This book presents a circumspective overview and update of the present existing knowledge of the biology, chemistry and pathophysiology of the dental pulp. It details numerous observations of a group of highly specialized investigators who have united in the common purpose of presenting their observations for the benefit of clinicians, teachers, researchers and students. Fortunately, the dental literature presents abundant research findings about pulp biology and the pulp's responses to various stimuli. This abundance has resulted in an increased interest and expansion of research on this subject. For example, publications abound on the response of pulp tissue to various medications and to a variety of types of dental materials which may be placed near to or at some distance from the pulp through the medium of dentine. One of the reasons the pulp is of such interest is that it not only provides the vitality to the teeth but also produces the dentine - both the primary and secondary, as well as reparative. The latter-type dentine is a result of the pulp's functions in response to disease as the former dentine is in response to health. As an example, some investigators have reported the effects of cutting of dentine and the placement of restorations in dentine which in turn reflect changes on the pulp tissue. These reports have raised a number of questions, which in turn have created a need for answers.

This book provides a detailed update on our knowledge of dental pulp and regenerative approaches to therapy. It is divided into three parts. The pulp components are first described, covering pulp cells, extracellular matrix, vascularization and innervation as well as pulp development and aging. The second part is devoted to pulp pathology and includes descriptions of the differences between reactionary and reparative dentin, the genetic alterations leading to dentinogenesis imperfecta and dentin dysplasia, the pulp reaction to dental materials, adverse impacts of bisphenol A and the effects of fluorosis, dioxin and other toxic agents. The final part of the book focuses on pulp repair and regeneration. It includes descriptions of various in vitro and in vivo (animal) experimental approaches, definition of the pulp stem cells with special focus on the stem cell niches, discussion of the regeneration of a living pulp and information on new strategies that induce pulp mineralization.

Dental caries, periodontitis, tooth loss, and bone resorption are considered prevalent health problems that have direct affect on the quality of life. While, advances in stem cell biology and biotechnology have sparked hope for devastating maladies, such as diabetes, cardiovascular diseases, etc., it also provides a strategy of regenerative therapy for dental tissues. From the prospective of tissue engineering, it is of utmost importance to understand and emulate the complex cell interactions that make up a tissue or organ. Unlike other tissues in the body, dental tissues are unique in their development, function, and even in their maintenance throughout life. The harmonized stimulations of biology and mechanical regulators to promote cellular activities have matured our understanding of the value of regenerative therapy of dental tissue versus the reparative treatment. In this book, we review the current knowledge available to regenerate alveolar bone, periodontal structure, and pulp/dentin complex. The book provides researchers with detailed information about development and functional characteristics of the dental unit with detailed protocols covering a comprehensive range of various approaches to engineer dental tissues: to use isolated cells or cell substitutes as cellular replacement, to use acellular biomaterials capable of inducing tissue regeneration, and/or to use a combination of cells, biomaterial and growth factors. We are well aware, with the concept changes in the field toward in-vitro biomimetics of in-vivo tissue development. The theoretical frame work integrating these concepts of developmental biology and developmental engineering is yet to be emphasized and implemented. Until this happens, we consider this book of regenerative dentistry as a call for scientists to achieve, researchers to innovate, practitioners to apply, and students to learn the art and science of regenerative therapy in dentistry. Table of Contents: Introduction to Regenerative Dentistry / Tissue Engineering Alveolar Bone / Tissue Engineering of the Periodontal Tissues / Dynamics for Pulp-Dentin Tissue Engineering in Operative Dentistry

Endodontics is the prevention, diagnosis and management of diseases of the tooth pulp and the tissues surrounding the root of a tooth. This new edition is a complete guide to endodontics for dental students. Divided into 39 chapters, the book covers numerous procedures and case studies and the text is further enhanced by more than 1500 clinical photographs, diagrams and tables. The fourth edition has been fully revised, and new topics added, to provide students with the latest information and advances in the field. Key points and clinical tips are highlighted for each topic and questions are included at the end of each chapter to assist exam preparation. Key points Complete guide to endodontics for dental students Fully revised, new edition providing latest advances in the field Includes more than 1500 clinical photographs, diagrams and tables Previous edition (9789350909522) published in 2013

This book is a comprehensive guide to BiodentineTM, an innovative biocompatible and bioactive material based on pure tricalcium silicate that can permanently replace dentin and can also serve as a temporary enamel substitute. Although BiodentineTM has been widely used across the world for the past decade, this is the first book to be devoted to its properties, interactions with the soft and hard tissues, and its multiple clinical applications. The coverage encompasses applications in primary and permanent teeth, in specialties as diverse as restorative dentistry, endodontics, paediatric dentistry, dental traumatology, and prosthetic dentistry. BiodentineTM application both in vital pulp therapy and endodontic procedures is illustrated and clinical step by step protocols are provided. The book provides a detailed update on BiodentineTM use to preserve the pulp vitality in direct/indirect pulp capping, pulpotomy and irreversible pulpitis treatment. It also details BiodentineTM use for non-vital teeth treatment in indications such as root/furcation perforation repair, apexification as well as in regenerative endodontic procedures. BiodentineTM: Properties and Clinical Applications will be a rich source of guidance and information for all dentists as well as dental students and academics.

The second edition of Textbook of Endodontology continues the aim of serving the educational needs of dental students and dental practitioners searching for updates on endodontic theories and techniques. Significantly restructured and completely updated, the new edition maintains the ethos of the original, facilitating ease of learning through pedagogical features such as annotated references, core concepts and key literature. It features a number of new chapters on topics ranging from outcomes of endodontic treatment to managing endodontic complications to dental trauma. Additionally, all other chapters have been thoroughly revised and brought up to date to reflect contemporary knowledge and practice. Textbook of Endodontology continues its important function of providing lucid scholarship and clear discussion of biological concepts and treatment principles in endodontics, and as such will be an important update to its current readers and a valuable discovery to its new audience.

First multi-year cumulation covers six years: 1965-70.

Nearly three decades ago, Samuel Seltzer and I. B. Bender pioneered the concept of developing biologically based recommendations for the clinical practice of endodontics and restorative dentistry. This concept was the cornerstone of their classic textbook, "The Dental Pulp". "Seltzer and Bender's Dental Pulp" represents the evolution of that book and of the philosophical principles on which it was based. Today we know that pulp tissue plays a central role in both local and systemic health. This book presents the latest research on the dental pulp and its interaction with other tissues. Each chapter provides an introduction to its major themes for the busy clinician or dental student, as well as a set of biologically based clinical recommendations for restorative and endodontic procedures. Practicing clinicians need this information to provide accurate diagnoses and effective treatment to their patients.

Written by the top experts in their fields, this is the first comprehensive text in the area of experimental endodontics. It provides detailed information on methodology and interpretation on the structure and function of dentin and the dental pulp. Articles give extensive coverage to endodontic neuroanatomy, neurophysiology, and microcirculation. The book supplies in-depth information on bacteriology and immunology for readers interested in endodontic microbiology. Extensive guidance is given also in the area of endodontic biomaterials and biocompatibility. Experimental Endodontics is an essential reference source for students, researchers and clinicians needing up-to-date literature in laboratory research methodologies.