Computational Retinal Image Analysis: Tools, Applications and Perspectives gives an overview of contemporary retinal image analysis (RIA) in the context of healthcare informatics and artificial intelligence. Specifically, it provides a history of the field, the clinical motivation for RIA, technical foundations (image acquisition modalities, instruments), computational techniques for essential operations, lesion detection (e.g. optic disc in glaucoma, microaneurysms in diabetes) and validation, as well as insights into current investigations drawing from artificial intelligence and big data. This comprehensive reference is ideal for researchers and graduate students in retinal image analysis, computational ophthalmology, artificial intelligence, biomedical engineering, health informatics, and more.

Computational Retinal Image Analysis: Tools, Applications and Perspectives gives an overview of contemporary retinal image analysis (RIA) in the context of healthcare informatics and artificial intelligence. Specifically, it provides a history of the field, the clinical motivation for RIA, technical foundations (image acquisition modalities, instruments), computational techniques for essential operations, lesion detection (e.g. optic disc in glaucoma, microaneurysms in diabetes) and validation, as well as insights into current investigations drawing from artificial intelligence and big data. This comprehensive reference is ideal for researchers and graduate students in retinal image analysis, computational ophthalmology, artificial intelligence, biomedical engineering, health informatics, and more. - Provides a unique, well-structured and integrated overview of retinal image analysis - Gives insights into future areas, such as large-scale screening programs, precision medicine, and computer-assisted eye care - Includes plans and aspirations of companies and professional bodies

Many approaches have been proposed to solve the problem of finding the optic flow field of an image sequence. Three major classes of optic flow computation techniques can discriminated (see for a good overview Beauchemin and Barron IBeauchemin19951): gradient based (or differential) methods; phase based (or frequency domain) methods; correlation based (or area) methods; feature point (or sparse data) tracking methods; In this chapter we compute the optic flow as a dense optic flow field with a multi scale differential method. The method, originally proposed by Florack and Nielsen [Florack1998a] is known as the Multiscale Optic Flow Constrain Equation (MOFCE). This is a scale space version of the well known computer vision implementation of the optic flow constraint equation, as originally proposed by Horn and Schunck [Horn1981]. This scale space variation, as usual, consists of the introduction of the aperture of the observation in the process. The application to stereo has been described by Maas et al. [Maas 1995a, Maas 1996a]. Of course, difficulties arise when structure emerges or disappears, such as with occlusion, cloud formation etc. Then knowledge is needed about the processes and objects involved. In this chapter we focus on the scale space approach to the local measurement of optic flow, as we may expect the visual front end to do. 17. 2 Motion detection with pairs of receptive fields As a biologically motivated start, we begin with discussing some neurophysiological findings in the visual system with respect to motion detection.

Advances in semi-automated high-throughput image data collection routines, coupled with a decline in storage costs and an increase in high-performance computing solutions have led to an exponential surge in data collected by biomedical scientists and medical practitioners. Interpreting this raw data is a challenging task, and nowhere is this more evident than in the field of opthalmology. The sheer speed at which data on cataracts, diabetic retinopathy, glaucoma and other eye disorders are collected, makes it impossible for the human observer to directly monitor subtle, yet critical details. This book is a novel and well-timed endeavor to present, in an amalgamated format, computational image modeling methods as applied to various extrinsic scientific problems in ophthalmology. It is self-contained and presents a highly comprehensive array of image modeling algorithms and methodologies relevant to ophthalmologic problems. The book is the first of its kind, bringing eye imaging and multi-dimensional hyperspectral imaging and data fusion of the human eye, into focus. The editors are at the top of their fields and bring a strong multidisciplinary synergy to this visionary volume. Their "inverted-pyramid" approach in presenting the content, and focus on core applications, will appeal to students and practitioners in the field.

