My wish for you is to enjoy the vibrant energy that flows through you when you “nourish” your body & mind. Nourishment is the ultimate purpose of food. In this programme, I will show you how to consistently eat in a way that elevates your mind, energizes your body, & transforms your life, & how to do this freely because you ‘want’ to, not because you ‘have’ to.

This practical reference guide from experts in the field details why and how to establish successful antibiotic stewardship programs.

A clear, hands-on outline of best practices for infection prevention that directly improve patient outcomes across the healthcare continuum.

Over 98% of the human genome contains non-coding DNA sequences. For many years molecular biologists referred to this component of the genome as the “junk” DNA since it does not code for any “useful” protein product. Over the last years this notion changed significantly as scientists discovered that a large part of this DNA contains various genomic elements that have important roles in cell physiology. Genomic elements such as non-coding RNAs, transposons, splicing RNAs, DNA repeats and others were shown to play a significant role in regulating gene expression. In addition, all these elements were implicated to contribute in the pathogenesis or progression of various human diseases. In this book, the editor will attempt to describe all these genomic elements that constitute the junk DNA of the genome. For every genomic element, the physiologic role in the organism, its role in evolution and any possible involvement in human diseases will be discussed. Additionally, interaction between these elements in normal or pathologic condition will be discussed. Since a large amount of new knowledge is generated daily in regards to these genomic elements, this book will attempt to combine all the information in a single publication that can serve as a reference for future studies. The first part will discuss RNA elements such as microRNAs, long non-coding RNAs, piRNAs and splicing RNAs. The second part of the book will deal with transposons, retrotransposons and DNA transposons. Finally the third part of the book will discuss DNA elements that include DNA repeats, conserved non-coding sequences, distal genomic elements, introns, pseudogenes, CpG islands and telomeres. For miRNAs and CNVs a separate chapter will be dedicated to their role in human diseases since an extensive amount of information exists about these two elements.

The underlying technology and the range of test parameters available are evolving rapidly. The primary advantage of POCT is the convenience of performing the test close to the patient and the speed at which test results can be obtained, compared to sending a sample to a laboratory and waiting for results to be returned. Thus, a series of clinical applications are possible that can shorten the time for clinical decision-making about additional testing or therapy, as delays are no longer caused by preparation of clinical samples, transport, and central laboratory analysis. Tests in a POC format can now be found for many medical disciplines including endocrinology/diabetes, cardiology, nephrology, critical care, fertility, hematology/coagulation, infectious disease and microbiology, and general health screening. Point-of-care testing (POCT) enables health care personnel to perform clinical laboratory testing near the patient. The idea of conventional and POCT laboratory services presiding within a hospital seems contradictory; yet, they are, in fact, complementary: together POCT and central laboratory are important for the optimal functioning of diagnostic processes. They complement each other, provided that a dedicated POCT coordination integrates the quality assurance of POCT into the overall quality management system of the central laboratory. The motivation of the third edition of the POCT book from Luppa/Junker, which is now also available in English, is to explore and describe clinically relevant analytical techniques, organizational concepts for application and future perspectives of POCT. From descriptions of the opportunities that POCT can provide to the limitations that clinician’s must be cautioned about, this book provides an overview of the many aspects that challenge those who choose to implement POCT. Technologies, clinical applications, networking issues and quality regulations are described as well as a survey of future technologies that are on the future horizon. The editors have spent considerable efforts to update the book in general and to highlight the latest developments, e.g., novel POCT applications of nucleic acid testing for the rapid identification of infectious agents. Of particular note is also that a cross-country comparison of POCT quality rules is being described by a team of international experts in this field.

In the current era of complete genome sequencing, Bioinformatics and Molecular Evolution provides an up-to-date and comprehensive introduction to bioinformatics in the context of evolutionary biology. This accessible text: provides a thorough examination of sequence analysis, biological databases, pattern recognition, and applications to genomics, microarrays, and proteomics emphasizes the theoretical and statistical methods used in bioinformatics programs in a way that is accessible to biological science students places bioinformatics in the context of evolutionary biology, including population genetics, molecular evolution, molecular phylogenetics, and their applications features end-of-chapter problems and self-tests to help students synthesize the materials and apply their understanding is accompanied by a dedicated website - www.blackwellpublishing.com/higgs - containing downloadable sequences, links to web resources, answers to self-test questions, and all artwork in downloadable format (artwork also available to instructors on CD-ROM). This important textbook will equip readers with a thorough understanding of the quantitative methods used in the analysis of molecular evolution, and will be essential reading for advanced undergraduates, graduates, and researchers in molecular biology, genetics, genomics, computational biology, and bioinformatics courses.

Summary report published as technical document with reference number: WHO/HSE/PED/AIP/2014.2.

With the world in a state of emergency due to the Coronavirus pandemic, almost the entire scientific community and all governmental/intergovernmental agencies are focused on defining the most effective disease control and forecasting. However, is disease control the only or most crucial element to consider? In this Research Topic, we intend to highlight crucially important topics about Coronavirus related to its environmental dependencies, biological diversity and stability, and socio-economic outcomes, considering also information, modeling and technological aspects of the pandemic. The objective of the Research Topic is to bring together spatio-temporal biological, ecological, environmental and social aspects of Coronavirus to better understand its dynamics, shifts, systemic impacts on health and socio-economic effects. Studies via models that link Coronavirus to other viruses are welcome, in order to properly characterize the biology, ecology and environmental niche or universality of Coronavirus dynamics. We also seek prospective studies that investigate potential future spillovers of Coronavirus-like viruses by indicating risk hotspots in relation to socio-environmental determinants. Other issues focused on public health and medical aspects are welcome; however, these studies need to explicitly address the virus’ connection with the environment in order to gain insight into its ecology and evolution. Studies addressing data and modeling challenges as well as different model approaches (from machine learning to phenomenological and process-based models) have a lot of interest. Lastly, we highly encourage studies that quantitatively explore the coupled evolution of population perceptions and the associated infodemic (for instance, inferred from social media), behavior and systemic health outcomes.