With cardiovascular disease becoming the most common cause of death in people with diabetes, interest in the assessment and treatment of heart disease in these patients has been reawakened. This book examines developing topics from a largely cardiological perspective, covering both pharmacological and non-pharmacological interventions. The DIGAMI study on the use of intravenous insulin infusion at the time of myocardial infarction (MI) has stimulated a large number of discussion papers on the best treatment of MI in the diabetic patient. The UKPDS has shown that treatment of Type 2 diabetes does not reduce cardiovascular end-points significantly, but that aggressive treatment of blood pressure can do so. In addition, sub-group analysis from several large cardiovascular trials has shown that treatment with statins, anti-platelet therapy, ACE inhibitors and other drugs will also reduce cardiovascular events in people with diabetes.

Diabetes has become a worldwide health problem, the global estimated prevalence approaches ten percent and the burden of this disease in terms of morbidity and mortality is unprecedented. The advances acquired through the knowledge of the mechanisms of the disease and the variety of therapeutic approaches contrast with the inability of private and public health systems in underdeveloped and even developed countries to achieve the goals of treatment. This paradox has been described in many sources: the surge of scientific advances contrast with an unprecedented amount of human suffering. Thus, a patient centered and an evidence based approach with the capacity to produce measurable clinical and economic outcomes is required. The purpose of this textbook is multiple: to offer a comprehensive resource covering all aspects of outpatient management; to address diabetes as a health problem from an epidemiological, economic and clinical perspective; to discuss the role of social determinants of health on the worldwide increase in diabetes; to highlight the challenges and obstacles in providing adequate care; and to outline a multidisciplinary approach to management in which medical visits retain their importance as part of a team comprising the patient, his or her family and a multidisciplinary group of health professionals who are able to move beyond the traditional approach of diabetes as a disease and greatly improve outcomes.

This third edition of the book offers an up-to-date review of Diabetes Mellitus with a focus on both Micro- and Macrovascular Disease. The text includes a review of the basic concepts of : Diabetes and Vascular Disease, including Endothelial Dysfunction; The Effect of Insulin on the Vascular System; The Mechanism of Atherosclerosis in Diabetes Mellitus and the Role of Inflammation on the Vascular Tree; and The Role of the Renin-Angiotensin-Aldosteronism on Diabetes Mellitus. Chapters will discuss the Genetics of Type 2 Diabetes Mellitus as well as the Metabolic Syndrome. Other chapters discuss the Risk Factors of Diabetes and Vascular Disease, including Hypertension; Dyslipidemia; and Thrombosis. The book also reviews Microcirculation; Diabetic Nephropathy; Diabetic Retinopathy; as well as the Epidemiology, Diagnosis, and Treatment of Peripheral Vascular Disease; Diabetes and Coronary Artery Disease; Diabetes and Percutaneous Interventions; Diabetes and Cardiac Surgery; and Diabetes and Heart Failure. Chapters conclude with a review of the present-day Treatment of the Diabetic Patient. Diabetes and Cardiovascular Disease, 3rd Edition, offers practicing physicians a cutting-edge scientific and clinical review of diabetic cardiovascular disease, providing both a deeper understanding of its pathology and all the day-to-day practical knowledge needed to treat patients effectively.

Cardiodiabetes refers to heart disease that develops in people who have diabetes. Compared with people who don't have diabetes, people who have diabetes are at higher risk of heart disease, have additional causes of heart disease, may develop heart disease at a younger age, and may have more severe heart disease. With nearly 1000 pages, this manual is a complete guide to the diagnosis and management of cardiodiabetes. Divided into nine sections, each chapter addresses a separate and distinct issue of clinical relevance. The book provides an insight into clinical spectrum, diagnostic methodology, management strategies, nutraceutical and obesity care, arrhythmia management, coronary intervention, cardiac surgery, rehabilitation, and future directions in cardiodiabetes care. Additionally, the text features discussion on strategies to reduce the growing prevalence of diabetes, and the current pathophysiological understanding of cardiovascular comorbidities in patients with diabetes. More than 500 clinical photographs, illustrations, tables and boxes further enhance the comprehensive text. Key points Nearly 1000 pages providing in depth discussion on diagnosis and management of cardiodiabetes Each chapter addresses a separate issue of clinical relevance Includes future directions in cardiodiabetes care Highly illustrated with more than 500 images, tables and boxes

Diabetes is a major public health problem which is expected to affect 160 million people worldwide by the year 2000. Clearly an understanding of the effects of diabetes on the heart is an important step in the development of strategies to reduce the incidence of heart disease for diabetic patients, thus increasing their overall life-expectancy and quality of life. In this book, the editors bring together the different lines of evidence supportive of the idea of a diabetic cardiomyopathy. The first chapter provides an overview of the impact of cardiac dysfunction on the mortality and morbidity of the diabetic population in general, as well as a presentation of clinical aspects of heart disease in diabetes. This is followed by chapters concerned with the pathological and functional changes that occur in the heart as a result of diabetes and a description of the various therapeutic interventions that are available to reverse the effects of diabetes on the heart. Subsequent chapters focus on changes in protein synthesis, membrane function and intermediary metabolism that take place following the onset of diabetes. Since these alterations precede many of the functional and pathological changes, it may be that the processes responsible for the functional decline and tissue injury are initiated by diabetes-induced changes at the cellular and/or biochemical level.

