Chemical Aspects Of Drug Delivery Systems
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Author |
: D R Karsa |
Publisher |
: Royal Society of Chemistry |
Total Pages |
: 172 |
Release |
: 2007-10-31 |
ISBN-10 |
: 9781847550378 |
ISBN-13 |
: 1847550371 |
Rating |
: 4/5 (78 Downloads) |
Synopsis Chemical Aspects of Drug Delivery Systems by : D R Karsa
Despite advances in the development of new drugs, a drug may never reach the target organ, or it may be difficult to achieve the necessary level of drug in the body. Large doses can result in serious side effects and can harm normal, as well as diseased, cells and organs, and for this reason it is vital that controlled release and the targeting of delivery systems must evolve in parallel to drug research. Chemical Aspects of Drug Delivery Systems reflects the modern challenge to devise effective drug delivery and targeting systems, giving particular emphasis to recent innovations in the field. Delivery systems described include carbohydrate derivatives, novel nonionic surfactant vesicles and various polymers, including polyacrylates and aqueous shellac solutions, as well as hydrogels. In addition, many of the key issues, such as the understanding of biosystems and targets and the development of materials to provide the deserved carrier and excipient properties for controlled, targeted drug delivery, are considered in depth. This book will be of equal interest to undergraduate, graduate, researcher and those in the pharmaceutical industries, and it complements two previous RSC Special Publications, Encapsulation and Controlled Release and Excipients and Delivery Systems for Pharmaceutical Formulations.
Author |
: Amit Singh |
Publisher |
: Royal Society of Chemistry |
Total Pages |
: 376 |
Release |
: 2018-07-09 |
ISBN-10 |
: 9781788014663 |
ISBN-13 |
: 1788014669 |
Rating |
: 4/5 (63 Downloads) |
Synopsis Stimuli-responsive Drug Delivery Systems by : Amit Singh
The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise “stimuli-responsive” materials for site-specific drug delivery applications. This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials. Setting the scene, the editors open with a chapter addressing the need for smart materials in delivery applications for therapy, imaging and disease diagnosis. The following chapter describes the key physical and chemical aspects of smart materials, from lipids to polymers to hybrid materials, providing the reader with a springboard to delve into the more application oriented chapters that follow. With in-depth coverage of key drug delivery systems such as pH-responsive, temperature responsive, enzyme-responsive and light responsive systems, this book provides a rigorous foundation to the field. A perfect resource for graduate students and newcomers, the closing chapter on regulatory and commercialization challenges also makes the book ideal for those wanting to take the next step towards clinical translation.
Author |
: Xiaoling Li |
Publisher |
: McGraw Hill Professional |
Total Pages |
: 453 |
Release |
: 2005-11-24 |
ISBN-10 |
: 9780071588836 |
ISBN-13 |
: 0071588833 |
Rating |
: 4/5 (36 Downloads) |
Synopsis Design of Controlled Release Drug Delivery Systems by : Xiaoling Li
The goal of every drug delivery system is to deliver the precise amount of a drug at a pre-programmed rate to the desired location in order to achieve the drug level necessary for the treatment. An essential guide for biomedical engineers and pharmaceutical designers, this resource combines physicochemical principles with physiological processes to facilitate the design of systems that will deliver medication at the time and place it is most needed.
Author |
: R. A. Stephenson |
Publisher |
: |
Total Pages |
: 162 |
Release |
: 1996 |
ISBN-10 |
: 1628701226 |
ISBN-13 |
: 9781628701227 |
Rating |
: 4/5 (26 Downloads) |
Synopsis Chemical Aspects of Drug Delivery by : R. A. Stephenson
Annotation The April 1996 proceedings address the challenges of developing drugs with delivery systems that target the correct organ and achieve the necessary level of drug in the body. New materials and systems for drug delivery targeting are reviewed in the 15 presentations, including aspects of bioadhesive polymers, novel nonionic surfactant vesicles, hydrogels based on poly(ethylene glycols), monofunctional poly(ethylene glycol), and aqueous shellac solutions. Annotation c. by Book News, Inc., Portland, Or.
