This book provides a comprehensive overview of the unique challenges inherent in pediatric kidney transplantation. The text reviews the problems faced during each stage of the kidney transplantation process, including the occurrence of infections during the pre-transplant stage, surgical challenges during the actual transplantation, and medication issues during the post-transplant stage. The book also features high-yield case presentations of typical pediatric transplant scenarios, from the pre-transplant management of a child with CAKUT to the evaluation and treatment of antibody mediated rejection in children. Written by experts in the field, Challenges in Pediatric Kidney Transplantation: A Practical Guide is a valuable resource for clinicians, practitioners, and trainees who manage or are interested in this challenging group of patients.

This book offers a theoretical and practical overview of the specific ethical and legal issues in pediatric organ transplantation. Written by a team of leading experts, Ethical Issues in Pediatric Organ Transplantation addresses those difficult ethical questions concerning clinical, organizational, legal and policy issues including donor, recipient and allocation issues. Challenging topics, including children as donors, donation after cardiac death, misattributed paternity, familial conflicts of interest, developmental disability as a listing criteria, small bowel transplant, and considerations in navigating the media are discussed. It serves as a fundamental handbook and resource for pediatricians, transplant health care professionals, trainees, graduate students, scholars, practitioners of bioethics and health policy makers.

A detailed, contributed reference offering broad coverage of renal transplantation in children. Diagnosis, the patient's medical management, operative methods, surgical and medical complications, donor selection, immunosuppression, late effects on growth and development and psychosocial factors are among the topics discussed. Features a chapter on how to set up and manage a pediatric renal transplant program.

The role of immunosuppression is essential to maintain the integrity of a renal transplant by preventing acute rejection. Among adult patients with solid organ transplants, standard immunosuppression does not vary among the major transplant centres in the USA and Europe, and consists of corticosteroids, calcineurin inhibitors and mycophenolic acid. However, children with renal transplants are more susceptible than adults to suffer adverse events related to this standard protocol, including short stature, nephrotoxicity, lymph proliferative disease and infections. For this reason, paediatric nephrologists have explored alternatives to standard immunosuppression while still maintaining acceptable graft outcomes. This book will explore this theme, which will include several chapters that present alternative immunosuppression protocol, in addition to other chapters that address challenging and controversial issues in paediatric renal transplantation. The first three chapters will describe immunosuppression protocols which may have specific benefits in children with renal allografts compared to standard regimens in adults. This includes the use of steroid-avoidance, which obviates many of the problems associated with corticosteroid use in children especially short stature and obesity. Secondly, the mTOR inhibitor Sirolimus is thoroughly discussed, including the potential benefits of this agent because of its lack of nephrotoxicity and possible anti-neoplastic properties. Lastly, induction therapy with Alemtuzumab is described, including recent studies that suggest that this agent may have definite benefits in children compared to standard induction with anti-thymocyte globulin.

This e-book is an overview of recent advances in the realm of kidney transplantation. The volume discusses developments in surgical procedures while presenting a perspective on possibilities for kidney transplant research in the future. The e-book is a c

Challenges and Controversies in Kidney Transplantation highlights the most up-to-date strategies for successfully managing high-risk kidney transplant recipients, as well as detailed, innovative strategies to increase transplant opportunities for patients requiring kidney transplantation. The book is divided into two major sections; firstly, Maximizing Transplant Opportunities, and second, Considerations for Unique/High Risk Patient Populations focusing on management of select patient populations, such as children, the elderly, HIV, Hepatitis C positive patents, highly sensitized patients, and patients who develop post-transplant polyomavirus nephropathy. Surgical topics include Laparoendoscopic Single Site and Robotic Donor Nephrectomy as minimally invasive surgical procedures to increase living donation, and the use of Paediatric Donor Kidneys in deceased donor kidney transplantation. In addition, Challenges and Controversies in Kidney Transplantation also features discussion on the most difficult clinical management issues confronting Kidney Transplantation today, making it a relevant and essential reference for nephrologists, neurologists and residents. Key Points Concise and comprehensive guide to problems associated with kidney transplantation Full colour illustrations Authored by Sandip Kapur, Professor of Surgery at Weill Medical College – Cornell University, USA

Written and edited by global leaders in the field, Pediatric Liver Transplantation: A Clinical Guide covers all aspects of treatment and management regarding this multifaceted procedure and unique patient population. This practical reference offers detailed, focused guidance in a highly templated, easy-to-consult format, covering everything from pre-transplantation preparation to surgical techniques to post-operative complications. Provides an in-depth understanding of all aspects of pediatric liver transplantation, ideal for pediatric hepatologists, pediatric transplant surgeons, and others on the pediatric transplant team. Covers all surgical techniques in detail, including split graft, living related, auxiliary, and domino. Discusses pediatric liver transplantation consideration for an increasing number of additional metabolic, hematologic and renal conditions; breakthroughs in grafting and stem cell therapy; and techniques and present role of hepatocyte transplantation. Uses a quick-reference templated format; each chapter includes an overview, pathophysiology, conventional management, controversies, and bulleted summary of key take-aways. Includes state-of-the-art mini-reviews based on updated references and author experience throughout the text. Features a full-color design with numerous algorithms, figures, and radiological and histopathological photos.

The responsibilities of the Pediatric Nephrologist in the Nephrologist and other involved specialists is vital to critical care setting are multifaceted. Management of optimize the outcome for each individual child. acute renal failure with and without renal replacement In this first edition of the book, we have included therapy, fluid and electrolyte abnormalities and hyper- chapters focused on general topics in pediatric nephr- tensive emergencies are only some of the major clinical ogy that are most germane to the care of the critically circumstances where the renal specialist is involved in ill child. We have tried to look at the clinical situations the care of children admitted to the Pediatric Intensive from the aspect of both the Pediatric Intensivist and Care Unit. Due to the complex and specialized care renal specialist. We hope that this book will supply the required, critical care nephrology could even be consid- medical providers with a framework to approach the ered a separate entity compared to the clinical scenar- challenges faced in practicing Pediatric Intensive Care ios treated in the outpatient setting or on the inpatient Nephrology. pediatric ward.