Matching DNA samples from crime scenes and suspects is rapidly becoming a key source of evidence for use in our justice system. DNA Technology in Forensic Science offers recommendations for resolving crucial questions that are emerging as DNA typing becomes more widespread. The volume addresses key issues: Quality and reliability in DNA typing, including the introduction of new technologies, problems of standardization, and approaches to certification. DNA typing in the courtroom, including issues of population genetics, levels of understanding among judges and juries, and admissibility. Societal issues, such as privacy of DNA data, storage of samples and data, and the rights of defendants to quality testing technology. Combining this original volume with the new update-The Evaluation of Forensic DNA Evidence-provides the complete, up-to-date picture of this highly important and visible topic. This volume offers important guidance to anyone working with this emerging law enforcement tool: policymakers, specialists in criminal law, forensic scientists, geneticists, researchers, faculty, and students.

Gives the educated layperson a survey of DNA by presenting a brief history of genetics, an outline of techniques, and indications of breakthroughs in cloning and other DNA advances. This book helps students, business people, lawyers, and jurists gain confidence in their ability to understand and appreciate DNA technology and human genetics.

Recombinant DNA Technology is focussed on the current state of knowledge on the recombinant DNA technology and its applications. The book will provide comprehensive knowledge on the principles and concepts of recombinant DNA technology or genetic engineering, protein expression of cloned genes, PCR amplification of DNA, RFLP, AFLP and DNA fingerprinting and finally the most recent siRNA technology. It can be used by post-graduate students studying and teachers teaching in the area of Molecular Biology, Biotechnology, Genetics, Microbiology, Life Science, Pharmacy, Agriculture and Basic Medical Sciences.

Enzymes are indispensable tools in recombinant DNA technology and genetic engineering. This book not only provides information for enzymologists, but does so in a manner that will also aid nonenymologists in making proper use of these biocatalysts in their research. The Enzymology Primer for Recombinant DNA Technology includes information not usually found in the brief descriptions given in most books on recombinant DNA methodology and gene cloning. - Provides essential basics as well as up-to-date information on enzymes most commonly used in recombinant DNA technology - Presents information in an easily accessible format to serve as a quick reference source - Leads to a better understanding of the role of biocatalysts in recombinant DNA techniques

A concise, authoritative source that explores the latest advances and potential uses of DNA, as well as the ethical dilemmas surrounding the altering of genetic material. Authoritative and accessible, DNA Technology: A Reference Handbook discusses the scientific developments that have contributed to our current understanding of DNA and the wide application of such technology in numerous fields. DNA Technology explores early scientists whose work laid the foundation for Watson and Crick's groundbreaking paper, as well as subsequent researchers who have furthered our knowledge of DNA. Readers will see how DNA technology is used to catch criminals, exonerate prisoners, identify disorders, produce more effective drugs, and enhance food production. Beyond explaining the science, the book also addresses the ethical, legal, economic, and social concerns that have been raised over the power to alter life, and gives readers context and background to think through these issues for themselves. - Includes a range of primary sources including tables on genetically modified crops, position papers written by nongovernmental organizations, laws, and regulations in the United States and elsewhere in the world - Offers a listing of the most important terms used in a discussion of DNA technologies

Gene transfer research is a rapidly advancing field that involves the introduction of a genetic sequence into a human subject for research or diagnostic purposes. Clinical gene transfer trials are subject to regulation by the U.S. Food and Drug Administration (FDA) at the federal level and to oversight by institutional review boards (IRBs) and institutional biosafety committees (IBCs) at the local level before human subjects can be enrolled. In addition, at present all researchers and institutions funded by the National Institutes of Health (NIH) are required by NIH guidelines to submit human gene transfer protocols for advisory review by the NIH Recombinant DNA Advisory Committee (RAC). Some protocols are then selected for individual review and public discussion. Oversight and Review of Clinical Gene Transfer Protocols provides an assessment of the state of existing gene transfer science and the current regulatory and policy context under which research is investigated. This report assesses whether the current oversight of individual gene transfer protocols by the RAC continues to be necessary and offers recommendations concerning the criteria the NIH should employ to determine whether individual protocols should receive public review. The focus of this report is on the standards the RAC and NIH should use in exercising its oversight function. Oversight and Review of Clinical Gene Transfer Protocols will assist not only the RAC, but also research institutions and the general public with respect to utilizing and improving existing oversight processes.

This accessibly written book introduces readers to DNA—one of the most important technologies for the manipulation of all forms of life, from simple bacteria to plants and animals. It also addresses the most important social, ethical, political, economic, and other issues raised by this form of technology. The great strides made in our understanding of the structure and function of DNA in recent decades have led to applying this invaluable knowledge to use in serving humanity. For example, recent discoveries in the field of genetic editing have created the potential for the creation of life forms de novo, a possibility that results in profound ethical issues for the human race that are just beginning to be discussed. What other positive—and potentially negative—developments are coming our way with continuing advancements in DNA research? DNA Technology: A Reference Handbook provides an up-to-date historical overview and general technical background to the topic as well as a broad introduction to current issues related to the development of DNA technology, such as genetically modified organisms, the use of DNA technology in the forensic sciences, and genetic testing and genetic therapy. Written by David E. Newton, an author and former teacher who has dedicated a lifetime to authoring educational texts on science and technology, this book examines the history of DNA technology from its discovery in the 1950s to the present day and covers recent advances, such as new methods for gene editing, including CRISP-Cas9 technology. Readers need to have little or no background knowledge of the technology of genetic engineering to improve their understanding of DNA-based technologies and how DNA research influences many current issues and debates in agriculture, food science, forensics, public health, and other fields. The single-volume work is particularly well-suited to students and young adults because of the range of references included that serve further study, such as a glossary of terms, a chronology, and an extensive annotated bibliography.

Genetic engineering is a rapidly growing field in the area of biological sciences. The driving forces behind this are the challenges encountered by health sectors, agriculture, the environment, and industry. As such, accurate and comprehensive knowledge about the philosophy, principles and application of genetic engineering is indispensable for students and researchers to harness maximum opportunities from this field of science. This volume gathers together comprehensive information regarding genetic engineering from recent studies, and presents it in a coherent manner. As such, it will be of interest to undergraduate and postgraduate students and researchers working in the biological sciences.

I am very glad to present this book of Basic Concept of Recombinant DNA Technology, written according to revised syllabus of B.Sc, M.Sc(Biotechnology, Microbiology), B.Pharm, M.Pharm, M.Sc Agriculture and Veterinary in all Indian Universities. This book is also useful for the medical students. I extend my good wishes to the students and teachers of Biotechnology and Microbiology, sincerely hope that Basic Concept of Recombinant DNA Technology, will receive a warm welcome from them. I welcome comments by readers of Basic Concept of Recombinant DNA Technology, for way to improve the book and to increase its value. Such suggestions will be seriously considered in the preparation of subsequent editions. I am very grateful to Dr. Tanusri Mandal, Associate Professor and Head, Department of Biotechnology, Oriental Institute of Science and Technology, Vidyasagar University, India for useful suggestions and help made by her time to time. Finally, I would like to thanks my wife Arpita Pattanayak(De), and my sweet daughter Anindita De for continuous encouragement for completion of this book.