Proof of the efficacy of dermatological products is a prerequisite for clinical testing and registration. Now, efficacy claims for cosmetics must be equally substantiated. This book provides a concise, practical but comprehensive overview of experimental models used to screen, develop and select dermatological and cosmetic formulations. The authors are recognized specialists in their field and use a standardized approach to the projects facilitating the reading for the stressed scientist, for the R+D managers general view as well as for the beginners in the field.

Designed with practical usability in mind, Comprehensive Dermatologic Drug Therapy, 4th Edition, helps you safely and effectively treat the skin disorders you're likely to see in your practice. Dr. Stephen E. Wolverton and new associate editor Dr. Jashin J. Wu lead a team of global experts to bring you concise, complete guidance on today's full spectrum of topical, intralesional, and systemic drugs. You'll prescribe with confidence thanks to expert coverage of which drugs to use, when to use them, and adverse effects to monitor. - Includes new drug interaction tables, drug risk profiles, and FDA guidelines, as well as two new appendices that summarize chapter questions and summarize highest-risk drug interactions. - Covers the best uses for new biologic therapeutics. - Contains new chapters covering medical decision-making principles, PDE-4 and JAK inhibitors, interleukin 17 inhibitors, interleukin 23 inhibitors, additional biologic therapeutics, and hedgehog pathway inhibitors. - Contains quick-access summaries of indications/contraindications, dosage guidelines, drug interactions, drug monitoring guidelines, adverse effects, and treatment protocols. - Features a highly detailed, disease-specific index, as well as purchase information for major drugs. - Helps you assess your knowledge and prepare for certification or recertification with about 800 review questions and answers throughout the book. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.

This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.

Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.​

This manual provides an educationally focused and practically applicable resource for trainee dermatologists undertaking various dermatology board examinations. Concise, easy-to-follow chapters featuring relevant videos with editorial commentary aid the reader in developing an in depth understanding of a range of skin conditions and their management. Key concepts relevant to cutaneous neoplasms, fungal infections, dermatopharmacology, chemical peels, disorders of pigmentation and dermatopathology are all covered. Emphasis is placed on breaking topics down into modules, similar to that now taken by many dermatology board assessments for trainee dermatologists, aiding the reader easily access the content they need. Clinical Manual of Dermatology concisely describes many key concepts required to gain a thorough understanding of a range of topics in dermatology crucial to successfully completing dermatology board examinations. It is therefore, a valuable resource for all trainee dermatologists.

Written by experienced and internationally renowned contributors, this is the fourth edition of what has become the standard reference for cosmetic scientists and dermatologists seeking the latest innovations and technology for the formulation, design, testing, use, and production of cosmetic products for skin, hair, and nails. New to this fourth edition are chapters on dermatocosmetic vehicles, surface film, causes and measurement of skin aging, make-up products, skin healing, cosmetics in sports, cosmetotextiles, nutricosmetics, natural ingredients, cosmeceuticals, and regulatory vigilance.

Be sure your skin-care treatments have strong evidential support Evidence-based Dermatology, Third Edition takes a unique approach to clinical dermatology by emphasising use of only the highest quality available evidence when treating people with skin diseases. Beginning with a toolbox introduction to the practice of evidence-based dermatology, it then covers the application of evidence for dermatological treatments across a wide range of ailments, including: • Common inflammatory skin diseases • Skin cancer, moles and actinic keratoses • Infective skin disease, exanthems and infestations • Disorders of pigmentation In addition, many of the rarer skin disorders are also included so as to provide comprehensive coverage of the topic. World-leading experts in dermatology follow a clinical approach for each disease, and as well as providing their expert guidance on the description and diagnosis of dermatologic disorders, they also discuss common dilemmas that clinicians face when considering the best approach to patient management. ‘Key Points’ accompany each chapter to provide a quick review of the most important points. Clinically oriented and practically focused, Evidence-based Dermatology ensures that your treatments are entirely patient-focused and fully supported by the very latest medical evidence.

Completely revised to meet the demands of today's trainee and practicing plastic surgeon, Aesthetic, Volume 2 of Plastic Surgery, 4th Edition, features new full-color clinical photos, dynamic videos, and authoritative coverage of hot topics in the field. Editor-narrated PowerPoint presentations offer a step-by-step audio-visual walkthrough of techniques and procedures in aesthetic surgery. - Offers evidence-based advice from a diverse collection of experts to help you apply the very latest advances in aesthetic plastic surgery and ensure optimal outcomes. - Provides updated coverage of: Facelift - The male patient; Energy-based devices for body contouring; Autologous gluteal flaps for augmentation and preservation of gluteal contour; Buttock shaping with fat grafting and liposuction; and Essential elements of patient safety in Aesthetic Plastic Surgery, just to name a few. - Includes brand-new color clinical photos, videos, and lectures. - New volume editor J. Peter Rubin brings his expertise and know-how to all aspects of aesthetic surgery. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos, and references from the book on a variety of devices.

This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.