The purpose of this book is to provide comprehensive coverage and an update of the major roles of eicosanoids in reproduction. It presents considerable evidence of the importance of lipoxygenase metabolites of arachidonic acid metabolism in reproductive processes. This interesting volume embraces a multidisciplinary approach to research in reproduction (biochemistry, endocrinology, physiology, pharmacology, etc.) at all levels, from whole animal studies through organ, cellular, and molecular approaches. This one-of-a-kind work provides several clinically relevant chapters and places emphasis on the relevance to human reproduction, when applicable. This text is an excellent update for researchers and clinicians on the current state of knowledge of the role of eicosanoids in mechanisms critical for successful reproductive function. This informative, easy-to-read resource is also useful to all those with a more specific interest in obstetrics, gynecology, clinical endocrinology, and the study of fertility.

The original series, Advances in Prostaglandin Research, edited by Sultan M. M. Karim, was published by MTP Press in three volumes in 1975 and 1976. A glance at those books illustrates the progress that has been made since then. The thromboxanes were mentioned twice (first publication 1975) and prostacyclin not once (first publication 1976); leukotrienes were only on the horizon. The amazing generation of research data in the last 10-15 years has given new, broad insights into many areas, including asthma, inflammation, renal, cardiovascular and gastrointestinal diseases and in reproduction, and has led in some instances to real clinical benefit. This series, Advances in Eicosanoid Research, reflects the current understanding of prostaglandins , thromboxanes and leukotrienes. The aim is to provide an introductory background to each topic and the most up-to-date information available. Although each book stands alone, the eicosanoids cut across many boundaries in their basic actions; selected chapters from each book in the series will provide illuminating and productive information for all readers which will advance their education and research. In the production of this series, I must acknowledge with pleasure my collaboration with editors and authors and the patient endeavours of Dr Michael Brewis and the staff at MTP Press. KEITH HlLUER University of Southampton England ix Preface This book is an appraisal of areas in human reproduction where eicosanoid studies (prostaglandins, leukotrienes and thromboxanes) are contributing to physiological and pathological awareness and clinical advances.

The purpose of this book is to provide comprehensive coverage and an update of the major roles of eicosanoids in reproduction. It presents considerable evidence of the importance of lipoxygenase metabolites of arachidonic acid metabolism in reproductive processes. This interesting volume embraces a multidisciplinary approach to research in reproduction (biochemistry, endocrinology, physiology, pharmacology, etc.) at all levels, from whole animal studies through organ, cellular, and molecular approaches. This one-of-a-kind work provides several clinically relevant chapters and places emphasis on the relevance to human reproduction, when applicable. This text is an excellent update for researchers and clinicians on the current state of knowledge of the role of eicosanoids in mechanisms critical for successful reproductive function. This informative, easy-to-read resource is also useful to all those with a more specific interest in obstetrics, gynecology, clinical endocrinology, and the study of fertility.

Polyunsaturated fatty acids are essential for human cell metabolism. As precursors of a very large and extremely versatile family of signaling compounds they play a key role in intracellular communication. Eicosanoids constitute one of the most abundant and prominent subfamilies of these fatty acid derivatives which are formed primarily along oxidative pathways. Prostaglandins, leukotrienes, and related eicosanoids have a modulatory function in mammalian cells and are responsible for tissue responses such as inflammation or wound repair. Increasing activity in eicosanoid research sheds new light on today's most common diseases including atherosclerosis, cancer, Alzheimer's, allergies, and rheumatic diseases. The recent advances already have far-reaching implications in medicine. This detailed account, written by leading experts, covers the ground-breaking developments in recent eicosanoid research. The topics span eicosanoid biogenesis, new aspects of their pathophysiology, for example their influence on the cardiovascular system, as well as the clinical application of synthetic eicosanoids and their antagonists. Researchers and students working in biochemistry or in pharmaceutical, physiological, medicinal and neurochemistry will value this informative introduction to one of the most rapidly developing fields in cell biology.

Eicosanoids are a diverse group of biologically active molecules derived from polyunsaturated fatty acid precursors. This volume draws together for the first time a series of overviews on the biosynthesis and functional significance of these and related compounds in a wide range of animals, plants, and micro-organisms. All chapters are written by recognized experts in their fields, and many make use of significant amounts of unpublished materials. This volume is aimed at advanced undergraduates and at researchers interested in lipid biochemistry and general plant and animal biology. Originally published in 1999. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

