Double Blind follows three close friends and their circle through a year of extraordinary transformation. Set inLondon, Cap d'Antibes, Big Sur, and a rewilded corner of Sussex, this thrilling, ambitious novel is about the headlong pursuit of knowledge—for the purposes of pleasure, revelation, money, sanity, or survival—and the consequences of fleeing from what we know about others and ourselves. When Olivia meets a new lover just as she is welcoming her best friend, Lucy, back from New York, her dedicated academic life expands precipitously. Her connection to Francis, a committed naturalist living off the grid, is immediate and startling. Eager to involve Lucy in her joy, Olivia introduces the two—but Lucy has received shocking news of her own that binds the trio unusually close. Over the months that follow, Lucy’s boss, Hunter, Olivia’s psychoanalyst parents, and a young man named Sebastian are pulled into the friends’ orbit, and not one of them will emerge unchanged. Expansive, playful, and compassionate, Edward St. Aubyn's Double Blind investigates themes of inheritance, determinism, freedom, consciousness, and the stories we tell about ourselves. It is as compelling about ecology, psychoanalysis, genetics, and neuroscience as it is about love, fear, and courage. Most of all, it is a perfect expression of the interconnections it sets out to examine, and a moving evocation of an imagined world that is deeply intelligent, often tender, curious, and very much alive.

View our feature on Ann Aguirre’s Doubleblind.As a “Jumper” who navigates ships through grimspace, Sirantha Jax is used to kicking ass. So why is she suddenly chosen as an ambassador of peace?

Doubleblind is #6 in the Georgia Davis PI Series. With little work during the pandemic, Chicago PI Georgia Davis agrees to help the best friend of fellow sleuth, Ellie Foreman. Susan Siler’s aunt died suddenly after her Covid booster, and Susan’s distraught mother wants the death investigated. However, Georgia’s investigation is interrupted by a family trip to Nauvoo, Illinois, the one-time Mormon heartland. It’s there that her life unexpectedly intersects with the runaway spouse of a Mormon Fundamentalist. " Terrific scenes with Georgia's family and boyfriend add depth and layers to a memorable cast of characters." BookReporter Back in Evanston, after Georgia is almost killed by a hit and run driver, she discovers that she and the escaped woman look remarkably alike. Is someone trying to kill Georgia because of her death investigation? Or is it a case of mistaken identity? And how can Georgia find her doppelganger before whoever wants them both dead tries again? "Combining an up-to-the-minute tale of crime in the COVID era with fundamentalist Mormon noir (there's a phrase I never thought I'd find myself using!), Hellmann has put together an engrossing story that will appeal to her regular readers and win her new ones." Deadly Pleasures Magazine  If you like Tess Gerritsen, Karin Slaughter, and Lisa Gardener, you'll love Libby Hellmann's Compulsively Readable Thrillers.

A breakthrough account of how women can overcome the social binds that block their success. As Kathleen Hall Jamieson explores society's interlaced traps and restrictions, she draws on hundreds of interviews with women from all walks of life to show the ways they can cut through the restrictions.

The International Mystery Double Blind: The Icelandic Manuscript Murders is a wild ride through the cultural landscape of Iceland, from rural farmsteads to icy fjords to the high-tech world of DNA forensics. A young boy disappears in the chill of North Iceland. Twenty years later, a mysterious poem lands on the desk of his twin sister Brynja, a forensic geneticist, and rekindles her hopes that her brother might be alive. As Brynja unravels the clues, more poems arrive, each bearing dire consequences for those who receive them: the guard of the medieval manuscript of Icelandic sagas that may have the answer to her burning question, the prime minister's secretary, the local pastor. Is the poet out to stop Brynja from finding her brother and shut down her access to the DNA database? Or is the verse maker simply a psychopath copycat killer? Fighting the visual auras that have plagued her since childhood and now threaten everything she holds dear, Brynja must summon the strength to navigate the twisted labyrinth of the poet's mind and confront the dark secret buried in her family's past.

This is an open access title available under the terms of a CC BY-NC 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this manual, practical issues in trial design and conduct are discussed fully and in sufficient detail, that Field Trials of Health Interventions may be used as a toolbox' by field investigators. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience. Available as an open access book via Oxford Medicine Online, this new edition is a comprehensive revision, incorporating the new developments that have taken place in recent years with respect to trials, including seven new chapters on subjects ranging from trial governance, and preliminary studies to pilot testing.

As the carrier of a rare gene, Sirantha Jax has the ability to jump ships through grimspace-a talent which makes her a highly prized navigator for the Corp. Then a crash landing kills everyone on board, leaving Jax in a jail cell with no memory of the crash. But her fun's not over. A group of rogue fighters frees her...for a price: her help in overthrowing the established order.

Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.

Know when to show your hand…and when to hedge your bets. Randy Jansen can’t stand to just sit by and watch as a mysterious man throws money away on the roulette wheel, especially since Randy’s got his own bet going as to the reason this guy is making every play like it’s his last day on earth. The man’s dark desperation hits Randy right in the gut. Half of him warns that getting involved is a sucker’s bet, and the other half scrambles for a reason—any reason—to save the man’s soul. Ethan Ellison has no idea what he’s going to do with himself once his last dollar is gone—until Randy whirls into his life with a heart-stealing smile and a poker player’s gaze that sees too much. Randy draws Ethan into a series of wagers that leads to a scorching kiss by midnight, but he isn’t the only one with an interest in Ethan’s vulnerability. Soon they’re both taking risks that not only play fast and loose with the law, but with the biggest prize of all: their hearts.

In recent years, the paranormal has gained new footing as reality television has grabbed onto this research and created a cultural frenzy around it. There are those who are skeptics, those who believe, and those who seek to prove the existence of the paranormal. In The Double-Blind Ghost Box, authors Shawn Taylor and Daniel Morgan share their research and personal experiences with the paranormal, focusing on the development and use of the ghost box, a device that can establish a two-way communication beyond death’s veil. The Double-Blind Ghost Box reviews the process of Taylor and Morgan’s studies of the device, along with how they determined its usefulness in researching the paranormal. They explore the history of the ghost box and the issues arising in today’s ghost box methods, and they offer methods for conducting an objective ghost box investigation, processing ghost box evidence, analyzing the findings, and presenting the results to clients. Taylor and Morgan also discuss the different spirits an investigation might uncover and future ghost box applications and technologies. Sharing actual transcripts of investigations, The Double-Blind Ghost Box works toward communicating the existence of the paranormal through objective research. Shawn Taylor has a technical background in computer hardware, software, programming, digital media, Six Sigma problem solving, statistical analysis, psychology, and counseling. Daniel Morgan earned degrees in behavioral science and electrical engineering.