Cytochromes c are haemoproteins which carry out electron transfer in a wide variety of biological systems, necessitating different kinds of cytochrome c to fulfill different biological roles. The evolutionary relationship between cytochromes c and their host organisms are described, as well as their structural, spectroscopic and redox properties, including both electron-transfer rates and redox potentials. The treatment is aimed at the non-specialist so that both the techniques described and their application to cytochromes c can be understood. All classes of cytochrome c are dealt with to provide a comprehensive account of the field. No other text provides such a broad survey. Similar to the earlier volume "Cytochromes c: Biological Aspects" which deals with the classification, biosynthesis and biological role of cytochromes c, the present book is aimed at research workers and advanced students.

One of the most heavily researched proteins in existence, cytochrome c has proved irresistible to chemists and biophysicists for decades. This volume serves as a source book to update the vast body of literature compiled on this protein over the last 40 years. Chapters from an internationally renowned group of experts provide extensive coverage of structural studies, spectroscopic properties, thermodynamic properties, electron transfer kinetics and protein modification. "... a valuable addition to the cytochrome literature; I will certainly get a copy for my group." Dr G. R. Moore, University of East Anglia "For any and all students of the science of cytochrome c, this is an indispensable text." SIM News

Cytochrome c fulfills a central role in biological electron transport. This book draws together information from diverse disciplines in order to provide a common base for further research. The comprehensive treatment of this subject does not neglect to show the diversity of biological respirations and photosyntheses. But it also defines their unifying principles. This overview presents the evolutionary relatedness in bioenergetic systems. Such systems are discussed at the experimental level with emphasis on the interpretation of results and the methodological approaches used. No other text provides a broad survey of this central area of biology. Researchers on cytochrome c are presented with information on the impact and importance of other disciplines on their area of investigation. Advanced students gain a balanced account of biological electron transport and will be encouraged to seek new directions of research.

In this new edition of The Membranes of Cells, all of the chapters have been updated, some have been completely rewritten, and a new chapter on receptors has been added. The book has been designed to provide both the student and researcher with a synthesis of information from a number of scientific disciplines to create a comprehensive view of the structure and function of the membranes of cells. The topics are treated in sufficient depth to provide an entry point to the more detailed literature needed by the researcher. Key Features * Introduces biologists to membrane structure and physical chemistry * Introduces biophysicists to biological membrane function * Provides a comprehensive view of cell membranes to students, either as a necessary background for other specialized disciplines or as an entry into the field of biological membrane research * Clarifies ambiguities in the field

Cytochrome C: Roles and Therapeutic Implications provides a thoroughly revised, invaluable resource for university students and researchers in the life sciences, medicine and related fields. This esteemed text attempts to organize available information on this topic to help a better understanding of the role of cytochrome c oxidase and its functional interaction with cytochrome c (Cyt c), the network of oxidation-reduction processes of cyt c in the cell with an emphasis on the implications for apoptosis induction and possible roles of cyt c reducing agents as an attractive strategy to improve neurodegenerative pathologies or cancer. In this book, the authors also reviewed the advantages of cytochrome c oxidase histochemistry to disentangle brain substrates underlying different kinds of learning and memory, from memory engram being retrieved with an untrained hippocampus to its power to identify sensory areas in the teleost fish. Finally, the authors will explore different approaches in cell cultures, animal models, and clinical trials to enhance cytochrome c oxidase activity that lead to improve brain respiratory metabolism, namely, methylene blue and photobiomodulation. This volume effectively introduces basic concepts that are followed by more specific applications as the text evolves, providing the potential of cytochrome c to lead a revolution in the way neurodegenerative disorders are treated.

Cytochromes c are haemoproteins which carry out electron transfer in a wide variety of biological systems, necessitating different kinds of cytochrome c to fulfill different biological roles. The evolutionary relationship between cytochromes c and their host organisms are described, as well as their structural, spectroscopic and redox properties, including both electron-transfer rates and redox potentials. The treatment is aimed at the non-specialist so that both the techniques described and their application to cytochromes c can be understood. All classes of cytochrome c are dealt with to provide a comprehensive account of the field. No other text provides such a broad survey. Similar to the earlier volume "Cytochromes c: Biological Aspects" which deals with the classification, biosynthesis and biological role of cytochromes c, the present book is aimed at research workers and advanced students.

The first volume of the Handbook deals with the amazing world of biomembranes and lipid bilayers. Part A describes all aspects related to the morphology of these membranes, beginning with the complex architecture of biomembranes, continues with a description of the bizarre morphology of lipid bilayers and concludes with technological applications of these membranes. The first two chapters deal with biomembranes, providing an introduction to the membranes of eucaryotes and a description of the evolution of membranes. The following chapters are concerned with different aspects of lipids including the physical properties of model membranes composed of lipid-protein mixtures, lateralphase separation of lipids and proteins and measurement of lipid-protein bilayer diffusion. Other chapters deal with the flexibility of fluid bilayers, the closure of bilayers into vesicles which attain a large variety of different shapes, and applications of lipid vesicles and liposomes. Part B covers membrane adhesion, membrane fusion and the interaction of biomembranes withpolymer networks such as the cytoskeleton. The first two chapters of this part discuss the generic interactions of membranes from the conceptual point of view. The following two chapters summarize the experimental work on two different bilayer systems. The next chapter deals with the process ofcontact formation, focal bounding and macroscopic contacts between cells. The cytoskeleton within eucaryotic cells consists of a network of relatively stiff filaments of which three different types of filaments have been identified. As explained in the next chapter much has been recently learned aboutthe interaction of these filaments with the cell membrane. The final two chapters deal with membrane fusion.

Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.