Collaborative Innovation In Drug Discovery
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Author |
: Rathnam Chaguturu |
Publisher |
: John Wiley & Sons |
Total Pages |
: 768 |
Release |
: 2014-04-14 |
ISBN-10 |
: 9780470917374 |
ISBN-13 |
: 0470917377 |
Rating |
: 4/5 (74 Downloads) |
Synopsis Collaborative Innovation in Drug Discovery by : Rathnam Chaguturu
Can academia save the pharmaceutical industry? The pharmaceutical industry is at a crossroads. The urgent need for novel therapies cannot stem the skyrocketing costs and plummeting productivity plaguing R&D, and many key products are facing patent expiration. Dr. Rathnam Chaguturu presents a case for collaboration between the pharmaceutical industry and academia that could reverse the industry's decline. Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships provides insight into the potential synergy of basing R&D in academia while leaving drug companies to turn hits into marketable products. As Founder and CEO of iDDPartners, focused on pharmaceutical innovation, Founding president of the International Chemical Biology Society, and Senior Director-Discovery Sciences, SRI International, Dr. Chaguturu has assembled a panel of experts from around the world to weigh in on issues that affect the two driving forces in medical advancement. Gain global perspectives on the benefits and potential issues surrounding collaborative innovation Discover how industries can come together to prevent another "Pharma Cliff" Learn how nonprofits are becoming the driving force behind innovation Read case studies of specific academia-pharma partnerships for real-life examples of successful collaboration Explore government initiatives that help foster cooperation between industry and academia Dr. Chaguturu’s thirty-five years of experience in academia and industry, managing new lead discovery projects and forging collaborative partnerships with academia, disease foundations, nonprofits, and government agencies lend him an informative perspective into the issues facing pharmaceutical progress. In Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships, he and his expert team provide insight into the various nuances of the debate.
Author |
: Rathnam Chaguturu |
Publisher |
: John Wiley & Sons |
Total Pages |
: 768 |
Release |
: 2014-03-28 |
ISBN-10 |
: 9781118778128 |
ISBN-13 |
: 111877812X |
Rating |
: 4/5 (28 Downloads) |
Synopsis Collaborative Innovation in Drug Discovery by : Rathnam Chaguturu
Can academia save the pharmaceutical industry? The pharmaceutical industry is at a crossroads. The urgent need for novel therapies cannot stem the skyrocketing costs and plummeting productivity plaguing R&D, and many key products are facing patent expiration. Dr. Rathnam Chaguturu presents a case for collaboration between the pharmaceutical industry and academia that could reverse the industry's decline. Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships provides insight into the potential synergy of basing R&D in academia while leaving drug companies to turn hits into marketable products. As Founder and CEO of iDDPartners, focused on pharmaceutical innovation, Founding president of the International Chemical Biology Society, and Senior Director-Discovery Sciences, SRI International, Dr. Chaguturu has assembled a panel of experts from around the world to weigh in on issues that affect the two driving forces in medical advancement. Gain global perspectives on the benefits and potential issues surrounding collaborative innovation Discover how industries can come together to prevent another "Pharma Cliff" Learn how nonprofits are becoming the driving force behind innovation Read case studies of specific academia-pharma partnerships for real-life examples of successful collaboration Explore government initiatives that help foster cooperation between industry and academia Dr. Chaguturu’s thirty-five years of experience in academia and industry, managing new lead discovery projects and forging collaborative partnerships with academia, disease foundations, nonprofits, and government agencies lend him an informative perspective into the issues facing pharmaceutical progress. In Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships, he and his expert team provide insight into the various nuances of the debate.
Author |
: Bhushan Patwardhan |
Publisher |
: Academic Press |
Total Pages |
: 482 |
Release |
: 2016-10-03 |
ISBN-10 |
: 9780128018224 |
ISBN-13 |
: 0128018224 |
Rating |
: 4/5 (24 Downloads) |
Synopsis Innovative Approaches in Drug Discovery by : Bhushan Patwardhan
Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. - Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned - Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines - Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery
Author |
: National Academies of Sciences, Engineering, and Medicine |
Publisher |
: National Academies Press |
Total Pages |
: 103 |
Release |
: 2020-01-27 |
ISBN-10 |
: 9780309498517 |
ISBN-13 |
: 0309498511 |
Rating |
: 4/5 (17 Downloads) |
Synopsis The Role of NIH in Drug Development Innovation and Its Impact on Patient Access by : National Academies of Sciences, Engineering, and Medicine
To explore the role of the National Institutes of Health (NIH) in innovative drug development and its impact on patient access, the Board on Health Care Services and the Board on Health Sciences Policy of the National Academies jointly hosted a public workshop on July 24â€"25, 2019, in Washington, DC. Workshop speakers and participants discussed the ways in which federal investments in biomedical research are translated into innovative therapies and considered approaches to ensure that the public has affordable access to the resulting new drugs. This publication summarizes the presentations and discussions from the workshop.
