Cryo Em Part C
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Author |
: |
Publisher |
: Academic Press |
Total Pages |
: 423 |
Release |
: 2010-09-30 |
ISBN-10 |
: 9780123849946 |
ISBN-13 |
: 0123849942 |
Rating |
: 4/5 (46 Downloads) |
Synopsis Cryo-EM, Part C by :
This volume, along with Part A and Part B, is dedicated to a description of the instruments, samples, protocols, and analyses that belong to cryo-EM. It emphasizes the relatedness of the ideas, instrumentation, and methods underlying all cryo-EM approaches, which allow practitioners to easily move between them. Within each section, the articles are ordered according to the most common symmetry of the sample to which their methods are applied. - Includes time-tested core methods and new innovations applicable to any researcher - Methods included are useful to both established researchers and newcomers to the field - Relevant background and reference information given for procedures can be used as a guide
Author |
: |
Publisher |
: Academic Press |
Total Pages |
: 466 |
Release |
: 2010-09-30 |
ISBN-10 |
: 9780080956954 |
ISBN-13 |
: 0080956955 |
Rating |
: 4/5 (54 Downloads) |
Synopsis Cryo-EM Part A: Sample Preparation and Data Collection by :
Cryo-EM Part A: Sample Preparation and Data Collection is dedicated to a description of the instruments, samples, protocols, and analyses that belong to cryo-EM. It emphasizes the relatedness of the ideas, instrumentation, and methods underlying all cryo-EM approaches, which allow practitioners to easily move between them. Within each section, the articles are ordered according to the most common symmetry of the sample to which their methods are applied. - Includes time-tested core methods and new innovations applicable to any researcher - Methods included are useful to both established researchers and newcomers to the field - Relevant background and reference information given for procedures can be used as a guide
Author |
: |
Publisher |
: Academic Press |
Total Pages |
: 488 |
Release |
: 2016-08-26 |
ISBN-10 |
: 9780128054352 |
ISBN-13 |
: 0128054352 |
Rating |
: 4/5 (52 Downloads) |
Synopsis The Resolution Revolution: Recent Advances In cryoEM by :
cryoEM, a new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods and new developments in recording images, the creation, evaluation and validation of 3D maps from the images, model building into maps and refinement of the resulting atomic structures, and applications of essentially single particle methods to helical structures and to sub-tomogram averaging. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers research methods that determine the structures of biological molecules, a vital step for understanding their function - Contains the technical developments underpinning the advances of cryoEM and captures the exciting insights that have resulted
Author |
: |
Publisher |
: Academic Press |
Total Pages |
: 472 |
Release |
: 2010-09-30 |
ISBN-10 |
: 9780123849922 |
ISBN-13 |
: 0123849926 |
Rating |
: 4/5 (22 Downloads) |
Synopsis Cryo-EM Part B: 3-D Reconstruction by :
This volume is dedicated to a description of the instruments, samples, protocols, and analyses that belong to cryo-EM. It emphasizes the relatedness of the ideas, instrumentation, and methods underlying all cryo-EM approaches, which allow practitioners to easily move between them. Within each section, the articles are ordered according to the most common symmetry of the sample to which their methods are applied. - Includes time-tested core methods and new innovations applicable to any researcher - Methods included are useful to both established researchers and newcomers to the field - Relevant background and reference information given for procedures can be used as a guide
Author |
: Joachim Frank |
Publisher |
: World Scientific Publishing Company |
Total Pages |
: 0 |
Release |
: 2017-12-31 |
ISBN-10 |
: 9813234857 |
ISBN-13 |
: 9789813234857 |
Rating |
: 4/5 (57 Downloads) |
Synopsis Single-particle Cryo-electron Microscopy by : Joachim Frank
The book reproduces 55 of more than 300 articles written by the author, representing milestones in methods development of single-particle cryo-EM as well as important results obtained by this technique in the study of biological macromolecules and their interactions. Importantly, neither symmetries nor ordered arrangements (as in two-dimensional crystals, helical assemblies, icosahedral viruses) are required. Although the biological applications are mainly in the area of ribosome structure and function, the elucidation of membrane channel structures and their activation and gating mechanisms are represented, as well. The book is introduced by a commentary that explains the original development of concepts, describes the contributions of the author's colleagues and students, and shows how challenges were overcome as the technique matured. Along the way, the ribosome served as an example for a macromolecule with intricate structure and conformational dynamics that pose challenges for three-dimensional visualization. Toward the end of the book -- bringing us to the present time -- molecular structures with near-atomic resolution are presented, and a novel type of computational analysis, manifold embedding, is introduced. Single-particle cryo-EM is currently revolutionizing structural biology, presenting a powerful alternative to X-ray crystallography as a means to solve the structure of biological macromolecules. The book presents in one place a number of articles containing key advances in mathematical and computational methods leading up to the present time. Secondly, the development of the technique over the years is reflected by ever-expanding discoveries in the field of ribosome structure and function. Thirdly, as all histories of ideas, the history of concepts pertaining to this new method of visualization is fascinating all in itself.
