This book highlights the effectiveness of differential diagnosis in the degree of severity of joint pathology from a clinical, biophysical, and informational point of view. It includes the following information blocks: • Two-dimensional digital polarization microscopy of polycrystalline films of synovial fluid and determination of the coordinate distributions of the orientation and phase parameters of the microscopic image from a set of parameters of the Stokes vector. • Mueller-matrix mapping of polycrystalline films of synovial fluid and determination of a set of coordinate distributions (Mueller-matrix images (MMI)) of azimuthal-invariant elements that characterize manifestations of optical activity and linear birefringence. • Development of algorithms for polarization reproduction of distributions of linear and circular birefringence of polycrystalline films of synovial fluid. • Identification of digital statistical, correlation and wavelet criteria of polarization and Mueller-matrix differential diagnosis of the degree of severity of joint pathology. • Determination of maps of laser-induced fluorescence of synovial fluid polycrystalline films. • Identification of statistical and correlational criteria for fluorescent differential diagnosis of the degree of severity of joint pathology. • Operational characteristics of the power of the methods of azimuth-invariant polarization, Mueller-matrix and laser autofluorescence microscopy of polycrystalline films of synovial fluid.

Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamental

Optical Polarization in Biomedical Applications introduces key developments in optical polarization methods for quantitative studies of tissues, while presenting the theory of polarization transfer in a random medium as a basis for the quantitative description of polarized light interaction with tissues. This theory uses the modified transfer equation for Stokes parameters and predicts the polarization structure of multiple scattered optical fields. The backscattering polarization matrices (Jones matrix and Mueller matrix) important for noninvasive medical diagnostic are introduced. The text also describes a number of diagnostic techniques such as CW polarization imaging and spectroscopy, polarization microscopy and cytometry. As a new tool for medical diagnosis, optical coherent polarization tomography is analyzed. The monograph also covers a range of biomedical applications, among them cataract and glaucoma diagnostics, glucose sensing, and the detection of bacteria.

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Second-harmonic generation (SHG) microscopy has shown great promise for imaging live cells and tissues, with applications in basic science, medical research, and tissue engineering. Second Harmonic Generation Imaging offers a complete guide to this optical modality, from basic principles, instrumentation, methods, and image analysis to biomedical a

This third edition of the biomedical optics classic Tissue Optics covers the continued intensive growth in tissue optics—in particular, the field of tissue diagnostics and imaging—that has occurred since 2007. As in the first two editions, Part I describes fundamentals and basic research, and Part II presents instrumentation and medical applications. However, for the reader’s convenience, this third edition has been reorganized into 14 chapters instead of 9. The chapters covering optical coherence tomography, digital holography and interferometry, controlling optical properties of tissues, nonlinear spectroscopy, and imaging have all been substantially updated. The book is intended for researchers, teachers, and graduate and undergraduate students specializing in the physics of living systems, biomedical optics and biophotonics, laser biophysics, and applications of lasers in biomedicine. It can also be used as a textbook for courses in medical physics, medical engineering, and medical biology.