Crystal growth technology involves processes for the production of crystals essential for microelectronics, communication technologies, lasers and energy producing and energy saving technology. A deliberately added impurity is called an additive and in different industries these affect the process of crystal growth. Thus, understanding of interactions between additives and the crystallizing phases is important in different processes found in the lab, nature and in various industries. This book presents a generalized description of the mechanisms of action of additives during nucleation, growth and aggregation of crystals during crystallization and has received endorsement from the President of the International Organization for Crystal Growth. It is the first text devoted to the role of additives in different crystallization processes encountered in the lab, nature and in industries as diverse as pharmaceuticals, food and biofuels. A unique highlight of the book are chapters on the effect of additives on crystal growth processes, since the phenomena discussed is an issue of debate between researchers

Particulate Crystal Characteristics; Fluid-particle Transport Processes; Crystallization Principles and Techniques; Crystal Formation Processes; Crystallizer Design and Operation; Solid-Liquid Separation Processes; Design of Crystallization Process Systems.

Crystallization is an important separation and purification process used in industries ranging from bulk commodity chemicals to specialty chemicals and pharmaceuticals. In recent years, a number of environmental applications have also come to rely on crystallization in waste treatment and recycling processes.The authors provide an introduction to the field of newcomers and a reference to those involved in the various aspects of industrial crystallization. It is a complete volume covering all aspects of industrial crystallization, including material related to both fundamentals and applications. This new edition presents detailed material on crystallization of biomolecules, precipitation, impurity-crystal interactions, solubility, and design.Provides an ideal introduction for industrial crystallization newcomers Serves as a worthwhile reference to anyone involved in the fieldCovers all aspects of industrial crystallization in a single, complete volume

The book presents, in a unified manner, various crystallization design methods. It discusses in detail the geometric framework for representing complex phase behavior involving multiple solutes, enantiomers, hydrates, compounds, polymorphs, and solid solutions through visualization of high-dimensional phase diagrams. It also describes how the impact of transport processes is accounted for using kinetically controlled process paths.

Crystallization is a natural occurring process but also a process abundantly used in the industry. Crystallization can occur from a solution, from the melt or via deposition of material from the gas phase (desublimation). Crystals distinguish themself from liquids, gases and amorphous substances by the long-range order of its building blocks that entail the crystals to be formed of well-defined faces, and give rise to a large number of properties of the solid. Crystallization is used at some stage in nearly all process industries as a method of production, purification or recovery of solid materials. Crystallization is practiced on all scales: from the isolation of the first milligrams of a newly synthesized substance in the research laboratory to isolating products on the mulit-million tonne scale in industry. The book describes the breadth of crystallization operations, from isolation from a reaction broth to purification and finally to tailoring product properties. In the first section of the book, the basic mechanisms - nucleation, growth, attrition and agglomeration are introduced. It ensures an understanding of supersaturation, the driving force of crystallization. Furthermore, the solubility of the substance and its dependences on process conditions and the various techniques of crystallization and their possibilities and limitations are discussed. Last but not least, the first part includes an intensive treatment of polymorphism . The second part builds on the basics, exploring how crystallization processes can be developed, either batch-wise or continuous, from solution or from the melt. A discussion of the purification during crystallization serves as a link between the two sections, where practical aspects and an insight using theoretical concepts are combined. Mixing and its influence on the crystallization as well as the mutual interference of down-stream processes with the crystallization are also treated. Finally, techniques to characterize the crop are discussed. The third part of the book is dedicated to accounts of actual developments and of carried-out crystallizations. Typical pitfalls and strategies to avoid these as well as the design of robust processes are presented.

Theory of Particulate Processes: Analysis and Techniques of Continuous Crystallization, Second Edition covers the numerous population balance-based particulate studies. This edition emerged from the notes for an industrial short course on crystallization. This book is divided into 10 chapters and begins with an outline of the methods for representation of particle distributions and a systematic approach to the predictive modeling of processes where there is a need to characterize distributions in time and space and by some identifying property. The succeeding chapters provide a specific and more elementary approach to modeling crystal size distributions, as well as the modeling the kinetics of crystal nucleation and growth rates. Other chapters discuss a wide range of system analysis and design considerations specific to crystallization for both the steady state and unsteady state. The final chapters illustrate the use of a population balance analysis to interpret data from both laboratory and process equipment. These chapters also explore a wide variety of particulate processes and systems for which the population balance analysis is useful. This book is of great value to graduate students with particulate systems course.

Solidification and Crystallization Processing in Metals and Alloys Hasse Fredriksson KTH, Royal Institute of Technology, Stockholm, Sweden Ulla Åkerlind University of Stockholm, Sweden Solidification or crystallization occurs when atoms are transformed from the disordered liquid state to the more ordered solid state, and is fundamental to metals processing. Conceived as a companion volume to the earlier works, Materials Processing during Casting (2006) and Physics of Functional Materials (2008), this book analyzes solidification and crystallization processes in depth. Starting from the thermodynamic point of view, it gives a complete description, taking into account kinetics and mass transfer, down to the final structure. Importantly, the book shows the relationship between the theory and the experimental results. Topics covered include: Fundamentals of thermodynamics Properties of interfaces Nucleation Crystal growth - in vapours, liquids and melts Heat transport during solidification processes Solidification structures - faceted, dendritic, eutectic and peritectic Metallic glasses and amorphous alloy melts Solidification and Crystallization Processing in Metals and Alloys features many solved examples in the text, and exercises (with answers) for students. Intended for Masters and PhD students as well as researchers in Materials Science, Engineering, Chemistry and Metallurgy, it is also a valuable resource for engineers in industry.

Crystallization is an important technique for separation and purification of substances as well as for product design in chemical, pharmaceutical and biotechnological process industries. This ready reference and handbook draws on research work and industrial practice of a large group of experts in the various areas of industrial crystallization processes, capturing the essence of current trends, the markets, design tools and technologies in this key field. Along the way, it outlines trouble free production, provides laboratory controls, analyses case studies and discusses new challenges. First the instrumentation and techniques used to measure the crystal size distribution, the nucleation and solubility points, and the chemical composition of the solid and liquid phase are outlined. Then the main techniques adopted to control industrial crystallizers, starting from fundamental approaches to the most advanced ones, including the multivariable predictive control are described. An overview of the main crystallizer types is given with details of the main control schemes adopted in industry as well as the more suitable sensors and actuators.

Crystallization is one of the most ancient and interdisciplinary topics of research known to mankind. Crystals can be organic or inorganic and may be produced from melts, liquid solutions, vapors or even in solid state. Notwithstanding its inherently high complexity, the crystallization process is part of our everyday lives, from ice making in our homes to the most state-of-the-art chemical and electronic industry. In this book, our purpose was to present new insights to the reader, as well as crucial and very useful information for researchers working in this field, while simultaneously creating a comprehensive text about crystallization processes which may serve as a starting point for people with different backgrounds.

Bridging the gap between theory and practice, this text provides the reader with a comprehensive overview of industrial crystallization. Newcomers will learn all of the most important topics in industrial crystallization, from key concepts and basic theory to industrial practices. Topics covered include the characterization of a crystalline product and the basic process design for crystallization, as well as batch crystallization, measurement techniques, and details on precipitation, melt crystallization and polymorphism. Each chapter begins with an introduction explaining the importance of the topic, and is supported by homework problems and worked examples. Real world case studies are also provided, as well as new industry-relevant information, making this is an ideal resource for industry practitioners, students, and researchers in the fields of industrial crystallization, separation processes, particle synthesis, and particle technology.