Author |
: Mavis Agbandje-McKenna |
Publisher |
: Royal Society of Chemistry |
Total Pages |
: 389 |
Release |
: 2010-11-11 |
ISBN-10 |
: 9781849732239 |
ISBN-13 |
: 184973223X |
Rating |
: 4/5 (39 Downloads) |
Synopsis Structural Virology by : Mavis Agbandje-McKenna
Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.
Author |
: |
Publisher |
: Academic Press |
Total Pages |
: 465 |
Release |
: 2011-02-14 |
ISBN-10 |
: 9780123859297 |
ISBN-13 |
: 0123859298 |
Rating |
: 4/5 (97 Downloads) |
Synopsis The Unfolded Protein Response and Cellular Stress, Part C by :
This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights - This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation - The authors explain how these methods are able to provide important biological insights
Author |
: Tamir Gonen |
Publisher |
: Humana |
Total Pages |
: 350 |
Release |
: 2020-12-27 |
ISBN-10 |
: 1071609653 |
ISBN-13 |
: 9781071609651 |
Rating |
: 4/5 (53 Downloads) |
Synopsis cryoEM by : Tamir Gonen
This volume details the most up-to-date cryo-EM techniques from leading researchers. Chapters are organized into four parts with emphasis on electron cryotomography, single particle analysis, and the crystal based cryo-EM methods of 2D electron crystallography, and MicroED for the study of 3D crystals. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, CryoEM: Methods and Protocols aims to serve as an excellent resource on cryo-EM and can serve as the foundation for new researchers to this growing field in structural biology.
Author |
: Jean-Paul Renaud |
Publisher |
: John Wiley & Sons |
Total Pages |
: 1367 |
Release |
: 2020-01-09 |
ISBN-10 |
: 9781118900505 |
ISBN-13 |
: 1118900502 |
Rating |
: 4/5 (05 Downloads) |
Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud
With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
Author |
: Amit Kumar Nayak |
Publisher |
: Academic Press |
Total Pages |
: 673 |
Release |
: 2021-11-23 |
ISBN-10 |
: 9780323856386 |
ISBN-13 |
: 0323856381 |
Rating |
: 4/5 (86 Downloads) |
Synopsis Biological Macromolecules by : Amit Kumar Nayak
Biological Macromolecules: Bioactivity and Biomedical Applications presents a comprehensive study of biomacromolecules and their potential use in various biomedical applications. Consisting of four sections, the book begins with an overview of the key sources, properties and functions of biomacromolecules, covering the foundational knowledge required for study on the topic. It then progresses to a discussion of the various bioactive components of biomacromolecules. Individual chapters explore a range of potential bioactivities, considering the use of biomacromolecules as nutraceuticals, antioxidants, antimicrobials, anticancer agents, and antidiabetics, among others. The third section of the book focuses on specific applications of biomacromolecules, ranging from drug delivery and wound management to tissue engineering and enzyme immobilization. This focus on the various practical uses of biological macromolecules provide an interdisciplinary assessment of their function in practice. The final section explores the key challenges and future perspectives on biological macromolecules in biomedicine. - Covers a variety of different biomacromolecules, including carbohydrates, lipids, proteins, and nucleic acids in plants, fungi, animals, and microbiological resources - Discusses a range of applicable areas where biomacromolecules play a significant role, such as drug delivery, wound management, and regenerative medicine - Includes a detailed overview of biomacromolecule bioactivity and properties - Features chapters on research challenges, evolving applications, and future perspectives