Author |
: Richard B. Silverman |
Publisher |
: Elsevier |
Total Pages |
: 650 |
Release |
: 2012-12-02 |
ISBN-10 |
: 9780080513379 |
ISBN-13 |
: 0080513379 |
Rating |
: 4/5 (79 Downloads) |
Synopsis The Organic Chemistry of Drug Design and Drug Action by : Richard B. Silverman
Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. - New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations - Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years - Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization
Author |
: R. L. Juliano |
Publisher |
: Oxford University Press, USA |
Total Pages |
: 346 |
Release |
: 1980 |
ISBN-10 |
: UCAL:B4527596 |
ISBN-13 |
: |
Rating |
: 4/5 (96 Downloads) |
Synopsis Drug Delivery Systems by : R. L. Juliano
Author |
: Md Saquib Hasnain |
Publisher |
: Academic Press |
Total Pages |
: 557 |
Release |
: 2021-10-26 |
ISBN-10 |
: 9780128193372 |
ISBN-13 |
: 0128193379 |
Rating |
: 4/5 (72 Downloads) |
Synopsis Chitosan in Drug Delivery by : Md Saquib Hasnain
Chitosan in Drug Delivery provides thorough insights into chitosan chemistry, collection, chemical modifications, characterization and applications in the pharmaceutical industry and healthcare fields. The book explores molecular weight, degree of deacetylation and molecular geometry, emphasizing recent advances in the field as written by academic, industry and regulatory scientists. It will be a useful resource for pharmaceutical scientists, including industrial pharmacists, analytical scientists, postgraduate students, health care professionals and regulatory scientists actively involved in pharmaceutical product and process development in natural polymers containing drug delivery. Provides methodologies for the design, development and selection of chitosan in drug delivery for particular therapeutic applications Includes illustrations demonstrating the mechanism of biological interaction of chitosan Discusses the regulatory aspects and demonstrates the clinical efficacy of chitosan
Author |
: Katarzyna Winnicka |
Publisher |
: MDPI |
Total Pages |
: 234 |
Release |
: 2021-09-03 |
ISBN-10 |
: 9783036510583 |
ISBN-13 |
: 3036510583 |
Rating |
: 4/5 (83 Downloads) |
Synopsis Advanced Materials in Drug Release and Drug Delivery Systems by : Katarzyna Winnicka
Development of new drug molecules is costly and requires longitudinal, wide-ranging studies; therefore, designing advanced pharmaceutical formulations for existing and well-known drugs seems to be an attractive device for the pharmaceutical industry. Properly formulated drug delivery systems can improve pharmacological activity, efficacy and safety of the active substances. Advanced materials applied as pharmaceutical excipients in designing drug delivery systems can help solve problems concerning the required drug release—with the defined dissolution rate and at the determined site. Novel drug carriers enable more effective drug delivery, with improved safety and with fewer side effects. Investigations concerning advanced materials represent a rapidly growing research field in material/polymer science, chemical engineering and pharmaceutical technology. Exploring novel materials or modifying and combining existing ones is now a crucial trend in pharmaceutical technology. Eleven articles included in the the Special Issue “Advanced Materials in Drug Release and Drug Delivery Systems” present the most recent insights into the utilization of different materials with promising potential in drug delivery and into different formulation approaches that can be used in the design of pharmaceutical formulations.
Author |
: Ranjita Shegokar |
Publisher |
: Academic Press |
Total Pages |
: 268 |
Release |
: 2020-03-27 |
ISBN-10 |
: 9780128218501 |
ISBN-13 |
: 0128218509 |
Rating |
: 4/5 (01 Downloads) |
Synopsis Drug Delivery Aspects by : Ranjita Shegokar
Drug Delivery Aspects reviews additional features of drug delivery systems, along with the standard formulation development, like preclinical testing, conversion into solid dosage forms, roles of excipients and polymers used on stability and sterile processing. There is a focus on formulation engineering and related large scale (GMP) manufacturing, regulatory, and functional aspects of drug delivery systems. A detailed discussion on biologics and vaccines gives insights to readers on new developments in this direction. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. - Encompasses engineering and large-scale manufacturing of nanocarriers - Considers preclinical, regulatory and ethical guidelines on nanoparticles - Contains in-depth discussions on delivery of biologics, vaccines and sterilisation - Industrial view on solid dispersions, milling techniques
Author |
: Michael S. Roberts |
Publisher |
: John Wiley & Sons |
Total Pages |
: 580 |
Release |
: 2021-09-30 |
ISBN-10 |
: 9781119769675 |
ISBN-13 |
: 1119769671 |
Rating |
: 4/5 (75 Downloads) |
Synopsis Fundamentals of Drug Delivery by : Michael S. Roberts
A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.