Excerpt from Dr. H. Gross' Comparative Materia Medica In comparison to that which is not known, the knowledge of all physicians in this world is certainly small. But we should never be able to enlarge upon the existing basis, did we deny, as do the skeptics upon principle, the general certainty of cognition in medical science, or, to speak practically, the reliability of experience in the medical art. True, there are many trifles connected with the demeanor of the physician, either winning or destroying confidence, without the observance of which even the most distinguished experience and ability cannot captivate the public. Such a boon is usually somewhat dependent upon innate individuality, though sometimes acquired or developed. It would be unjust to denounce bluntly the use of these outward expedients by the cheap name of "charlatanry;" they deserve this designation only when not based upon a solid, scientific foundation, - a foundation which, however, cannot be present, or at least not apparent, where skepticism is raised to a dogma; or, where no connection has yet been found between theory and practice. But to return: in accordance with his experience, every physician cures as best he is able. In this respect we are in favor of the widest toleration, claiming the same for ourselves. No one is justified in marking out purely arbitrary paths in science, because these are mutually opposed as much as are anarchy and rational liberty. Hohenheim's doctrine did not become the common property of all physicians, because it was enveloped by a mysterious obscurity. Homoeopathy has no such fate to fear since she has a widely diffused "Press" as an ally. - Great, but not insurmountable, are the difficulties which, until now, have prevented her universal recognition and practical application. In so far as these difficulties lie in the Materia Medica, which, indeed, to the novice appears a chaos, I hope to remove them in a great measure by the present work. Our treasury of remedies has grown so much, both extensively and intensibly, that the publication of further provings of new remedies seems only exceptionally desirable. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.

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From the author of How We Die, the extraordinary story of the development of modern medicine, told through the lives of the physician-scientists who paved the way. How does medical science advance? Popular historians would have us believe that a few heroic individuals, possessing superhuman talents, lead an unselfish quest to better the human condition. But as renowned Yale surgeon and medical historian Sherwin B. Nuland shows in this brilliant collection of linked life portraits, the theory bears little resemblance to the truth. Through the centuries, the men and women who have shaped the world of medicine have been not only very human, but also very much the products of their own times and places. Presenting compelling studies of great medical innovators and pioneers, Doctors gives us a fascinating history of modern medicine. Ranging from the legendary Father of Medicine, Hippocrates, to Andreas Vesalius, whose Renaissance masterwork on anatomy offered invaluable new insight into the human body, to Helen Taussig, founder of pediatric cardiology and co-inventor of the original "blue baby" operation, here is a volume filled with the spirit of ideas and the thrill of discovery.

Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".