Author |
: Institute of Medicine |
Publisher |
: National Academies Press |
Total Pages |
: 107 |
Release |
: 2014-02-06 |
ISBN-10 |
: 9780309292498 |
ISBN-13 |
: 0309292492 |
Rating |
: 4/5 (98 Downloads) |
Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Author |
: Bin Yu |
Publisher |
: Elsevier |
Total Pages |
: 988 |
Release |
: 2023-07-19 |
ISBN-10 |
: 9780443186127 |
ISBN-13 |
: 044318612X |
Rating |
: 4/5 (27 Downloads) |
Synopsis Privileged Scaffolds in Drug Discovery by : Bin Yu
Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited epserts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years. Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable. - Provides wide coverage of privileged scaffolds in new drug discovery - Includes complex and diverse natural product scaffolds - Covers applications to peptides and peptide-based drugs
Author |
: Al-Sartawi, Abdalmuttaleb M.A. Musleh |
Publisher |
: IGI Global |
Total Pages |
: 371 |
Release |
: 2019-08-30 |
ISBN-10 |
: 9781799800644 |
ISBN-13 |
: 1799800644 |
Rating |
: 4/5 (44 Downloads) |
Synopsis Global Approaches to Sustainability Through Learning and Education by : Al-Sartawi, Abdalmuttaleb M.A. Musleh
Unequal distribution of wealth, poverty, pollution, and gender inequality are just a few of the problems we face and struggle to eliminate. Sustainable development offers a long-term holistic solution to these problems through meeting the needs of the current generation without endangering the capability of future generations in meeting their own needs. Sustainable education or education for sustainability is a transformative learning paradigm that prepares learners and provides them with knowledge, ethical awareness, skills, values, and attitudes to achieve sustainable goals. Global Approaches to Sustainability Through Learning and Education is a comprehensive academic publication that facilitates a greater understanding of sustainable development and fosters a culture of sustainability through learning and education. Highlighting a range of topics such as ethics, game-based learning, and knowledge management, this book is ideal for teachers, environmentalists, higher education faculty, activists, curriculum developers, academicians, researchers, professionals, administrators, and policymakers.
Author |
: Helen Yu |
Publisher |
: Edward Elgar Publishing |
Total Pages |
: 281 |
Release |
: 2016-11-25 |
ISBN-10 |
: 9781785369377 |
ISBN-13 |
: 1785369377 |
Rating |
: 4/5 (77 Downloads) |
Synopsis Achieving Proof of Concept in Drug Discovery and Development by : Helen Yu
One of the major shortcomings of the current drug discovery and development process is the inability to bridge the gap between early stage discoveries and pre-clinical research in order to advance innovations beyond the discovery phase. This book examines a drug discovery and development model, where the respective expertise of academia and industry are brought together to take promising discoveries through to proof of concept, providing a means to de-risk the drug discovery and development process.
Author |
: Ibis Sanchez Serrano |
Publisher |
: Academic Press |
Total Pages |
: 174 |
Release |
: 2019-06-05 |
ISBN-10 |
: 9780128142936 |
ISBN-13 |
: 0128142936 |
Rating |
: 4/5 (36 Downloads) |
Synopsis The Core Model by : Ibis Sanchez Serrano
The Core Model: A Collaborative Paradigm for the Pharmaceutical Industry and Global Health Care develops the innovative core model, an organizational research and design paradigm and economic theory that proposes a collaborative approach to resolving global health issues and improving the productivity of drug development. The model proposes that scientific collaboration does not occur in an unstructured manner, but actually takes place within a highly structured order where knowledge is transferred, integrated and finally translated into commercial products. An understanding of this model will help solve the global pharmaceutical industry ́s productivity problems and address important global health care and economic issues. This book is useful to researchers, advanced students, regulators, and management in pharmaceutical industries, as well as healthcare professionals, those working in health economics, and those interested in scientific innovation processes.
Author |
: Institute of Medicine |
Publisher |
: National Academies Press |
Total Pages |
: 118 |
Release |
: 2012-04-04 |
ISBN-10 |
: 9780309222174 |
ISBN-13 |
: 0309222176 |
Rating |
: 4/5 (74 Downloads) |
Synopsis Strengthening a Workforce for Innovative Regulatory Science in Therapeutics Development by : Institute of Medicine
The development and application of regulatory science - which FDA has defined as the science of developing new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA-regulated products - calls for a well-trained, scientifically engaged, and motivated workforce. FDA faces challenges in retaining regulatory scientists and providing them with opportunities for professional development. In the private sector, advancement of innovative regulatory science in drug development has not always been clearly defined, well coordinated, or connected to the needs of the agency. As a follow-up to a 2010 workshop, the IOM held a workshop on September 20-21, 2011, to provide a format for establishing a specific agenda to implement the vision and principles relating to a regulatory science workforce and disciplinary infrastructure as discussed in the 2010 workshop.