This volume generates a new paradigm for researching and understanding the biological meaning of eicosanoids. Eicosanoid is a general term for oxygenated metabolites of certain polyunsaturated fatty acids. The compounds are extremely important in human biology, in which they are well understood. Their importance to humans, however, has tended to overshadow their broader biological significance. David Stanley seeks to change that in this book, providing a general sketch of the medical background on eicosanoids and then developing a detailed critical treatment of eicosanoid actions in invertebrates and some lower vertebrates. Stanley looks at the role of eicosanoids in, for example, invertebrate reproduction, immunity, and ion transport physiology. As he explains, eicosanoids also mediate important ecological interactions, particularly host-parasite interactions. Drawing on these physiological and ecological actions, the book develops a "biological paradigm," under which we understand that eicosanoids probably exert important actions in most, if not all, animals. Because eicosanoids mediate crucial events in the lives of animals, they are endowed with unusual explanatory power. Research designed to increase our understanding of eicosanoids has thus yielded and will continue to yield important new information about animal biology. In addition to representing a major advance in our understanding of eicosanoids in animals, this book serves as an unusually comprehensive and accessible introduction to eicosanoid research in general. Originally published in 1999. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Yen & Jaffe’s Reproductive Endocrinology helps you successfully diagnose and manage the spectrum of female and male reproductive system diseases, from impaired fertility, infertility, and recurrent pregnancy loss through problems of sexual development, puberty, menstrual disturbances, fibroids, endometriosis, and reproductive aging. This trusted endocrinology reference book is ideal for studying or as a quick reference when making daily diagnostic and therapeutic decisions, ensuring it's just the resource you need to offer your patients the best possible care. Apply the latest reproductive endocrinology advances in basic and clinical science, including molecular, cellular, and genetic concepts, and grasp their relevance to pathophysiology, diagnosis, and therapy. Maximize fertility in women and men undergoing chemotherapy and other cancer treatments, and counsel patients on environmental factors affecting reproduction. Stay on top of recent developments including the impact of obesity on fertility; ovarian tissue banking; cryopreservation; pre-implantation genetic diagnosis; ovulation induction; and risks and treatments for steroid hormone-responsive cancers. View basic anatomic structures, endocrine processes, and cell function and dysfunction with absolute clarity through full-color illustrations and new images throughout. Confidently perform procedures through expanded coverage of reproductive and infertility surgery. Apply the latest reproductive endocrinology advances in basic and clinical science, including molecular, cellular, and genetic concepts, and grasp their relevance to pathophysiology, diagnosis, and therapy. Maximize fertility in women and men undergoing chemotherapy and other cancer treatments, and counsel patients on environmental factors affecting reproduction. Stay on top of recent developments including the impact of obesity on fertility; ovarian tissue banking; cryopreservation; pre-implantation genetic diagnosis; ovulation induction; and risks and treatments for steroid hormone-responsive cancers. View basic anatomic structures, endocrine processes, and cell function and dysfunction with absolute clarity through full-color illustrations and new images throughout.

Thoroughly revised and now enhanced with color artwork, this new edition offers the latest information on the diagnosis and management of reproductive endocrine disorders. As an Expert Consult title, it includes convenient online access to the complete text of the book along with all of the images and references linked to Medline.

Yen Jaffe's Reproductive Endocrinology helps you successfully diagnose and manage the spectrum of female and male reproductive system diseases, from impaired fertility, infertility, and recurrent pregnancy loss through problems of sexual development, puberty, menstrual disturbances, fibroids, endometriosis, and reproductive aging. This trusted endocrinology reference book is ideal for fellows, endocrinologists, or as a quick reference when making daily diagnostic and therapeutic decisions. It is just the resource you need to offer your patients the best possible reproductive care. "This new edition helps the reader to stay on top of recent developments. It is a must for subspecialists in reproductive medicine and a valuable source of information in the library of any department and clinical unit involved in reproductive medicine." Reviewed by Acta Obstetricia et Gynecologica Scandinavica February 2015 "It is a must for subspecialists in reproductive medicine and a valuable source of information in the library of any department and clinical unit involved in reproductive medicine." Reviewed by Acta Obstetricia et Gynecologica Scandinavica , March 2015 Get unmatched guidance you can trust, such as fresh insights into today's field and future advances, through the knowledge gleaned from worldwide fertility experts in reproductive medicine. Further your study of Reproductive Endocrinology with a list of suggested readings at the end of each chapter. Conveniently access the fully searchable text and view all of the images online at Expert Consult. Apply the latest reproductive endocrinology advances in basic and clinical science, including molecular, cellular, and genetic concepts, and grasp their relevance to pathophysiology, diagnosis, and therapy. Maximize fertility in women and men undergoing chemotherapy and other cancer treatments, and counsel patients on environmental factors affecting reproduction. Stay on top of recent developments including the impact of obesity on fertility; ovarian tissue banking; cryopreservation; pre-implantation genetic diagnosis; ovulation induction; and risks and treatments for steroid hormone-responsive cancers. View basic anatomic structures, endocrine processes, and cell function and dysfunction with absolute clarity through full-color illustrations and new images throughout. Confidently perform procedures through expanded coverage of reproductive and infertility surgery and online videos demonstrating key techniques.

This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).