Proceedings of the NATO Advanced Study Institute, Hannover, Germany, July 13-25, 1979

For nearly 30 years, Dr. Meir Kryger’s must-have guide to sleep medicine has been the gold standard in this fast-changing field. This essential, full-color reference includes more than 20 unique sections and over 170 chapters covering every aspect of sleep disorders, giving you the authoritative guidance you need to offer your patients the best possible care. Evidence-based content helps you make the most well-informed clinical decisions. An ideal resource for preparing for the sleep medicine fellowship examination. New content on sleep apnea, neurological disorders, legal aspects of sleep medicine, dental sleep medicine genetics, circadian disorders, geriatrics, women’s health, cardiovascular diseases, and occupational sleep medicine, keeps you fully up to date. Updates to scientific discoveries and clinical approaches ensure that you remain current with new knowledge that is advancing the diagnosis and management of sleep disorders.

This volume is the first bibliography to be published on the broad subject of cycles in humans and nature. The importance of cycles as a model for understanding the world is as old as the Bible and other ancient records of past civilizations. The modern investigation of diverse fields of study has resulted in the concept of cycles once again gaining center stage as an interdisciplinary model for reaching a better understanding of the nature of our universe. Major categories of cycles covered in this bibliography are: Astrophysics, Atmospheric Science, Biology, Botany, Geoscience, Medicine, Social Science, Zoology, and Interdisciplinary. Over 600 sources of information on thousands of cycles are carefully reviewed to enable the reader maximum access to the most substansive evidence for cycles in each field. A balance of general readings as well as more technical articles is maintained throughout the bibliography. An introduction provides an overview of the broad spectrum of information on cycles, indicating those areas of controversy as well as of agreement. The claims of cycles in social unrest, economics, and climatology are noted, as well as the more well-known cycles in biology, physiology, and medicine. The volume has an extensive table of contents to facilitate the location of many subcategories of cycles. An extensive index also enables the location of citations for specific researchers and for numerous subjects.

Introducing Biological Rhythms is a primer that serves to introduce individuals to the area of biological rhythms. It describes the major characteristics and discusses the implications and applications of these rhythms, while citing scientific results and references. Also, the primer includes essays that provide in-depth historic and other background information for those interested in more specific topics or concepts. It covers a basic cross-section of the field of chronobiology clearly enough so that it can be understood by a novice, or an undergraduate student, but that it would also be sufficiently technical and detailed for the scientist.

High blood pressure (BP) (with fats and smoking) is one of the three roots of cardio-cerebro-renovascular disease affecting up to 25% of the adult population. Hence, high blood pressure should be recognized and treated, to reduce any complications and prolong life, as noted by Michael Weber of the Veterans Administration Hospital in Long Beach, California. He further emphasizes the need for monitoring before one starts the treatment of high blood pressure. Indeed, he refers to the results of the Australian study on mild hypertension with a large percentage of placebo responders and rightly suggests that many people are treated who should not be because of 'white-coat-associated high blood pressure'. He also points to the lack of standardization of techniques for data analysis and of methods of BP measurement. Ambulatory monitoring under usual condi tions without concomitant recording of events does not allow even a qualitative assessment of the impact of varying stimuli, in weber's opinion.

There is a critical, bidirectional relationship between sleep and cognition, yet the literature in this area is scattered, and it is surprisingly difficult to find a comprehensive overview of the basic principles, latest discoveries, and outstanding challenges. This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on the topic in the basic, clinical and applied sciences. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery. - Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research - Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered - All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Previous volumes in this series have discussed the current progression have identified a variety of targets and strategies state of our knowledge concerning the pathophysiology of to allow these goals to be realized. This volume critically cancer growth and progression. The complexity of the in reviews approaches towards cancer management in man at teraction of malignant neoplasms and the host, the the levels of: detection, diagnosis, surgery, radiology, heterogeneity of malignant cell subpopulations, and the chronobiology and endocrine treatment. existence of metastatic tumor cells resistant to drug thera Several chapters review selected methods of cancer diag pies remain as significant clinical challenges to clinical on nosis. In addition, a variety of on-going and novel ap cologists. Indeed, conventional treatment regimens of che proaches for cancer treatment are also presented in this volume. Progress in the early detection of malignant neo motherapy, surgery and radiology are often ineffective for the therapy of a large variety of established metastatic can plasms, coupled with novel approaches for the therapy of cer in patients. When one considers the insidiousness of such neoplasms, may ultimately yield safe and well-tolerated agents for the selective therapy of solid malignancies. New progressive neoplastic growth and the emergence of con tinuously more aggressive and malignant cellular subpop therapeutic approaches, directed towards the biochemical ulations one is overwhelmed with the challenges inherent in and molecular targets identified in the earlier volumes of this series, may ultimately lead to the generation of new mo attempting to control malignant neoplasms.

Originally published in 1982, this book provides rich evidence of the relevance of the temporal aspects of behavior. The generalized areas of learning, memory, operant scheduled behavior, task performance, vigilance, mood and motivation and their rhythmic components are explored in varying detail. The particularized measures range from on-the-job errors, through reading efficiency to milliseconds of change in reaction time in the laboratory. The subjects range from ants to older persons. Across this range of settings, subjects, and behaviors, the message is clear: there is an interaction between time and behavior.