VipIMAGE 2015 contains invited lectures and full papers presented at VIPIMAGE 2015 - V ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing (Tenerife, Canary Islands, Spain, 19-21 October, 2015). International contributions from 19 countries provide a comprehensive coverage of the current state-of-the-art in the fields o

Successful thermal modeling of the human eye helps in the early diagnosis of eye abnormalities such as inflammation, cataracts, diabetic retinopathy, and glaucoma-all leading causes of blindness. This book presents a unified work of eye imaging and modeling techniques that have been proposed and applied to ophthalmologic problems. It delves into various morphological, texture, higher order spectra, and wavelet transformation techniques used to extract important diagnostic features from images, which can then be analyzed by a data scientist for automated diagnosis.

This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.

This book presents cutting-edge research and applications of deep learning in a broad range of medical imaging scenarios, such as computer-aided diagnosis, image segmentation, tissue recognition and classification, and other areas of medical and healthcare problems. Each of its chapters covers a topic in depth, ranging from medical image synthesis and techniques for muskuloskeletal analysis to diagnostic tools for breast lesions on digital mammograms and glaucoma on retinal fundus images. It also provides an overview of deep learning in medical image analysis and highlights issues and challenges encountered by researchers and clinicians, surveying and discussing practical approaches in general and in the context of specific problems. Academics, clinical and industry researchers, as well as young researchers and graduate students in medical imaging, computer-aided-diagnosis, biomedical engineering and computer vision will find this book a great reference and very useful learning resource.

Introduction to Visual Computing: Core Concepts in Computer Vision, Graphics, and Image Processing covers the fundamental concepts of visual computing. Whereas past books have treated these concepts within the context of specific fields such as computer graphics, computer vision or image processing, this book offers a unified view of these core concepts, thereby providing a unified treatment of computational and mathematical methods for creating, capturing, analyzing and manipulating visual data (e.g. 2D images, 3D models). Fundamentals covered in the book include convolution, Fourier transform, filters, geometric transformations, epipolar geometry, 3D reconstruction, color and the image synthesis pipeline. The book is organized in four parts. The first part provides an exposure to different kinds of visual data (e.g. 2D images, videos and 3D geometry) and the core mathematical techniques that are required for their processing (e.g. interpolation and linear regression.) The second part of the book on Image Based Visual Computing deals with several fundamental techniques to process 2D images (e.g. convolution, spectral analysis and feature detection) and corresponds to the low level retinal image processing that happens in the eye in the human visual system pathway. The next part of the book on Geometric Visual Computing deals with the fundamental techniques used to combine the geometric information from multiple eyes creating a 3D interpretation of the object and world around us (e.g. transformations, projective and epipolar geometry, and 3D reconstruction). This corresponds to the higher level processing that happens in the brain combining information from both the eyes thereby helping us to navigate through the 3D world around us. The last two parts of the book cover Radiometric Visual Computing and Visual Content Synthesis. These parts focus on the fundamental techniques for processing information arising from the interaction of light with objects around us, as well as the fundamentals of creating virtual computer generated worlds that mimic all the processing presented in the prior sections. The book is written for a 16 week long semester course and can be used for both undergraduate and graduate teaching, as well as a reference for professionals.

The chapters in this contributed volume showcase current theoretical approaches in the modeling of ocular fluid dynamics in health and disease. By including chapters written by experts from a variety of fields, this volume will help foster a genuinely collaborative spirit between clinical and research scientists. It vividly illustrates the advantages of clinical and experimental methods, data-driven modeling, and physically-based modeling, while also detailing the limitations of each approach. Blood, aqueous humor, vitreous humor, tear film, and cerebrospinal fluid each have a section dedicated to their anatomy and physiology, pathological conditions, imaging techniques, and mathematical modeling. Because each fluid receives a thorough analysis from experts in their respective fields, this volume stands out among the existing ophthalmology literature. Ocular Fluid Dynamics is ideal for current and future graduate students in applied mathematics and ophthalmology who wish to explore the field by investigating open questions, experimental technologies, and mathematical models. It will also be a valuable resource for researchers in mathematics, engineering, physics, computer science, chemistry, ophthalmology, and more.