This book collects the publications of Shinya lnoué, pioneering cell biophysicist and winner of the 2003 International Prize for Biology. The articles cover the discovery, and elucidate the behavior in living cells, of the dynamic molecular filaments which organize the cell and play a central role in cell division. Other articles report on the development of microscopes, especially those using polarized light and digital image enhancement, which make possible studies of the ever-changing molecular architecture directly in living cells. This book also contains many high quality photo-micrographs as well as an appended DVD with an extensive collection of video movies of active living cells. After training in Tokyo and at Princeton University, Dr Inoué has held teaching positions at the University of Washington, Tokyo Metropolitan University, University of Rochester, Dartmouth Medical School, and University of Pennsylvania. He is a member of the U.S. National Academy of Sciences and currently holds the title of Distinguished Scientist at the Marine Biological Laboratory in Woods Hole, Massachusetts.

This volume of the acclaimed Methods in Cell Biology series provides specific examples of applications of confocal microscopy to cell biological problems. It is an essential guide for students and scientists in cell biology, neuroscience, and many other areas of biological and biomedical research, as well as research directors and technical staff of microscopy and imaging facilities. An integrated and up-to-date coverage on the many various techniques and uses of the confocal microscope (CM). Includes detailed protocols accessible to new users Details how to set up and run a "Confocal Microscope Core Facility" Contains over 170 figures

Minimally Invasive Surgical Oncology is aimed at the minimal invasive surgeon as well as at the general surgeon and surgical trainee who wish to explore this field. It covers disciplines like gastroenterology, gynecology, urology, thoracic and pediatrics and builds bridges to oncologists and internal medicine. It gives a state-of-the art overview and perspectives for future developments and research as well. The book serves as an operative guide for a new generation of surgeons and offers the extraordinary feature being a text book, an operative atlas and a quick reference guide as well. The reader is provided with a tool in hand which synthesizes the latest knowledge in traditional therapies like chemotherapies and gives a comprehensive overview how to proceed in treating a cancer patient using minimal access techniques.

Ever since television became practical in the early 1950s, closed-circuit television (CCTV) in conjunction with the light microscope has provided large screen display, raised image contrast, and made the images formed by ultraviolet and infrared rays visible. With the introduction of large-scale integrated circuits in the last decade, TV equipment has improved by leaps and bounds, as has its application in microscopy. With modem CCTV, sometimes with the help of digital computers, we can distill the image from a scene that appears to be nothing but noise; capture fluorescence too dim to be seen; visualize structures far below the limit of resolution; crispen images hidden in fog; measure, count, and sort objects; and record in time-lapsed and high-speed sequences through the light microscope without great difficulty. In fact, video is becoming indispensable for harnessing the fullest capacity of the light microscope, a capacity that itself is much greater than could have been envisioned just a few years ago. The time seemed ripe then to review the basics of video, and of microscopy, and to examine how the two could best be combined to accomplish these tasks. The Marine Biological Laboratory short courses on Analytical and Quantitative Light Microscopy in Biology, Medicine, and the Materials Sciences, and the many inquiries I received on video microscopy, supported such an effort, and Kirk Jensen of Plenum Press persuaded me of its worth.

"In the worldwide circulation of the products of cultural industries, an important role is played by Japanese popular culture in European contexts. Marco Pellitteri shows that the contact between Japanese pop culture and European youth publics occurred during two phases. By use of metaphor, the author calls them the Dragon and the Dazzle. The first took place between 1975 and 1995, the second from 1996 to today. They can be distinguished by the modalities of circulation and consumption/re-elaboration of Japanese themes and products in the most receptive countries: Italy, France, Spain, Germany and, across the ocean, the United States. During these two phases, several themes have been perceived, in Europe, as rising from Japan's social and mediatic systems. Among them, this book examines the most apparent from a European point of view: the author names them machine, infant, and mutation, visible mostly through manga, anime, videogames, and toys. Together with France, Italy is the European country that in this respect has had the most central role. There, Japanese imagination has been acknowledged not only by young people, but also by politicians, television programmers, the general public, educators, comics and cartoons authors. The growing influence of Japanese pop culture, connected to the appreciation of its manga, anime, toys, and videogames, also urges political and mediologic questions linked to the identity/ies of Japan as they are understood--wrongly or rightly--in Europe and the West, and to the increasingly important role of Japan in international relations."--Back cover

