Cystic Fibrosis (CF) is a multisystem disease whose symptoms and signs involve the gastrointestinal tract (thus affecting nutritional status), endocrine system, reproductive system and the respiratory tract (nose, sinuses and lungs). Despite new treatments, the median survival for patients with CF is less than optimal, primarily due to complications of obstructive lung disease. Currently there are approximately 60,000-80,000 people worldwide with CF. The clinical manifestations of CF are caused by dysfunction of CFTR (cystic fibrosis transmembrane conductance regulator), a multifunctional cyclic-AMP regulated ion channel protein. Over time, there has been dramatic improvement in CF patient life expectancy, in large part related to earlier diagnosis (newborn screening), better understanding of molecular genetics and underlying pathophysiology, the integrated and highly specialized Cystic Fibrosis Foundation Accredited Care Centers, and development of a wide range of new treatments and therapies, some of which target the basic CFTR defect. This edition of Pediatric Clinics of North America will offer general pediatricians and family physicians, as well as subspecialists, an update of the extraordinary progress made in the understanding and treatment of Cystic Fibrosis.

In this issue of Pediatric Clinics of North America, guest editors Drs. Peter G. Szilagyi, Sharon G. Humiston, and Tamera Coyne-Beasley bring their considerable expertise to the topic of Vaccine Hesitancy. A growing problem even before the COVID-19 pandemic, vaccine hesitancy encompasses various factors involving both researchers and practitioners: transparency in research, scientific findings, and governmental programs; effective communication strategies; addressing and understanding cultural, psychosocial, spiritual, political, and cognitive factors; and a willingness to learn the root causes and concerns about vaccine hesitancy. In this issue, top experts address these topics to help you improve vaccine confidence with your patients. - Contains 14 practice-oriented topics including COVID-19 vaccine hesitancy, vaccine hesitancy, trust, and culture; social media and vaccine hesitancy; optimizing your pediatric office for vaccine confidence; overcoming vaccine hesitancy using community-based efforts; and more. - Provides in-depth clinical reviews on vaccine hesitancy, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Pediatric Gastroenterology, An Issue of Pediatric Clinics of North America, E-Book

In collaboration with Consulting Editor, Dr. Bonita Stanton, Guest Editor Dr. Nelson L. Turcios has created a comprehensive issue on the multiple pulmonary symptoms associated with pediatric disease. In this issue of Pediatric Clinics of North America, expert authors have contributed clinical review articles that are current and timely. Articles are devoted to the following topics: Pulmonary Manifestations of Genetic Disorders in Children; Pulmonary Manifestations of Congenital Heart Disease in Children; Pulmonary Manifestations of Gastrointestinal, Pancreatic & Liver Diseases in Children; Pulmonary Manifestations of Hematologic and Oncologic Diseases in Children; Pulmonary Manifestations of Endocrine and Metabolic Diseases in Children; Pulmonary Manifestations of Immunosuppressive Diseases Other than HIV in Children; Pulmonary Manifestations of Human Immunodeficiency Virus (HIV) Infection in Children; Pulmonary Manifestations of Rheumatoid Diseases in Children; Pulmonary Manifestations of Systemic Vasculitis in Children; Pulmonary Manifestations of Neuromuscular Diseases in Children; Pulmonary Manifestations of Renal Disorders in Children; Pulmonary Manifestations of Parasitic Diseases in Children; Pulmonary Manifestations of Skin Disorders in Children; Adverse Environmental Exposure and Childhood Respiratory Health in Children; Functional Respiratory Disorders in Children; and Healthcare Inequalities in Pediatric Respiratory Diseases in Children. Pediatricians will come away with the clinical information they need to treat pulmonary conditions and manage outcomes in children with pediatric diseases.

