The multi-organ pathology of the thalassaemias means that the most successful patient treatment programmes involve a number of medical staff, led by paediatricians and haematologists, but including other specialists in a multidisciplinary approach. However, this means that medical professionals not involved in such multidisciplinary groups, including primary care physicians and the staff of Accident and Emergency departments, rarely treat patients with thalassaemia. As a result, their knowledge of how to address acute complications in such patients is extremely limited. This handbook aims to provide a brief evaluation of the situations in which a thalassaemia patient may seek help beyond the specialized environment he/she is used to. The layout of the handbook is intended to enable the medical professional in a busy clinical setting to draw essential information at a glance, supporting rapid, accurate as possible, decisions on how to proceed.

Understand the rapidly growing complexities of obstetric hematology and high-risk pregnancy management, with experts in the field. Now in its second edition, this comprehensive and essential guide focuses on providing the best support for patients and clinical staff, to prevent serious complications in pregnancy and the post-partum period for both mother and baby. Wide-ranging and detailed, the guide offers discussions on basic principles of best care, through to tackling lesser-known hematological conditions, such as cytopenias and hemoglobinopathies. Updated with color illustrations, cutting-edge research, accurate blood film reproductions, and practical case studies, the revised edition places invaluable advice into everyday context. This unique resource is essential reading for trainees and practitioners in obstetrics, anesthesia, and hematology, as well as midwives, nurses, and laboratory staff. Clarifying difficult procedures for disease prevention, the guide ensures safety when the stakes are high. Reflecting current evidence-based guidelines, the updated volume is key to improving pregnancy outcomes worldwide.

Issues of thrombosis, bleeding, and transfusion are extremely common, and often complex, in critically ill patients. Haematology in Critical Care: A Practical Handbookprovidesa dependable source of expert guidance on how to handle common haematological problems seen in the critical care setting, as well as the acute care of patients with a primary haematological disorder. Full-time clinical haematologists, regularly attending on intensive care, the Editors begin with an approach to abnormal laboratory tests, following with a disease-orientated approach to topics such as coagulation and haematological malignancy. Other key topics include paediatric and neonatal care, transfusion, point of care testing and the emergency presentation of haematological disease. This title brings together two of the most highly scientific specialties in clinical practice, delivering a practical approach to these problems, and guiding the clinician through the diagnosis and management of common scenarios encountered in the ICU.

To reduce transfusion-related morbidity and mortality, it is recommended that an integrated approach to blood management is employed using all available tools to reduce a patient's exposure to donor blood. Meeting the need for a book covering the concepts of blood management as a trend towards multidisciplinary blood management, this new edition is an important resource, providing healthcare professionals with a tool to develop background knowledge in blood management, its organization, methods and tools. Practicing clinicians will be fully prepared to successfully start and run blood management programs.

Thalassemia is a very common disease first described by pediatrician Thomas Benton Cooley in 1925 who described it in a patient of Italian origin. At that time, it was designated as Cooley's anemia. George Hoyt Whipple, a Nobel prize winner, and W. L. Bradford, a professor of pediatrics at the University of Rochester, coined the term thalassemia in 1936, which in Greek means anemia of the sea (Thalassa means "sea", and emia means "blood"), due to the fact that it is very common in the area of the Mediterranean Sea. This name is actually misleading because it can occur everywhere in the world. Thalassemia is not a single disease; it is rather a group of hereditary disorders of the production of globulin chain of the hemoglobin. Throughout the world, thalassemia affects approximately 4.4 of every 10,000 live births. It represents a major social and emotional impact on the patient and his family and a major burden on health services where the prevalence is high.

The Oxford Handbook of Anaesthesia has been completely updated for the second edition. All chapters have been rewritten and a number of new expert authors have been brought on board. Additional new material includes anaesthesia for the critically ill, and a comprehensive section on anaesthetic risk including anaesthetic risk tables. The first section deals with preoperative issues affecting the administration of anaesthesia. Practical advice is provided covering the impact of medical disease on anaesthesia. The second section describes practical anaesthetic techniques for surgical specialties, including most subspecialties such as thoracic and neuroanaesthesia. Separate, comprehensive sections on paediatric and obstetric anaesthesia are included. The management of emergencies arising during anaesthesia are fully covered with helpful action plans and algorithms throughout. Uncommon conditions and their management are included, and there is an extensive drug formulary and guide to infusion drugs. As with the first edition, this new edition will be the essential handbook for anaesthetists, both junior and experienced, for registrars and those sitting exams, as well as ODPs and nurses involved in theatre area work and pre-assessment. It is the one book for anyone working in anaesthesia to keep to hand at all times!

Within the last few years, iron research has yielded exciting new insights into the understanding of normal iron homeostasis. Such development, and the evolution of improved strategies of Iron Chelating Therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant developments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload. This volume highlights the impact of long term Iron Celating Therapy using deferoxamine or the new, but controversial oral iron chelator deferiprone based on experience gained by multicenter trails, with special emphasis on survival, morbidity and drug toxicity; it reviews the development of the new and improved orally effective chelators suitable for clinical use in the near future and examines novel strategies of iron chelating treatment for the control of cell proliferation in malignant disease or malaria.

Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies is a Special Issue of the International Journal of Neonatal Screening. Sickle cell disease is one of the most common inherited blood disorders, with a huge impact on health care systems due to high morbidity and high mortality associated with the undiagnosed disease. Newborn screening helps to make the diagnosis early and to prevent fatal complications and diagnostic odysseys. This book gives an overview of diagnostic standards in newborn screening for sickle cell disease and examples of existing newborn screening programs.

Concise, current, need-to-know coverage of emergency medicine in children – presented in full colorEndorsed by the American College of Emergency Physicians "...a comprehensive and current resource for anyone who cares for children in an acute setting, from the office to the emergency department. Its presentation is straightforward, and the information is easy to read and assimilate. It will be a valuable resource for those in the field of pediatric emergency medicine as well as other practitioners who occasionally care for sick children."—JAMA (reviewing an earlier edition)This clinically-focused guide covers the entire field of pediatric emergency medicine. Featuring a strong focus on practical need-to-know information Pediatric Emergency Medicine, Fifth Edition is bolstered by numerous full-color images, bulleted High-Yield Facts at the beginning of each chapter, nearly 100 diagnostic and treatment algorithms, and treatment tables with drug dosages. Endorsed by the American College of Emergency Physicians, this book is perfect for use in the emergency department or the pediatric clinic.FEATURES•Chapters open with bulleted High-Yield Facts, followed by just enough pathophysiology for understanding, and continue with a focus on what needs to be done to protect and save the child•Broad scope spans the full spectrum of pediatric emergencies -- from trauma care to psychosocial emergencies•NEW CHAPTER on Brief Resolved Unexplained Events (BRUE)•Opens with an important symptom-based section of Cardinal Presentations that familiarizes you with crucial life-saving protocols•Covers all major categories of disease that present in children on an urgent or emergent basisIf you are in need of a very readable and easily accessible, evidence-based text written to help you provide high quality emergency medical care to children, your search ends here.