"An inspiring and informative page-turner." –Walter Isaacson Longlisted for the FT/McKinsey Business Book of the Year Award The authoritative account of the race to produce the vaccines that are saving us all, from the #1 New York Times bestselling author of The Man Who Solved the Market Few were ready when a mysterious respiratory illness emerged in Wuhan, China in January 2020. Politicians, government officials, business leaders, and public-health professionals were unprepared for the most devastating pandemic in a century. Many of the world’s biggest drug and vaccine makers were slow to react or couldn’t muster an effective response. It was up to a small group of unlikely and untested scientists and executives to save civilization. A French businessman dismissed by many as a fabulist. A Turkish immigrant with little virus experience. A quirky Midwesterner obsessed with insect cells. A Boston scientist employing questionable techniques. A British scientist despised by his peers. Far from the limelight, each had spent years developing innovative vaccine approaches. Their work was met with skepticism and scorn. By 2020, these individuals had little proof of progress. Yet they and their colleagues wanted to be the ones to stop the virus holding the world hostage. They scrambled to turn their life’s work into life-saving vaccines in a matter of months, each gunning to make the big breakthrough—and to beat each other for the glory that a vaccine guaranteed. A #1 New York Times bestselling author and award-winning Wall Street Journal investigative journalist lauded for his “bravura storytelling” (Gary Shteyngart) and “first-rate” reporting (The New York Times), Zuckerman takes us inside the top-secret laboratories, corporate clashes, and high-stakes government negotiations that led to effective shots. Deeply reported and endlessly gripping, this is a dazzling, blow-by-blow chronicle of the most consequential scientific breakthrough of our time. It’s a story of courage, genius, and heroism. It’s also a tale of heated rivalries, unbridled ambitions, crippling insecurities, and unexpected drama. A Shot to Save the World is the story of how science saved the world.

Paperback. ISBN 978-1-912530-35-9. In this timely book, internationally renowned experts review literally every aspect of cutting edge coronavirus research providing the first coherent picture of the molecular and cellular biology since the outbreak of SARS in 2003. Essential reading for all coronavirologists as well as scientists working on other viruses of the respiratory and/or gastrointestinal tract.

This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.

This short book brings together novel cross-interdisciplinary investigation from both natural and social science, representing a true hybrid across disciplines examining the 'politics' and 'science' of COVID-19. Viruses, Vaccines, and Antivirals: Why Politics Matters considers the dynamics surrounding viruses, proposed vaccines, and antiviral therapies, contextualizing what governments have done during the COVID-19 crisis. The four basic phases of a pandemic are considered with a strong focus on COVID-19, namely the anticipating and early virus detection, containment strategies, policies to control and mitigate the spread of the virus and policies aimed at opening up society. Viruses, Vaccines, and Antivirals: Why Politics Matters examines policy developments throughout these phases in key nations worldwide and puts forward a blueprint for countries developing public policies to deal with a pandemic.

COVID-19 outbreak has become a worldwide pandemic. This book “CO-VI-D: Viruses/Vaccines” provides new and unique approach to the discussion of viruses and vaccines in the recent advent of Corona virus. COVID-19 disease is a novel viral disease that was first identified in Wuhan, China. The World Health Organization (WHO) announced its official name, Coronavirus disease 2019, abbreviated as COVID-19; ‘CO’ stands for ‘Corona’, ‘VI’ stands for ‘Virus’, and ‘D’ stands for ‘Disease’. Globally, more than 10 million people are reported to be infected by COVID-19 (WHO Coronavirus Disease Dashboard, 2020). Centers for Disease Control and Prevention (CDC, USA, 2020) (provided guidelines on how to reduce the risk of infection. It has been discovered that some people get really very sick and die, whereas to some people nothing happens even though they test positive for the virus. Through this book, we intend to explore etiology, development, and treatment of the COVID-19 disease. The specific topics will give details that could help in understanding symptoms, immunity, worldwide spread and treatments so that we could beat this invisible dangerous beast, the COVID-19.

This book focuses on cell culture-produced viral vaccines to meet the needs of the rapidly expanding research and development in academia and industry in the field. This book introduces the basic principles of vaccination and the manufacturing of viral vaccines. Bioprocessing of Viral Vaccines, will provide an overview of the advanced strategies needed to respond to the challenges of new and established viral infection diseases. The first few chapters cover the basics of virology and immunology as essential concepts to understand the function and design of viral vaccines. The core of the content is dedicated to process development, including upstream processing and cell culture of viral vaccines, downstream processing, and extensive analytical technologies specific to viral vaccines. Advanced process analytical technologies (PAT) and Quality by Design (QbD) concepts are also introduced in the context of vaccine manufacturing. The case studies included cover inactivated, attenuated vaccines exemplified by influenza vaccines, sub-unit vaccines exemplified by Virus Like Particles (VLPs: HPV vaccines) and sub-unit vaccines (Flublock), vectored vaccines: adenoviruses and Vesicular stomatitis Virus (VSV) vectored vaccines, genomic vaccines (DNA and mRNA) vaccines as developed for COVID-19 response in particular and a review of COVID-19 vaccines approved or in advanced clinical trials. This book is aimed at graduate engineers and professionals in the fields of vaccinology, bioprocessing, and biomanufacturing of viral vaccines.

This short book brings together novel cross-interdisciplinary investigation from both natural and social science, representing a true hybrid across disciplines examining the ‘politics’ and ‘science’ of COVID-19. Viruses, Vaccines, and Antivirals: Why Politics Matters considers the dynamics surrounding viruses, proposed vaccines, and antiviral therapies, contextualizing what governments have done during the COVID-19 crisis. The four basic phases of a pandemic are considered with a strong focus on COVID-19, namely the anticipating and early virus detection, containment strategies, policies to control and mitigate the spread of the virus and policies aimed at opening up society. Viruses, Vaccines, and Antivirals: Why Politics Matters examines policy developments throughout these phases in key nations worldwide and puts forward a blueprint for countries developing public policies to deal with a pandemic.

On March 11, 2020 the World Health Organization declared the COVID-19 pandemic and life as we knew it paused indefinitely. Confusion, doubts and uncertainty became daily companions as the world watched the pandemic consume country after country.At the University of British Columbia, Canada, a class of aspiring epidemiologists partnered with the professionals working at the frontline of COVID-19 healthcare and research, to examine key questions which would capture a snapshot of the historical pandemic.What caused this outbreak? How does a virus spread? What are the best potential treatments; how did we achieve the development of vaccines, and how do they work? What are the strategies to tackle a two-front war against the virus and the spread of dangerous misinformation and pseudoscience? These questions and more are examined throughout this volume.

This book discusses current evidence on human viruses and provides an extensive coverage of newly emerged viruses and current strategies for treatment. Offering a new perspective in view of the re-emergence of Ebola in African countries and Dengue in India and Pakistan, the contents include chapters on emergence, pathogenicity, epidemiology and vaccine uptake. Human Viruses: Diseases, Treatments and Vaccines: The New Insights discusses a range of viruses from the most common such as Influenza and Hepatitis to Zika, Poliomyelitis and Chikungunya among many others. It is authored by a team of experts on viral disease and will be of immense use to virologists, public health experts and clinicians.