"When a Midwest, working family's daughter is tragically murdered by a prankster's cocaine spike in her drink, the father and mother find a way to turn the tables against the entire drug world. Not to kill anyone, but to put the drug dealers and cartels out of business. Take away the cocaine addiction, the same way the South America tribe leaders do for their members with a native plant,and the entire problem goes away. In America's case, no customers, no money and no market. The world sees it first as a terrorist tragedy, but then sees it as the solution to the world's devastating drug scourge." Arlen Booth, Author

Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.

Here is today's most in-depth reference for any cardiologist, internist, or nephrologist interested in hypertension. Drawing from international experience in cardiology, physiology, and nephrology, Drs. Lip and Hall have assembled a group of section editors and contributors second to none. You'll find the long-term effects of primary and secondary hypertension and a lengthy section on hypertensions for special populations featured prominently. Prevention and treatment of hypertension are covered in detail, from lifestyle and diet issues to drug choice and delivery, and the section on comparison of guidelines is unique to this book. Find comprehensive coverage of hypertension including pathogenesis, prevention, and treatment all in one practical volume. See the complete systemic problems of hypertension at a glance with detailed, full-color illustrations of cellular and clinical manifestations. Simplify navigating the complexities of hypertension using algorithms for clinical exam and diagnosis. Get specific insight into prevention and treatment of hypertension in special populations. Go global with a comprehensive section on worldwide guidelines and the application of clinical material to local standards of practice.

Animal and Translational Models for CNS Drug Discovery combines the experience of academic, clinical and pharmaceutical neuroscientists in a unique collaborative approach to provide a greater understanding of the relevance of animal models of neuropsychiatric disorders and their role as translational tools for the discovery of CNS drugs being developed for the treatment of these disorders. The focus of this three-volume series of essays is to present a consensual picture of the translational value of animal models from leading experts actively involved in the use of animal models for understanding fundamental neurobiology of CNS disorders and the application of this knowledge to CNS drug discovery, and clinical investigators involved in clinical trials, drug development and eventual registration of novel pharmaceuticals. Each volume of the Animal and Translational Models for CNS Drug Discovery series is dedicated to the development and use of animal models in key therapeutic areas in psychiatric, neurologic and reward deficit disorders. Each volume has introductory chapters expressing the view of the role and relevance of animal models for CNS drug discovery and development from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in relevant therapeutic areas and discusses the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. - Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process - Critical evaluation of animal and translational models improving transition from drug discovery and clinical development - Emphasizes what results mean to the overall drug discovery process - Explores issues in clinical trial design and conductance in each therapeutic area - Each volume is available for purchase individually.

The Code of Federal Regulations is the codification of the general and permanent rules published in the Federal Register by the executive departments and agencies of the Federal Government.

In the tradition of The Wire, the harrowing story of the cinematic transformation of Miami, one of America’s most bustling cities—rife with a drug epidemic, a burgeoning refugee crisis, and police brutality—from journalist and award-winning author Nicholas Griffin Miami, Florida, famed for its blue skies and sandy beaches, is one of the world’s most popular vacation destinations, with nearly twenty-three million tourists visiting annually. But few people have any idea how this unofficial capital of Latin America came to be. The Year of Dangerous Days is a fascinating chronicle of a pivotal but forgotten year in American history. With a cast that includes iconic characters such as Jimmy Carter, Fidel Castro, and Janet Reno, this slice of history is brought to life through intertwining personal stories. At the core, there’s Edna Buchanan, a reporter for the Miami Herald who breaks the story on the wrongful murder of a black man and the shocking police cover-up; Captain Marshall Frank, the hardboiled homicide detective tasked with investigating the murder; and Mayor Maurice Ferré, the charismatic politician who watches the case, and the city, fall apart. On a roller coaster of national politics and international diplomacy, these three figures cross paths as their city explodes in one of the worst race riots in American history as more than 120,000 Cuban refugees land south of Miami, and as drug cartels flood the city with cocaine and infiltrate all levels of law enforcement. In a battle of wills, Buchanan has to keep up with the 150 percent murder rate increase; Captain Frank has to scrub and rebuild his homicide bureau; and Mayor Ferré must find a way to reconstruct his smoldering city. Against all odds, they persevere, and a stronger, more vibrant Miami begins to emerge. But the foundation of this new Miami—partially built on corruption and drug money—will have severe ramifications for the rest of the country. Deeply researched and covering many timely issues including police brutality, immigration, and the drug crisis, The Year of Dangerous Days is both a clarion call and a re-creation story of one of America’s most iconic cities.