Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Topics discussed include the omics landscape of impaired mitochondrial bioenergetics, hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth. Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others. - Provides a thorough discussion of foundational aspects of bioenergetics and disease, modes of analysis, and treatments for impaired bioenergetics - Discusses the role of bioenergetics and treatment pathways in brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among other diseases and disorders - Features chapter contributions from international leaders in translational bioenergetics research and clinical practice

Extensively revised, the fourth edition of this highly successful book takes into account the many newly determined protein structures that provide molecular insight into chemiosmotic energy transduction, as well as reviewing the explosive advances in 'mitochondrial physiology'-the role of the mitochondria in the life and death of the cell. Covering mitochondria, bacteria and chloroplasts, the fourth edition of Bioenergetics provides a clear and comprehensive account of the chemiosmotic theory and its many applications. The figures have been carefully designed to be memorable and to convey the key functional and mechanistic information. Written for students and researchers alike, Bioenergetics is the most well-known, current and respected text on chemiosmotic theory and membrane bioenergetics available. - BMA Medical Book Awards 2014-Highly Commended, Basic and Clinical Sciences,2014,British Medical Association - Chapters are now divided between three interlocking sections: basic principles, structures and mechanisms, and mitochondrial physiology - Covers new advances in the structure and mechanism of key bioenergetic proteins, including complex I of the respiratory chain and transport proteins - Details cellular bioenergetics, mitochondrial cell biology and signal transduction, and the roles of mitochondria in physiology, disease and aging - Offers readers clear, visual representation of structural concepts through full colour figures throughout the book

Principles of Bioenergetics summarizes one of the quickly growing branches of modern biochemistry. Bioenergetics concerns energy transductions occurring in living systems and this book pays special attention to molecular mechanisms of these processes. The main subject of the book is the "energy coupling membrane" which refers to inner membranes of intracellular organelles, for example, mitochondria and chloroplasts. Cellular cytoplasmic membranes where respiratory and photosynthetic energy transducers, as well as ion-transporting ATP-synthases (ATPases) are also part of this membrane. Significant attention is paid to the alternative function of mitochondria as generators of reactive oxygen species (ROS) that mediate programmed death of cells (apoptosis and necrosis) and organisms (phenoptosis). The latter process is considered as a key mechanism of aging which may be suppressed by mitochondria-targeted antioxidants.

"More in-depth than cursory discussions found in exercise physiology texts and more practical and accessible than dedicated bioenergetics texts, Bioenergetics Primer for Exercise Science encompasses all the up-to-date research and information regarding human bioenergetics and energy metabolism. It offers both students and professionals a depth of knowledge that will inform their further study, research, and profession."--Jacket.

Bioenergetics is the study of the way biological systems, usually at the molecular level, utilize and convert energy in order to drive the biochemical reactions that constitute life. However, because of its often quantitative basis and the amount of technical jargon, the subject tends to alienate and intimidate students. This beautifully illustrated text has a lucid and logical approach to the subject. The text uses the modern perspective throughout so that the student is given an easily assimilable, logical introduction to the important concepts of the subject, particulary the core concept, the 'chemiosmotic theory'. It has been specifically designed to make information easily accessible by devoting each double-page spread to one topic. Within the spread, a variety of carefully constructed diagrams present information in a concise and innovative manner. The text is further enhanced by a comprehensive guide to additional reading. Original, easily understood combination of visual and written information. 43 double-page speads give a clear and concise introduction to this traditionally difficult subject. The most up to date text available, covering all modern molecular genetic techniques. Competitively priced.

Revised and updated to include the many developments that have taken place in bioenergetics, this text covers the structures of key membrane proteins involved in bioenergetics and mitochondrial physiology.

1. The Mitochondrial and Bacterial Respiratory Chains: From MacMunn and Keilin to Current Concepts; P. Nicholls. 2. The Mitochondrial Enzymes of Oxidative Phosphorylation; Y. Hatefi. 3. Proton Pumps of Respiratory Chain Enzymes; S. Papa, et al. 4. Uncoupling of Respiration and Phosphorylation; V.P. Skulachev. 5. Crystallization, Structure, and Possible Mechanism of Action of Cytochrome c Oxidase from the Soil Bacterium Paracoccus denitrificans; M. Hartmut, et al. 6. The Structure of Crystalline Bovine Heart Cytochrome c Oxidase; S. Yoshikawa, et al. 7. Electron and Proton Transfer in.

Bioenergetics is the revolutionary new therapy that uses the language of the body to heal the problems of the mind. This exciting body-mind approach to personality has a liberating and positive effect on emotional, physical, and psychic distress. Dr. Alexander Lowen, founder and prime mover of this fast-growing therapy, writes that increased joy and pleasure are possible in every day life through an understanding of how your body functions energetically: how it determines what you feel, think, and do. Dr. Lowen points out that lack of energy is the result of chronic muscular tensions, a condition caused by the suppression of feelings. These tensions can be dissolved through the direct body work in bioenergetic exercise, which restores the potential for living a rich, full life. Dr. Lowen analyzes common physical ailments like headaches and lower back pain and shows how they too can be overcome by releasing the muscular tenstion that create them. Generously illustrated with line drawings of bioenergetic exercises, this book is sure to bring freedom, confidence, and pleasure to thousands of men and women. "In this highly interesting and valuable attempt to restore the body to the mind, Dr. Alexander Lowen sets out in a practically useful way the principles of his new form of psychotherapy. Bioenergetics is destined to become widely influential." —Ashley Montagu

This book summarises current knowledge of the structure, function,biosynthesis and regulation of energy-transducing enzymes inmitochondria, chloroplasts and bacteria. Each of the twenty chapters is written by top experts in their field, and Prof. Ernster has ensured that the book as a whole gives a well-integrated picture of the present state of knowledge of the field at its different levels and complexities. Since the publication of Bioenergetics edited by Lars Ernster in 1984, (New Comprehensive Biochemistry Vol. 9) the whole field of bioenergetics has undergone a tremendous expansion. Additionally a transition from membrane bioenergetics to molecular bioenergetics has accompanied this expansion - due mainly to the spectacular progress in the field of molecular biology over the past twenty years.Hence this volume, Molecular Mechanisms in Bioenergetics, is certain to be of interest, not only to the specialist in bioenergetics, but also to researchers working in the various fields of biophysics, biochemistry, molecular biology, genetics, cell biology and physiology. Also of interest, this volume contains an historical introduction, including a list of earlier publications relating to the history of bioenergetics.