Cgmp Generators Effectors And Therapeutic Implications
Download Cgmp Generators Effectors And Therapeutic Implications full books in PDF, epub, and Kindle. Read online free Cgmp Generators Effectors And Therapeutic Implications ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads.
Author |
: Harald H. H. W. Schmidt |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 581 |
Release |
: 2008-12-17 |
ISBN-10 |
: 9783540689645 |
ISBN-13 |
: 3540689648 |
Rating |
: 4/5 (45 Downloads) |
Synopsis cGMP: Generators, Effectors and Therapeutic Implications by : Harald H. H. W. Schmidt
After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.
Author |
: Harald H. H. W. Schmidt |
Publisher |
: Springer |
Total Pages |
: 583 |
Release |
: 2009-08-29 |
ISBN-10 |
: 3540864695 |
ISBN-13 |
: 9783540864691 |
Rating |
: 4/5 (95 Downloads) |
Synopsis cGMP: Generators, Effectors and Therapeutic Implications by : Harald H. H. W. Schmidt
After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.
Author |
: Harald H. H. W. Schmidt |
Publisher |
: Springer Nature |
Total Pages |
: 425 |
Release |
: 2021-02-23 |
ISBN-10 |
: 9783030685102 |
ISBN-13 |
: 3030685101 |
Rating |
: 4/5 (02 Downloads) |
Synopsis Reactive Oxygen Species by : Harald H. H. W. Schmidt
Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author |
: José Marín-García |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 511 |
Release |
: 2011-06-21 |
ISBN-10 |
: 9781441994615 |
ISBN-13 |
: 1441994610 |
Rating |
: 4/5 (15 Downloads) |
Synopsis Signaling in the Heart by : José Marín-García
Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact. This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions. Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology. It is an invaluable reference for cardiology researchers and practitioners.
Author |
: Roland Seifert |
Publisher |
: Springer |
Total Pages |
: 379 |
Release |
: 2017-04-28 |
ISBN-10 |
: 9783319526737 |
ISBN-13 |
: 3319526731 |
Rating |
: 4/5 (37 Downloads) |
Synopsis Non-canonical Cyclic Nucleotides by : Roland Seifert
The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3’,5’-cCMP and 3’,5’-cUMP, the purine nucleotide 3’,5’-cIMP, the 2’,3’-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3’,5’-cCMP and 3’,5’-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3’,5’-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.
Author |
: Thomas Brand |
Publisher |
: MDPI |
Total Pages |
: 307 |
Release |
: 2018-07-10 |
ISBN-10 |
: 9783038429890 |
ISBN-13 |
: 3038429899 |
Rating |
: 4/5 (90 Downloads) |
Synopsis Cyclic Nucleotide Signaling and the Cardiovascular System by : Thomas Brand
This book is a printed edition of the Special Issue "Cyclic Nucleotide Signaling and the Cardiovascular System" that was published in JCDD
Author |
: Aise Seda Artis |
Publisher |
: BoD – Books on Demand |
Total Pages |
: 167 |
Release |
: 2012-04-25 |
ISBN-10 |
: 9789535105596 |
ISBN-13 |
: 9535105590 |
Rating |
: 4/5 (96 Downloads) |
Synopsis Hemodynamics by : Aise Seda Artis
Hemodynamics is study of the mechanical and physiologic properties controlling blood pressure and flow through the body. The factors influencing hemodynamics are complex and extensive. In addition to systemic hemodynamic alterations, microvascular alterations are frequently observed in critically ill patients. The book "Hemodynamics: New Diagnostic and Therapeuric Approaches" is formed to present the up-to-date research under the scope of hemodynamics by scientists from different backgrounds.
Author |
: Marc Humbert |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 569 |
Release |
: 2013-10-04 |
ISBN-10 |
: 9783642386640 |
ISBN-13 |
: 3642386644 |
Rating |
: 4/5 (40 Downloads) |
Synopsis Pharmacotherapy of Pulmonary Hypertension by : Marc Humbert
This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.
Author |
: Viacheslav Nikolaev |
Publisher |
: Springer |
Total Pages |
: 383 |
Release |
: 2017-09-19 |
ISBN-10 |
: 9783319545790 |
ISBN-13 |
: 3319545795 |
Rating |
: 4/5 (90 Downloads) |
Synopsis Microdomains in the Cardiovascular System by : Viacheslav Nikolaev
The book comprehensively presents new findings in cardiovascular research related to signaling microdomains in health and disease. Important second messengers such as cAMP, cGMP, calcium and their role in microdomain signaling are discussed. The book offers and explains methodical approaches and technical ways how to successfully analyze microdomain signaling, also in the context of disease. It further provides scientific perspectives and strategies that are based on the concept of signaling within microdomains and that can revolutionize pharmacology and eventually lead to the effective treatment of cardiovascular diseases in future.This book is written for scientists in cardiovascular research, pharmacology, molecular and cellular biology as well as medical doctors in cardiology, angiology and nephrology.
Author |
: Kunihiro Sakuma |
Publisher |
: BoD – Books on Demand |
Total Pages |
: 132 |
Release |
: 2021-07-07 |
ISBN-10 |
: 9781839686504 |
ISBN-13 |
: 1839686502 |
Rating |
: 4/5 (04 Downloads) |
Synopsis Muscle Cell and Tissue by : Kunihiro Sakuma
The loss of skeletal muscle mass and strength substantially impairs physical performance and quality of life. This book details some approaches to the treatment of muscle wasting. It also reviews novel applications against pulmonary arterial hypertension such as cell reprogramming and the use of anticancer drugs that induce programmed cell death. Vascular smooth muscle cells (VSMCs) are the most prevalent cell types in blood vessels and serve critical regulatory roles. This publication also introduces mathematical models concerning the molecular mechanism and targets of cyclic guanosine 3′,5′-monophosphate (cGMP) in the contraction of VSMCs. This book will be of interest to professionals in clinical practice, medical and health care students, and researchers working in muscle-related fields of science.