In this issue, guest editors bring their considerable expertise to this important topic.Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

In this issue of Pediatric Clinics of North America, guest editors Drs. Huma Quraishi and Michael Chee bring their considerable expertise to the topic of Pediatric Otolaryngology. National health statistics indicate that disorders of the ear, nose, and throat are among the primary reasons children visit a physician, with ear infections ranking as the number one reason. This issue provides a comprehensive overview of otolaryngologic issues affecting children, providing the clinical information pediatricians need to make prompt diagnoses and facilitate positive patient outcomes. - Contains 14 relevant, practice-oriented topics including otitis media and myringotomy tubes; congenital sensorineural hearing loss; tethered oral tissue/ankyloglossia/tongue and lip tie; adenotonsillectomy; pediatric obstructive sleep apnea syndrome; recurrent croup; and more. - Provides in-depth clinical reviews on pediatric otolaryngology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Pediatric Clinics of North America, guest editors Drs. Roger W. Apple and Ethel G. Clemente bring their considerable expertise to the topic of Role of Psychologists in Pediatric Subspecialties. Top experts in the field highlight the interdisciplinary nature of primary care of children where psychology is a factor, placing emphasis the clinical topics, disease states, or medical specialties where mental health has a significant impact on the outcome and successful treatment of clinical issues in children. This issue offers a unique focus on collaboration between the psychologist and pediatrician to optimize outcomes. - Contains 16 practice-oriented topics including helping physicians collaborate with psychologists; psychologists' experiences in pediatric hematology-oncology; the role of psychologists in child abuse pediatrics; the critical role of psychologists in pediatric gastroenterology; the role of psychologists in pediatric sports medicine practice; and more. - Provides in-depth clinical reviews on the role of psychologists in pediatric subspecialties, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In collaboration with Consulting Editor Dr. Bonita Stanton, the Guest Editors of this issue of Pediatric Clinics of North America have comprehensively review the current and future opportunities for implementing telehealth into pediatric practice. Expert authors have written review articles that provide information based on current knowledge of implementation of technologies but also ask questions about how to implement and what potential challenges there will be. Articles are specifically devoted to: Overview of Telehealth for Pediatricians; Role of Doctor—Patient Relationship in Telehealth; Design Purpose and Design Thinking for Telehealth; How to Implement Telehealth in Pediatrics; Issues Related to Adoption of Health Apps and Telemedicine Programs; Workforce Trends and Business Model for Telehealth; Moral, Political and Economic and Social Dilemmas of Telehealth; Automated Digital Health with Big Data, Predictive Analytics and AI; Tele-rounds and Cased-Based Training; Role of Text-messaging and Messaging apps in telehealth; High-Quality Telehealth Training Programs; Technical and Regulatory Issues of Telehealth Medicine; and Global Health Perspective on Telehealth. Pediatricians will come away with the information they need to employ telemedicine in their clinical practice

In this issue of Pediatric Clinics of North America, guest editors Drs. Robert S. Kahn, Monica Mitchell, and Tina L. Cheng bring their considerable expertise to the topic of Achieving Child Health Equity. Health equity requires removing obstacles to health such as poverty, discrimination, and their consequences, including powerlessness and lack of access to good jobs with fair pay, quality education and housing, safe environments, and health care. In this issue, top experts provide up-to-date information to healthcare practitioners with the goal of implementing programs and policies to identify and address health care inequality for children. - Contains 15 practice-oriented topics including clarity on disparity of healthcare in pediatrics: who, what, when, where and how; screening and addressing social determinants of health in pediatric practice; addressing structural racism in pediatric practice; addressing health literacy in pediatric practice; LGBTQ+ and child health equity; and more. - Provides in-depth clinical reviews of achieving child health equity, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Pediatric Clinics of North America, guest editors Drs. Mary Lieh-Lai and Katherine Cashen bring their considerable expertise to the topic of Pediatric Critical Care. The most common indications for admission to the PICU include respiratory disease, cardiac disease, and neurologic disorders. In this issue, top experts in the field provide current clinical knowledge about these admissions as well as other important critical care admissions, including COVID-19. - Contains 13 relevant, practice-oriented topics including PICU pharmacology; COVID-19 in children; mechanical ventilation and respiratory support of critically ill children; cardiovascular critical care in children; neurocritical care in children; and more. - Provides in-depth clinical reviews on pediatric critical care, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.