The diagnosis of mental illness is frequently accompanied by sleep problems; conversely, people experiencing sleep problems may subsequently develop mental illness. Sleep and Mental Illness looks at this close correlation and considers the implications of research findings that have emerged in the last few years. Additionally, it surveys the essential concepts and practical tools required to deal with sleep and co-morbid psychiatric problems. The volume is divided into three main sections: basic science, neuroendocrinology, and clinical science. Included are over 30 chapters on topics such as neuropharmacology, insomnia, depression, dementia, autism, and schizophrenia. Relevant questionnaires for the assessment of sleep disorders, including quality-of-life measurement tools, are provided. There is also a summary table of drugs for treating sleep disorders. This interdisciplinary text will be of interest to clinicians working in psychiatry, behavioral sleep medicine, neurology, pulmonary and critical care medicine.

This book represents the final work of the late Professor C. David Marsden, who was the most influential figure in the field of movement disorders, in terms of his contributions to both research and clinical practice, in the modern era. It was conceived and written by David Marsden and his colleague at the Institute of Neurology, Prof. Ivan Donaldson. It was their intention that this would be the most comprehensive book on movement disorders and also that it would serve as the 'clinical Bible' for the management of these conditions. It provides a masterly survey of the entire topic, which has been made possible only by vast laboratory and bedside experience. Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to rare, and very rare conditions such as Niemann-Pick disease. Chapters follow a structured format with historical overviews, definitions, clinical features, differential diagnosis, investigations and treatment covered in a structured way. It is extensively illustrated with many original photographs and diagrams of historical significance. Among these illustrations are still images of some original film clips of some of Dr. Marsden's patients published here for the first time. Comprehensively referenced and updated by experts from the Institute of Neurology at Queen Square, this book is a valuable reference for, not just movement disorder specialists and researchers, but also for clinicians who care for patients with movement disorders.

This practical question and answer book covers topics within the field of neurocritical care, including aspects of neurology, neurosurgery, general critical care, and emergency medicine. The updated second edition, with hundreds of new and revised test items, contains two full length practice exams that mimic the tone and scope of the recently introduced American Board of Psychiatry and Neurology (ABPN) certifying exam in Neurocritical Care, based on approval from the American Board of Medical Specialties (ABMS). At the conclusion of each exam, answer choices, rationale, and references are provided. The book is geared towards critical care fellows, but may also be useful for residents in the fields of neurology, neurosurgery, emergency medicine, and internal medicine.

Essential Anesthesia is a concise, accessible introduction to anesthetic practice. Now in its second edition, it provides a thorough overview of the science and practice of anesthesia. Part I describes the evaluation of the patient, the different approaches to anesthesia, and the post-operative care of the patient in pain. Part II introduces the essentials of physiology and pharmacology and their role in understanding the principles of anesthesia. The final part presents a step-by-step description of 14 clinical cases. These clinical vignettes give a very real introduction to the practicalities of anesthesia and will give the non-anesthetist physician an idea of how to prepare a patient for a surgical procedure. All chapters have been expanded and updated and an entirely new chapter on safety in healthcare has been added. This is the perfect introductory text for medical students, junior doctors and all operating theatre and critical care staff.

An AIDS vaccine is still elusive and HIV treatment continues to develop multidrug resistance at alarming rates. Because of the similarities between HIV and immune deficiency infections in a variety of animals, it is only natural that scientists use these animals as models to study pathogenesis, treatment, vaccine development and many other aspects of HIV. Part of the series Infectious Agents and Pathogenesis, this volume reviews the immune deficiency virus in a variety of hosts. Pathogenesis, vaccine and drug development, epidemiology, and the natural history of the monkey, mouse, cat, cow, horse, and other animal viruses are detailed and compared to HIV. Also included are chapters on the history and future of animal models, as well as a chapter on ethical and safety considerations in using animal models for AIDS studies.

This textbook covers the basic sciences of physics and pharmacology, as well as anaesthesia for all the specialized fields of surgery. Although the practice of anaesthesia can only be perfected by administering anaesthesia to patients, this publication covers the theoretical knowledge that determines to a large extent the quality of practical skill. In addition, it includes in-theatre instruction vital to safe anaesthetic practice. Twenty one chapters contain a stand-alone account of specific anaesthesia of each particular physical system. Material is structured to include clinical features, pathophysiology, diagnostic tests and preoperative assessment, anaesthetic implications and complication, techniques, monitoring, management and post-operative care. Covering ideal, complex and emergency conditions, the advantages and disadvantages of various terchniques are set out to enable the practitioner to come to an informed decision.

Designed for easy transport and quick reference, Pocket Anesthesia, presents essential information that residents, anesthesiologists, CRNAs, and medical students need on the wards and in the operating room. Edited by anesthesia faculty at Harvard Medical School, this pocket-size reference is ideally suited for today's fast-paced anesthesia environment--it is concise, easy to read, and evidence-based. Essential information is presented in a well-organized schematic outline format with many tables, algorithms, and diagrams. The book is filled with must-know facts about drugs, frequent intraoperative problems, differential diagnosis, common disease states, patient evaluation, and anesthetic considerations for each subspecialty. New to the revised, second edition, is the inclusion of ultraound-guided regional anesthesia procedures.

Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.