Chromosomal Alterations
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Author |
: Robert C. Bast, Jr. |
Publisher |
: John Wiley & Sons |
Total Pages |
: 2004 |
Release |
: 2017-03-10 |
ISBN-10 |
: 9781119000846 |
ISBN-13 |
: 111900084X |
Rating |
: 4/5 (46 Downloads) |
Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author |
: Marcelo Larramendy |
Publisher |
: BoD – Books on Demand |
Total Pages |
: 206 |
Release |
: 2017-08-30 |
ISBN-10 |
: 9789535134732 |
ISBN-13 |
: 9535134736 |
Rating |
: 4/5 (32 Downloads) |
Synopsis Chromosomal Abnormalities by : Marcelo Larramendy
This edited book, Chromosomal Abnormalities - A Hallmark Manifestation of Genomic Instability, contains a series of chapters highlighting several aspects related to the generation of chromosomal abnormalities in genetic material. We are extremely grateful to the authors who had contributed with valuable information about the role of genomic instability in pathological disorders as well as in the evolution process.
Author |
: Günter Obe |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 328 |
Release |
: 2012-12-06 |
ISBN-10 |
: 9783642756825 |
ISBN-13 |
: 3642756824 |
Rating |
: 4/5 (25 Downloads) |
Synopsis Chromosomal Aberrations by : Günter Obe
Chromosomale Mutationen sind eine der m|glichen Ursachen f}r Ver{nderungen der Erbinformation. Neben grunds{tzlichen As- pekten, wie Reparaturmechanismen der Zelle oder Ursachen von Chromosomenver{nderungen, werden angewandte Aspekte, z.B. Chromosomen als Testindikatoren der Toxizit{t, behandelt.
Author |
: Günter Obe |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 526 |
Release |
: 2007-06-02 |
ISBN-10 |
: 9783540714149 |
ISBN-13 |
: 3540714146 |
Rating |
: 4/5 (49 Downloads) |
Synopsis Chromosomal Alterations by : Günter Obe
The book helps the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and thus is of intense interest to all those interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields.
Author |
: Ilan R. Kirsch |
Publisher |
: CRC Press |
Total Pages |
: 556 |
Release |
: 1992-12-21 |
ISBN-10 |
: 0849388937 |
ISBN-13 |
: 9780849388934 |
Rating |
: 4/5 (37 Downloads) |
Synopsis The Causes and Consequences of Chromosomal Aberrations by : Ilan R. Kirsch
The Causes and Consequences of Chromosomal Aberrations explores one of the most dramatic examples of genomic instability-chromosomal aberrations. It describes some of the more recent techniques used to map genes within the human genome, study chromosomal aberrations at the cellular level, and define the organization of the interphase nucleus. General overviews are provided to build a conceptual framework for understanding the generality and specificity of chromosomal aberrations. The Causes and Consequences of Chromosomal Aberrations also explores the role of recombinases and topoisomerases in the development of chromosomal aberrations. It contains studies of chromosomal aberrations, which offer separate instructive treatises on specific malignancies. The Causes and Consequences of Chromosomal Aberrations is useful to medical and graduate students, physicians, molecular biologists, and cytogeneticists. It will benefit anyone interested in the concepts, contributions, and development in the field of molecular cytogenetics.
Author |
: National Research Council |
Publisher |
: National Academies |
Total Pages |
: 436 |
Release |
: 1990-02-01 |
ISBN-10 |
: 9780309039956 |
ISBN-13 |
: 0309039959 |
Rating |
: 4/5 (56 Downloads) |
Synopsis Health Effects of Exposure to Low Levels of Ionizing Radiation by : National Research Council
This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
Author |
: Alison Fiander |
Publisher |
: Cambridge University Press |
Total Pages |
: 557 |
Release |
: 2016-10-13 |
ISBN-10 |
: 9781107667136 |
ISBN-13 |
: 1107667135 |
Rating |
: 4/5 (36 Downloads) |
Synopsis MRCOG Part One by : Alison Fiander
A fully updated and illustrated handbook providing comprehensive coverage of all curriculum areas covered by the MRCOG Part 1 examination.
Author |
: Donna M. McDonald-McGinn |
Publisher |
: Academic Press |
Total Pages |
: 526 |
Release |
: 2022-08-19 |
ISBN-10 |
: 9780128160480 |
ISBN-13 |
: 0128160489 |
Rating |
: 4/5 (80 Downloads) |
Synopsis The Chromosome 22q11.2 Deletion Syndrome by : Donna M. McDonald-McGinn
The Chromosome 22q11.2 Deletion Syndrome: A Multidisciplinary Approach to Diagnosis and Treatment serves as the first comprehensive, user-friendly resource on the etiology, prognosis, and recurrence risk associated with the chromosome 22q11.2 deletion syndrome. Leading international contributors cover the background, genetics, testing methods, and pathophysiology of 22q11.2DS, placing emphasis on a strong foundation for multidisciplinary treatment strategies. Written by specialists in every applicable subspecialty, such as, cardiology, immunology, endocrinology, gastroenterology, hematology, ophthalmology, neurology, and psychiatry, among other fields. This book presents an authoritative resource with full color images that enhance concept illustration and aid in real-time decision-making. As 22q11.2 deletion syndrome has become a model for understanding rare and frequent anomalies, numerous medical issues, cognitive and behavioral phenotypes, and later onset conditions, this text will become the go to resource for clinicians, researchers, trainees, and motivated family members, in gaining a full understanding of this complex chromosomal disorder. - Provides a complete description of 22q11.2 deletion syndrome for healthcare professionals, researchers, trainees, and families affected by this common condition - Presents diagnostic and treatment strategies to help tackle this complex and often undiagnosed and therefore undertreated condition - Covered in a user-friendly, practical format that emphasizes evidence-based evaluation and treatment derived from the latest clinical experience and research in the field - Features leading international contributors in numerous sub-specialties, representing the multisystem nature of this condition - Includes full color figures, flow charts, tables, and patient images to guide real-time decision-making
Author |
: Vincenzo E. A. Russo |
Publisher |
: |
Total Pages |
: 716 |
Release |
: 1996 |
ISBN-10 |
: UOM:39015047449171 |
ISBN-13 |
: |
Rating |
: 4/5 (71 Downloads) |
Synopsis Epigenetic Mechanisms of Gene Regulation by : Vincenzo E. A. Russo
Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.
Author |
: Ramaswamy Govindan, MD |
Publisher |
: Springer Publishing Company |
Total Pages |
: 185 |
Release |
: 2019-01-28 |
ISBN-10 |
: 9780826168689 |
ISBN-13 |
: 082616868X |
Rating |
: 4/5 (89 Downloads) |
Synopsis Cancer Genomics for the Clinician by : Ramaswamy Govindan, MD
Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointestinal cancers, urologic cancers, head and neck cancer, thyroid cancer, and many more. Assembled in an accessible format specifically designed for the non-expert, this book provides the clinical oncologist, early career practitioner, and trainee with an essential understanding of the molecular and genetic basis of cancer and the clinical aspects that have led to advancements in diagnosis and treatment. With this resource, physicians and trainees will increase their breadth of knowledge and be better equipped to educate patients and families who want to know more about their genetic predispositions to cancer and the targeted therapies that could be considered and prescribed. Key Features: Describes how cancer genomics and next generation sequencing informs cancer screening, risk factors, therapeutic options, and clinical management across cancer types Explains what mutations are, what tests are needed, and how to interpret the results Provides information on FDA-approved targeted therapies that are being used in the clinic Covers different sequencing platforms and technologies and how they perform in research settings Includes access to the fully searchable eBook