The first textbook of its kind dealing with composite tissue allograft and allograft transplantation, provides an excellent overview on the subject. It provides a clear description of the current status of the transplant of every composite tissue allograft already performed and others which are still at the basic experimental level.The editors of the book, who also contribute chapters in their expertise, are world renowned surgeons. This book opens with an introductory chapter on the history of this type of transplantation and then details the clinical experience in each graft such as hand, larynx, face, uterus and the related histopathology, immunosuppression and immunomodulation.A multidisciplinary and comprehensive presentation of the various aspects of this new area of transplantation will allow the reader to understand the complexity and the challenges of composite tissue transplantation. A number of important topics are analyzed and discussed in detail, such as the ethical, medicolegal, psychological and immunological implications. New rehabilitation techniques and strategies, together with innovative tools for the functional evaluation of the transplanted parts, are highlighted. A section on the experimental work underlines what lies ahead of us./a

This brilliant synthesis summarizes all of the recent accomplishments – as well as the ongoing research – in the field of composite tissue transplantation. It includes sections on hand transplantation and vascularized bone marrow transplantation. The volume focuses on immunology and the biotechnology/bioengineering aspects of transplantation surgery, as those two areas have demonstrated the most growth within the last five years in terms of current research.

Offering authoritative guidance and a multitude of high-quality images, Facial Trauma Surgery: From Primary Repair to Reconstruction is the first comprehensive textbook of its kind on treating primary facial trauma and delayed reconstruction of both the soft tissues and craniofacial bony skeleton. This unique volume is a practical, complete reference for clinical presentation, fracture pattern, classification, and management of patients with traumatic facial injury, helping you provide the best possible outcomes for patients' successful reintegration into work and society. - Explains the basic principles and concepts of primary traumatic facial injury repair and secondary facial reconstruction. - Offers expert, up-to-date guidance from global leaders in plastic and reconstructive surgery, otolaryngology and facial plastic surgery, oral maxillofacial surgery, neurosurgery, and oculoplastic surgery. - Covers innovative topics such as virtual surgical planning, 3D printing, intraoperative surgical navigation, post-traumatic injury, treatment of facial pain, and the roles of microsurgery and facial transplantation in the treatment facial traumatic injuries. - Includes an end commentary in every chapter provided by Dr. Paul Manson, former Chief of Plastic Surgery at Johns Hopkins Hospital and a pioneer in the field of acute treatment of traumatic facial injuries. - Offers videos that clarify surgical technique, including intraoperative guidance and imaging; transconjunctival approach to the orbit and reconstruction of a zygomaticomaxillary complex fracture; calvarial bone autograft splitting; dental splinting; a systematic method for reading a craniofacial CT scan; and more. - Features superb photographs and illustrations throughout, as well as evidence-based summaries in current areas of controversy. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This text provides an excellent overview on composite tissue allograft and allograft transplantation. A clear description of the current status of the transplant of every compsite tissue allograft already performed and others which are still at the basic expierimental level.

With detailed, expert guidance on each essential topic, Plastic Surgery: Principles and Practice offers single-volume convenience without sacrificing complete coverage of this multi-faceted field. Written by global leading authorities, it provides concise, easy-to-follow instruction with the clinical details and supportive data needed to achieve optimal patient outcomes. Offers thorough coverage of facelift procedures, rhinoplasty, otoplasty and more, along with clinical pearls from masters in the field. Features hundreds of high-quality images including anatomical line art, case photos, and procedural operative photos. I Includes a superb selection of procedural videos of global experts performing key techniques within operating room and close-up clinical pearls. An ideal resource for residents, fellows, and practitioners in plastic surgery, as well as those in otolaryngology, vascular surgery, and cosmetic dermatology.

It is like a fairy story! Or at least a beautiful epic, a truly significant page in the history of medicine, a staggering scene in which several actors come into play, both fundamentalists and clinical practitioners, eager to place all these new developments at the disposal of those suffering from ill health. Everyone is passionate about their work, be it providing new knowledge or perfecting new therapeutic methods. Man has always been fascinated by the possibility of replacing a damaged organ with a healthy one. Several attempts have been made over the centuries, and some miracles have been reported, such as those of Saint Damien and Saint Come as illustrated by Fra Angelico. The modern saga, however, started more modestly on the mouse. It is on the mouse that the first tissue group was discovered; yet the study of human tissue groups could only be carried out on a human. One human must be subjected to the thousands of tests that have enabled us to unravel the extraordinary complexity of the HLA system.

Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine. Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included. The book is written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and those seeking advanced information on adipose stem cells. - Coverage of basic adipose stem cell developmental biology (maturation process during embryogenesis) and mechanisms of regulating self-renewal and activation in the stem cell niche - Includes important methods for isolation and characterizing ASCs, as well as known data any impact of human demographics (age, sex, BMI) on ASC phenotype - An entire section dedicated to ASC biology, additional sections will be devoted to ASCs for stem cell therapy and regenerative medicine, as well as ASCs in tissue engineering applications

A nasal reconstruction authority shows you how to obtain the best outcomes and repair unsatisfactory results from former surgeries. In addition to presenting the latest principles and techniques, this new resource also examines evolving concepts and methods, keeping you at the forefront of today's practice. The book emphasizes the restoration of nasal defects-from simple to complex-and achieving normal appearance and function. Comprehensive coverage of all nasal injuries and available surgical methods-both cutting edge as well as older, established approaches-help you choose the best approach for each patient and situation. Full-color clinical photos offer real-life clinical views of conditions and step-by-step surgical results, and a bonus DVD-featuring operative clips-shows techniques in action as well as providing hints and tips for obtaining optimal surgical outcomes. Offers detailed coverage of the principles of nasal reconstruction and application of the aesthetic principles as they apply to the whole face. Discusses design, planning, technique, and pitfalls to avoid for the full range of nasal reconstruction for complete surgical management guidance. Covers the latest topics in reconstruction including three-stage forehead flap . repair of the cocaine nose . advances in the use of free flaps for lining . forehead skin graft . microvascular reconstruction of the nose and face . and revision surgery to equip you to meet a wide range of surgical needs. Features guidance on reconstruction of nasal defects due to cancer, trauma, infection, congential deformity, drug abuse, and collagen vascular disease. Provides expert advice on revision surgery-as well as refinement/touch-up procedures-to effectively handle a previously repaired nose. Includes a DVD with 90 minutes of surgical footage-including cases with a complete 2 stage and a 3 stage folded forehead flap-as well as hints and tips for obtaining optimal surgical outcomes.

Get a quick, expert overview of optimal therapeutic interventions for pediatric patients with musculoskeletal conditions of the hand. This concise resource by Drs. Joshua Abzug, Scott Kozin, and Rebecca Neiduski offers practical recommendations and guidelines along with key background information, for a well-rounded, concise perspective on hand therapy for children. You'll benefit from the knowledge and experience of orthopaedic surgeons and other members of the rehabilitation care team who provide a real-world, multidisciplinary approach to this complex field. - Covers a range of musculoskeletal conditions, including: congenital disorders, joint disorders, neuromuscular disorders, sports-related injuries, and trauma. - Includes supporting background information, including an overview of embryology, intrauterine diagnosis, and physical functional development. - Covers complementary, practical, and clinical approaches, including orthotic intervention and prosthetics. - Editors and contributors represent orthopaedic surgeons and members of the rehabilitation care team for a well-rounded perspective.

Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results. - Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration - Explains the importance and future potential of regenerative medicine to the transplant community - Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions