, safety and regulatory issues are thoroughly discussed. Users will find a valuable source of information on the latest developments in nanotechnology in rechargeable energy storage systems. This book will be of great use to researchers and graduate students in the fields of nanotechnology, electrical energy storage, and those interested in materials and electrochemical cell development. - Gives readers working in the rechargeable energy storage sector a greater awareness on how novel nanotechnology oriented methods can help them develop higher-performance batteries and supercapacitor systems - Provides focused coverage of the development, process, characterization techniques, modeling, safety and applications of nanomaterials for rechargeable energy storage systems - Presents readers with an informed choice in materials selection for rechargeable energy storage devices

Exploring an Emerging Technique of Nanotechnology in Vaccine Design and Manufacturing to combat SARS-CoV-2. Nanoparticles are loosely defined as nanoscale-sized and tunable particulate structures that mimic structural features of natural viruses. Besides traditional vaccine modalities and DNA and vector-based vaccines, nanoparticle vaccines offer a unique opportunity to advance vaccine science and provide tractable solutions to the current pandemic and beyond. This adaptive design makes them highly promising platforms for next-generation vaccine development, providing pathways to drive strong nAb responses, or broader antibody-based immunity that might better account for variation and evolution of viral pathogens. COVID-19 has become a major cause of global mortality and driven massive health and economic disruptions. At present, over 26 nanoparticle vaccine candidates have advanced into clinical testing, with ∼60 more in pre-clinical development. Hence an attempt has been made in this Booklet to explore the emerging technique of nanotechnology in vaccine design and manufacturing to combat SARS-CoV-2, and highlight opportunities and challenges presented by these novel vaccine platforms. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)