A history of the art of transfusions and a scientific discourse on the chemistry of blood.

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

Historians of the intellectual and literary culture of the Enlightenment have recognised the importance of Andrew Millar (1705-68). His publisher's imprint adorned the title-pages of the most important works of the eighteenth century, in fiction, poetry, drama, medicine, and philosophy. This is the first extended study of Millar's commercial and social role in the commissioning, production, circulation, and consumption of Enlightenment literature in Britain. Providing a new intervention on the culture of Enlightenment this study shows how and why Millar provoked major controversies through his role as friend, patron, and publisher to great rivals in the republic of letters. An unprecedent analysis of publishing and authorship at the intersection of politics, business, visual arts, moral debate, and literary self-fashioning, this study of Andrew Millar also shows the degree to which Scottish identity shaped a professional career within London's rise as the cosmopolitan centre of learning and trade at the heart of the British empire. This volume presents hundreds of previously unpublished letters that passed between Millar and his literary network, and includes the 52 letters that passed between Millar and David Hume, the majority of which have been edited for the first time since 1931. This is a major contribution to the material and intellectual worlds that defined the culture of Enlightenment in Britain during the eighteenth century, casting new light in the history of publishing and authorship.

Established for more than thirty years as one of the world's most widely read gynecology texts, Clinical Gynecologic Endocrinology and Infertility is now in its Eighth Edition. In a clear, user-friendly style enhanced by abundant illustrations, algorithms, and tables, the book provides a complete explanation of the female endocrine system and its disorders and offers practical guidance on evaluation and treatment of female endocrine problems and infertility. Major sections cover reproductive physiology, clinical endocrinology, contraception and infertility. This edition has a modern full-color design. A companion website includes the fully searchable text, image bank and links to PubMed references.