This volume provides protocols for computational, statistical, and machine learning methods that are mainly applied to the study of metabolic engineering, synthetic biology, and disease applications. These techniques support the latest progress in cross-disciplinary research that integrates the different scales of biological complexity. The topics covered in this book are geared toward researchers with a background in engineering, computational analytical, and modeling experience and cover a broad range of topics in computational and machine learning approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Computational Biology and Machine Learning for Metabolic Engineering and Synthetic Biology is a valuable resource for any researcher or scientist who wants to learn more about the latest computational methods and how they are applied toward the understanding and prediction of complex biology.

Recognize market opportunities, master the design process, and develop business acumen with this 'how-to' guide to medical technology innovation. A three-step, proven approach to the biodesign innovation process - identify, invent, implement - provides a practical formula for innovation. The experiences of hundreds of innovators and companies, in the form of case studies, quotes and practical advice, offer a realistic, action-orientated roadmap for successful biodesign innovation. Real-world examples, end-of-chapter projects, and Getting Started sections guide the reader through each of the key stages of the process and provide a template to create their own new medical devices. Addressing common medical, engineering, and business challenges to develop well-rounded expertise, this book is the complete package for any biodesign entrepreneur. The text is supported by valuable resources, including up-to-date industry changes: found at ebiodesign.org.

This textbook presents solid tools for in silico engineering biology, offering students a step-by-step guide to mastering the smart design of metabolic pathways. The first part explains the Design-Build-Test-Learn-cycle engineering approach to biology, discussing the basic tools to model biological and chemistry-based systems. Using these basic tools, the second part focuses on various computational protocols for metabolic pathway design, from enzyme selection to pathway discovery and enumeration. In the context of industrial biotechnology, the final part helps readers understand the challenges of scaling up and optimisation. By working with the free programming language Scientific Python, this book provides easily accessible tools for studying and learning the principles of modern in silico metabolic pathway design. Intended for advanced undergraduates and master’s students in biotechnology, biomedical engineering, bioinformatics and systems biology students, the introductory sections make it also useful for beginners wanting to learn the basics of scientific coding and find real-world, hands-on examples.

Bioreactor Design Concepts for Viral Vaccine Production covers a range of interdisciplinary chapters from the engineering perspective of bioreactor design to the biotechnological perspectives of vector design for vaccine development. The book covers bioreactor concepts such as static systems, single-use systems, stirred tanks, perfusion, wave and packed-beds. It reviews options for efficient and economical production of human vaccines and discusses basic factors relevant for viral antigen production in mammalian cells, avian cells, and insect cells. This book will be a great resource for those interested in implemented novel bioreactor design or experimental schemes towards intensified or/and enhanced vaccine production. - Covers the fundamentals of bioreactor designs - Provides strategies for designing a successful vector-based vaccine - Discusses the applications of biological kinetics, thermodynamics and basic substrate requirements for viral vaccine production

This book includes the refereed Selected Papers of the 20th International Conference on Computer-Aided Architectural Design. INTERCONNECTIONS: Co-computing Beyond Boundaries, CAAD Futures 2023, held in Delft, The Netherlands, in July 5–7, 2023. The 43 full papers included in this book were carefully reviewed and selected from 144 submissions. They were organized in topical sections as follows: ​algorithmic architectural design; AI-powered architectural ideation; performance-based design, urban models and analysis; urban design; digital design, materials and fabrication; spatial information, data and semantics; building data analysis, visualisation, interaction; and building massing and layouts.

This book constitutes selected papers of the 19th International Conference on Computer-Aided Architectural Design Futures, CAAD Futures 2021, held in Los Angeles, CA, USA, in July 2021. The 33 revised full papers presented were carefully reviewed and selected from 97 submissions. The papers are organized in topical sections on ​past futures and present futures: research and pedagogy; past futures and present futures: aesthetics and ethics of space; architectural automations and augmentations: design; architectural automations and augmentations: fabrication; architectural automations and augmentations: environment; architectural automations and augmentations: spatial computing.

Structures and Architecture. A Viable Urban Perspective? contains extended abstracts of the research papers and prototype submissions presented at the Fifth International Conference on Structures and Architecture (ICSA2022, Aalborg, Denmark, 6-8 July 2022). The book (578 pages) also includes a USB with the full texts of the papers (1448 pages). The contributions on creative and scientific aspects in the conception and construction of structures as architecture, and on the role of advanced digital-, industrial- and craft -based technologies in this matter represent a critical blend of scientific, technical, and practical novelties in both fields. Hence, as part of the proceedings series Structures and Architecture, the volume adds to a continuous exploration and development of the synergetic potentials of the fields of Structures and Architecture. With each volume further challenging the conditions, problems, and potentials related to the art, practice, and theory of teaching, researching, designing, and building structures as vehicles towards a viable architecture of the urban environment. The volumes of the series appear once every three years, in tandem with the conferences organized by the International Association of Structures and Architecture and are intended for a global readership of researchers, practitioners, and students, including architects, structural and construction engineers, builders and building consultants, constructors, material suppliers, planners, urban designers, anthropologists, economists, sociologists, artists, product manufacturers, and other professionals involved in the design and realization of architectural, structural, and infrastructural projects.

A step-by-step, full-color guide to successful medical technology innovation with a new focus on value-based innovation and global opportunities.