This book discusses critical areas of progress in stem cell research, including the most recent research and applications of pluripotent embryonic cells, induced pluripotent cells, oligopotent tissue stem cells and cancer stem cells. The text covers basic knowledge of stem cell biology, stem cell ethics, development of techniques for applying stem cell therapy, the technology of obtaining appropriate cells for transplantation as well as the role of stem cells in cancer and how therapy may be directed to cancer stem cells. This new volume is essential reading for all scientists currently in the field or allied research areas, and those for those graduate students who envision a career in stem cells.

This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.

Perform Accurate, Cost-Effective Product Testing Nondestructive testing has become the leading product testing standard, and Handbook of Non-Destructive Evaluations by Chuck Hellier is the unparalleled one-stop, A-to-Z guide to this subject. Covering the background, benefits, limitations, and applications of each, this decision-simplifying resource looks at both the major and emerging nondestructive evaluation methods, including: visual testing...penetrant testing...magnetic particle testing...radiographic testing...Ultrasonic testing... eddy current testing...thermal infrared testing...and acoustic emission testing. In clear, understandable terms, the Handbook shows you how to interpret results and formulate the right decisions based on them, making it a welcome resource for engineers, metallurgists, quality control specialists, and anyone else involved in product design, manufacture, or maintenance. The Handbook is also the ideal prep tool if you’re seeking certification in AWS/CSWIP, ASNT Level III, ACCP, and IRRSP programs. If you’re looking for a one-stop answer to all your nondestructive testing questions, your search ends here.

Written by leading optical phase microscopy experts, this book is a comprehensive reference to phase microscopy and nanoscopy techniques for biomedical applications, including differential interference contrast (DIC) microscopy, phase contrast microscopy, digital holographic microscopy, optical coherence tomography, tomographic phase microscopy, spectral-domain phase detection, and nanoparticle usage for phase nanoscopy The Editors show biomedical and optical engineers how to use phase microscopy for visualizing unstained specimens, and support the theoretical coverage with applied content and examples on designing systems and interpreting results in bio- and nanoscience applications. Provides a comprehensive overview of the principles and techniques of optical phase microscopy and nanoscopy with biomedical applications. Tips/advice on building systems and working with advanced imaging biomedical techniques, including interpretation of phase images, and techniques for quantitative analysis based on phase microscopy. Interdisciplinary approach that combines optical engineering, nanotechnology, biology and medical aspects of this topic. Each chapter includes practical implementations and worked examples.

How teachers view the nature of scientific knowledge is crucial to their understanding of science content and how it can be taught. This book presents an overview of the dynamics of scientific progress and its relationship to the history and philosophy of science, and then explores their methodological and educational implications and develops innovative strategies based on actual classroom practice for teaching topics such the nature of science, conceptual change, constructivism, qualitative-quantitative research, and the role of controversies, presuppositions, speculations, hypotheses, and predictions. Field-tested in science education courses, this book is designed to involve readers in critically thinking about the history and philosophy of science and to engage science educators in learning how to progressively introduce various aspects of ‘science-in-the-making’ in their classrooms, to promote discussions highlighting controversial historical episodes included in the science curriculum, and to expose their students to the controversies and encourage them to support, defend or critique the different interpretations. Innovating Science Teacher Education offers guidelines to go beyond traditional textbooks, curricula, and teaching methods and innovate with respect to science teacher education and classroom teaching.