This issue of Critical Care Clinics, guest edited by Drs. Hernando Gomez Danies and Joseph Carcillo, focuses on Coagulation/Endothelial Dysfunction. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Cell-cell communication breakdown and endothelial dysfunction; Role of the Tie2/Angiopoetin pathway in endothelial dysfunction; The Glycocalyx; Platelet activation and endothelial dysfunction; Role of antithrombin III and tissue factor pathway; Red blood cell dysfunction; Microvascular hemodynamics, autoregulation and mechanotransduction control of blood flow distribution; Nitric oxide and endothelial dysfunction; Microvascular dysfunction; Hemolytic Uremic Syndrome and atypical HUS; Thrombotic thrombocytopenic purpura, Heparin induced thrombocytopenia and Disseminated intravascular coagulation in the critically ill; Thrombocytopenia associated multiple organ failure (TAMOF); Meningococcemia; Immune consequences of endothelial dysfunction during sepsis; Therapeutic targets in thrombotic microangiopathies with a focus on endothelial disorders; and Coagulation disorders in HLH/Macrophage activation syndrome.

This issue of Critical Care Clinics, edited by Mervyn singer and Manu Shankar-Hari, includes: Sepsis 3.0 Definitions; Epidemiology and Outcomes; Pathophysiology of sepsis; Pathophysiology of Septic shock; Mechanism of organ dysfunction in sepsis; Endocrine and metabolic alterations in sepsis: challenges and treatments; The immune system in sepsis; Nutrition and Sepsis; Common sense approach to managing sepsis; Biomarkers for sepsis and their use; Personalizing sepsis care; Novel interventions - What’s new and the future; and Long term outcomes following Sepsis.

This issue of Critical Care Clinics, edited by Dr. Kianoush Kashani in collaboration with Consulting Editor Dr. John Kellum, is focused on Intensive Care Unit Telemedicine. Topics in this issue include: ICU telemedicine program administration: from start to full implementation; ICU telemedicine multidisciplinary care teams; ICU telemedicine technology; Impact of ICU telemedicine on outcomes; Quality assurance of ICU telemedicine; ICU telemedicine cost-effectiveness and financial analyses; ICU telemedicine care models; ICU telemedicine in the era of big data, artificial intelligence, and computer clinical decision support systems; ICU Telemedicine: Innovations and Limitations; ICU telemedicine: provider-patient satisfaction; and ICU telemedicine services beyond medical management: Tele-pharmacy, tele-procedure, tele-dialysis, tele-stroke: evidence, benefits, risks, and legal ramifications.

This issue of Critical Care Clinics, guest edited by Drs. Geno Merli, Bharat Awsare, and Michael Baram, focuses on Pulmonary Embolism in the ICU. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Making the Diagnosis of Pulmonary Embolism: Stable Versus Unstable; Risk Stratification; Overview of Management of Sub-massive and Massive Pulmonary Embolism; Standard Therapy: Systemic Thrombolytics; IR Therapy: IVC Filter and Catheter-based Therapies; Surgical Therapy: Embolectomy; Supportive Therapy: Management of Acute RV Failure; Supportive Therapy: ECMO/RVAD; Special Considerations; Therapy in Sub-populations; and Post-ICU Follow-up.

Guest edited by Dr. Michell Levy, articles for this edition of Critical Care Clinics include: Specificity and sensitivity; How to use biomarkers;Physiologic Parameters as biomarkers: What can we learn from physiologic variables and variation?;Multi-marker Panels;Coagulation biomarkers;Biomarkers in neurosurgery;Biomarkers in Trauma; and Cardiac Biomarkers

This issue of Critical Care Clinics, guest edited by Dr. Mitchell M. Levy, focuses on Biomarkers in Critical Care. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: The History of Biomarkers; Biomarkers for Identifying Infection; Procalcitonin: Where Are We Now?; Soluble TREM-1: Diagnosis or Prognosis?; Lubricin as a Biomarker in Sepsis; Check Point Inhibitors and Their Role in Immunosuppression in Sepsis; Metabolomics and the Microbiome as Biomarkers in Sepsis; Lactate: Where Are We Now?; Predicting Renal Dysfunction; Biomarkers in the Evolution of ARDS; Biomarkers and RV Dysfunction; Biomarkers and Precision Medicine: State of the Art; The Use of Biomarkers for Population Homogeneity in Clinical Trials; and The Future of Biomarkers.

This issue of Critical Care Clinics, guest edited by Drs. Marie Baldisseri, Mary Reed, and Randy Wax, in collaboration with Consulting Editor John Kellum, is devoted to Intensive Care Unit in Disaster. Topics in this issue include: Intensive care role in disaster management; Preparing the ICU for disaster; Augmenting capacity; Triage; Natural disasters; Biological/pandemic disasters; Chemical disasters; Radiation; Anthropogenic (terrorist/criminal act) disasters; Special populations (i.e., chronically ill, morbidly obese, pregnant); Pediatrics; Austere environments; Hospital as disaster Ground Zero; and Special considerations (i.e., mental health, ethics, public relations).

Dr. John Kellum has assembled an essential update on the topic of Nephrology as it relates to Critical Care Medicine. Articles include: Diagnostic criteria, Biomarkers for AKI, Sepsis-induced AKI,Drug-induced AKI, Cardio-renal syndrome,Surgery Associated AKI,Contrast-induced AKI, Principles of Fluid Therapy,Fluid composition and clinical effects, Renal replacement therapy, and Understanding acid-base.

This issue of Critical Care Clinics focuses on two crucial topics: Enhanced Recovery in the ICU After Cardiac Surgery (guest edited by Dr. Daniel Engelman) and New Developments in Cardiopulmonary Resuscitation (guest edited by Dr. Clifton Callaway).

This issue of Critical Care Clinics edited by Dr. Margaret Parker on Pediatric Critical Care features topics such as:1. Acute Respiratory Failure, Post-op Cardiac Surgery, Septic Shock, Acute Renal Failure, Traumatic Brain Injury, Encephalitis, Status Asthmaticus, Status Epilepticus, Bleeding/coagulopathy, and Transfusion.