Cystogenesis
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Author |
: Jong Hoon Park |
Publisher |
: Springer |
Total Pages |
: 128 |
Release |
: 2016-10-12 |
ISBN-10 |
: 9789811020414 |
ISBN-13 |
: 9811020418 |
Rating |
: 4/5 (14 Downloads) |
Synopsis Cystogenesis by : Jong Hoon Park
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Author |
: Irwin M. Arias |
Publisher |
: John Wiley & Sons |
Total Pages |
: 1144 |
Release |
: 2020-01-20 |
ISBN-10 |
: 9781119436843 |
ISBN-13 |
: 1119436842 |
Rating |
: 4/5 (43 Downloads) |
Synopsis The Liver by : Irwin M. Arias
Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.
Author |
: Cleo S. Bonnet |
Publisher |
: |
Total Pages |
: 496 |
Release |
: 2009 |
ISBN-10 |
: OCLC:870421086 |
ISBN-13 |
: |
Rating |
: 4/5 (86 Downloads) |
Synopsis Investigating the Mechanism of Renal Cystogenesis in Tuberous Sclerosis and Polycystic Kidney Disease by : Cleo S. Bonnet
Author |
: Karen F. Murray |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 511 |
Release |
: 2010-07-23 |
ISBN-10 |
: 9781603275248 |
ISBN-13 |
: 160327524X |
Rating |
: 4/5 (48 Downloads) |
Synopsis Fibrocystic Diseases of the Liver by : Karen F. Murray
In recent years there have been huge advances in the understanding of the genetic and molecular basis of the fibrocystic diseases. This volume provides a thorough review of fibrocyctic diseases that affect the liver. It contains in-depth discussions of the genetics, molecular biology, pathogenesis, histology, clinical presentations, complications of, treatment, and prognosis of the conditions affecting children and adults, and hence will be the gold-standard reference for these conditions. In addition, the histological features that distinguish these conditions from other potentially fibrosing hepatopathies are illustrated. Conditions with syndromic features involving the kidney or other organ systems are also reviewed. Thorough review of the clinical phenotypes, their presentations, treatment, potential complications of, and prognosis is discussed. Fibrocystic Diseases of the Liver will be an invaluable resource for hepatologists, gastroenterologists, nephrologists, and hepatic surgeons who care for children and adults with liver disease, as well as basic scientists in molecular genetics, hepatobiliary pathophysiology, hepatology and nephrology.
Author |
: Xin J. Zhou |
Publisher |
: Cambridge University Press |
Total Pages |
: 691 |
Release |
: 2017-03-02 |
ISBN-10 |
: 9781316613986 |
ISBN-13 |
: 1316613984 |
Rating |
: 4/5 (86 Downloads) |
Synopsis Silva's Diagnostic Renal Pathology by : Xin J. Zhou
An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.
Author |
: Annarita Di Mise |
Publisher |
: Frontiers Media SA |
Total Pages |
: 170 |
Release |
: 2024-05-29 |
ISBN-10 |
: 9782832549803 |
ISBN-13 |
: 2832549802 |
Rating |
: 4/5 (03 Downloads) |
Synopsis Molecular mechanisms underlying polycystic kidney disease: From the smallest bricks to the big scenario by : Annarita Di Mise
Author |
: David B. Mount |
Publisher |
: Elsevier Health Sciences |
Total Pages |
: 604 |
Release |
: 2008-01-01 |
ISBN-10 |
: 9781416002529 |
ISBN-13 |
: 1416002529 |
Rating |
: 4/5 (29 Downloads) |
Synopsis Molecular and Genetic Basis of Renal Disease by : David B. Mount
This companion to Brenner and Rector's The Kidney offers a state-of-the-art summary of the most recent advances in renal genetics. Molecular and Genetic Basis for Renal Disease provides the nephrologist with a comprehensive look at modern investigative tools in nephrology research today, and reviews the molecular pathophysiology of the nephron as well as the most common genetic and acquired renal diseases. A comprehensive clinical review of Medelian renal disease is also be included. Detailed review of the molecular anatomy and pathophysiology of the nephron that provides relevant basic science to consider when diagnosing and managing patients with these disorders.
Author |
: Mo Li |
Publisher |
: Frontiers Media SA |
Total Pages |
: 210 |
Release |
: 2022-11-16 |
ISBN-10 |
: 9782832505977 |
ISBN-13 |
: 283250597X |
Rating |
: 4/5 (77 Downloads) |
Synopsis Developmental Models 2.0 by : Mo Li
Dr. Ying Gu is employed by BGI-Research, all other Topic Editors declare no conflicts of interest.
Author |
: Frederick J. Suchy |
Publisher |
: Cambridge University Press |
Total Pages |
: 995 |
Release |
: 2007-05-07 |
ISBN-10 |
: 9781139464031 |
ISBN-13 |
: 1139464035 |
Rating |
: 4/5 (31 Downloads) |
Synopsis Liver Disease in Children by : Frederick J. Suchy
Completely revised new edition of the premier reference on pediatric liver disease. Liver Disease in Children, 3rd Edition provides authoritative coverage of every aspect of liver disease affecting infants, children, and adolescents. The book offers an integrated approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. Chapters are written by international experts and address the unique pathophysiology, manifestations, and management of these disorders in the pediatric population. The third edition has been thoroughly updated and features new contributions on liver development, cholestatic and autoimmune disorders, fatty liver disease, and inborn errors of metabolism. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.
Author |
: Irwin M. Arias |
Publisher |
: John Wiley & Sons |
Total Pages |
: 1156 |
Release |
: 2020-03-09 |
ISBN-10 |
: 9781119436829 |
ISBN-13 |
: 1119436826 |
Rating |
: 4/5 (29 Downloads) |
Synopsis The Liver by : Irwin M. Arias
Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.