Diabetes and Cardiovascular Disease: Evaluation, Prevention & Management presents the epidemiologic relation of diabetes and associated risk factors with cardiovascular disease. This concise guide demonstrates the role of non-invasive imaging strategies for evaluation of cardiovascular disease risk in diabetes, and the role of nutrition and physical activity in preventing diabetes and its cardiovascular complications. Diabetes and Cardiovascular Disease: Evaluation, Prevention & Management also covers the relation of chronic kidney disease to diabetes and cardiovascular consequences, and offers glycaemic control strategies for reducing the risk of cardiovascular disease with diabetes. The wide scope of this book makes it an essential resource for diabetologists, cardiologists and physicians. Key Features Presents the relationship between diabetes and cardiovascular disease Focus on prevention and management, including chapter on quality of care and provider/medical systems in diabetes management Edited by team of experts in the field from the University of California

Diabetes in Cardiovascular Disease is a current, expert resource focusing on the complex challenges of providing cardiovascular care to patients with diabetes. Designed as a companion to Braunwald's Heart Disease, this interdisciplinary medical reference book bridges the gap between the cardiology and endocrinology communities of scientists and care providers, and highlights the emerging scientific and clinical topics that are relevant for cardiologists, diabetologists/endocrinologists, and the extended diabetes care team. - Access essential coverage of basic and clinical sciences, complemented by an expanded focus on epidemiology, behavioral sciences, health policy, and disparities in health care. - Take advantage of a format that follows that of the well-known and internationally recognized Braunwald's Heart Disease. - Review the best available clinical data and pragmatic recommendations for the prevention and management of cardiovascular complications of diabetes; national/societal intervention strategies to curb the growing prevalence of diabetes; and the current pathophysiological understanding of cardiovascular comorbidities in patients with diabetes. - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.

Cardiovascular disease is a common cause of morbidity and mortality in people with diabetes, and it is an issue that is becoming increasingly important to cardiologists and specialists in diabetes. This second edition has been updated to include new trial data, new drugs and updates on treatment of diabetes in heart failure patients.

The prevalence of obesity, metabolic syndrome and diabetes - three links of the same 'atherothrombotic chain' - has reached pandemic proportions worldwide. As a result, our civilization is at war against a threatening enemy: cardio-diabetes. Several independent physiological processes underlie the clustering of cardio-diabetes, including central obesity, insulin resistance, dyslipidemia, inflammation, impaired glucose tolerance, and hypertension. Early detection is of overwhelming importance for public health. The complex and intimate relationship between cardiovascular disease and diabetes from basic science to clinical and therapeutic concerns is discussed in this outstanding book. Beginning with molecular, biochemical, inflammatory and cellular aspects, this publication continues with histological and pathophysiological issues, details particular problems in specific metabolic and clinical settings, and finally analyzes several aspects of clinical pharmacology focusing on the optimal management of combined dyslipidemia and non-insulin antidiabetic therapy in cardiac diabetic patients. This book will be a gain in knowledge for every cardiologist, diabetologist, specialist in internal medicine, nutritionalist, general physician and medical student.

Cardiodiabetes refers to heart disease that develops in people who have diabetes. Compared with people who don't have diabetes, people who have diabetes are at higher risk of heart disease, have additional causes of heart disease, may develop heart disease at a younger age, and may have more severe heart disease. This book is a comprehensive guide to the diagnosis and management of cardiodiabetes. Comprising 36 chapters, each one focuses on a different aspect of the condition, clearly explaining pathophysiology, symptoms and investigations, clinical diagnosis, evaluation, and treatment strategies. A complete chapter is dedicated to the occurrence and management of cardiodiabetes and chronic kidney disease. The text is further enhanced by clinical images, illustrations and figures, many depicting digital interventions. Key points Comprehensive guide to diagnosis and management of cardiodiabetes Covers many aspects of the disease explaining pathophysiology, investigations, evaluation, diagnosis and management of each one Includes chapter on cardiodiabetes and chronic kidney disease Highly illustrated with clinical photographs, diagrams and figures