Cell Mechanics And Tumor Development
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Author |
: Ronald L. Huston |
Publisher |
: |
Total Pages |
: 458 |
Release |
: 2020 |
ISBN-10 |
: 9789811208959 |
ISBN-13 |
: 9811208956 |
Rating |
: 4/5 (59 Downloads) |
Synopsis Cell Mechanics and Tumor Development by : Ronald L. Huston
Author |
: Cheng Dong |
Publisher |
: Springer |
Total Pages |
: 378 |
Release |
: 2018-10-27 |
ISBN-10 |
: 9783319952949 |
ISBN-13 |
: 3319952943 |
Rating |
: 4/5 (49 Downloads) |
Synopsis Biomechanics in Oncology by : Cheng Dong
This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology. This book also: Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic process Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy Includes insight into NCIs’ role in supporting biomechanics in oncology research Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer
Author |
: Roland Kaunas |
Publisher |
: CRC Press |
Total Pages |
: 380 |
Release |
: 2014-10-23 |
ISBN-10 |
: 9781466553811 |
ISBN-13 |
: 1466553812 |
Rating |
: 4/5 (11 Downloads) |
Synopsis Cell and Matrix Mechanics by : Roland Kaunas
Explores a Range of Multiscale Biomechanics/Mechanobiology Concepts Cell and Matrix Mechanics presents cutting-edge research at the molecular, cellular, and tissue levels in the field of cell mechanics. This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forces in cell–matrix interactions. Providing material in each chapter that builds on the previous chapters, it effectively integrates length scales and contains, for each length scale, key experimental observations and corresponding quantitative theoretical models. Summarizes the Three Hierarchical Levels of Cell Mechanics The book contains 14 chapters and is organized into three sections. The first section focuses on the molecular level, the second section details mechanics at the cellular level, and the third section explores cellular mechanics at the tissue level. The authors offer a thorough description of the roles of mechanical forces in cell and tissue biology, and include specific examples. They incorporate descriptions of associated theoretical models, and provide the data and modeling framework needed for a multi-scale analysis. In addition, they highlight the pioneering studies in cell–matrix mechanics by Albert K. Harris. The topics covered include: The passive and active mechanical properties of cytoskeletal polymers and associated motor proteins along with the behavior of polymer networks The mechanical properties of the cell membrane, with an emphasis on membrane protein activation caused by membrane forces The hierarchical organization of collagen fibrils, revealing that a delicate balance exists between specific and nonspecific interactions to result in a structure with semicrystalline order as well as loose associations The roles of matrix mechanical properties on cell adhesion and function along with different mechanical mechanisms of cell–cell interactions The effects of mechanical loading on cell cytoskeletal remodeling, summarizing various modeling approaches that explain possible mechanisms regulating the alignment of actin stress fibers in response to stretching The mechanical testing of cell-populated collagen matrices, along with theory relating the passive and active mechanical properties of the engineered tissues Cell migration behavior in 3-D matrices and in collective cell motility The role of mechanics in cartilage development The roles of both cellular and external forces on tissue morphogenesis The roles of mechanical forces on tumor growth and cancer metastasis Cell and Matrix Mechanics succinctly and systematically explains the roles of mechanical forces in cell–matrix biology. Practitioners and researchers in engineering and physics, as well as graduate students in biomedical engineering and mechanical engineering related to mechanobiology, can benefit from this work.
Author |
: |
Publisher |
: |
Total Pages |
: 0 |
Release |
: 2002 |
ISBN-10 |
: 0815332181 |
ISBN-13 |
: 9780815332183 |
Rating |
: 4/5 (81 Downloads) |
Synopsis Molecular Biology of the Cell by :
Author |
: Arnaud Chauvière |
Publisher |
: CRC Press |
Total Pages |
: 484 |
Release |
: 2010-01-27 |
ISBN-10 |
: 9781420094558 |
ISBN-13 |
: 1420094556 |
Rating |
: 4/5 (58 Downloads) |
Synopsis Cell Mechanics by : Arnaud Chauvière
Ubiquitous and fundamental in cell mechanics, multiscale problems can arise in the growth of tumors, embryogenesis, tissue engineering, and more. Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling brings together new insight and research on mechanical, mathematical, physical, and biological approaches for simulating the behavior
Author |
: Bernard S Gerstman |
Publisher |
: World Scientific |
Total Pages |
: 279 |
Release |
: 2020-12-03 |
ISBN-10 |
: 9789811223501 |
ISBN-13 |
: 9811223505 |
Rating |
: 4/5 (01 Downloads) |
Synopsis Physics Of Cancer, The: Research Advances by : Bernard S Gerstman
Cancer deaths per capita have decreased in recent years, but the improvement is attributed to prevention, not treatment. The difficulty in treating cancer may be due to its 'complexity', in the mathematical physics sense of the word. Tumors evolve and spread in response to internal and external factors that involve feedback mechanisms and nonlinear behavior. Investigations of the nonlinear interactions among cells, and between cells and their environment, are crucial for developing a sufficiently detailed understanding of the system's emergent phenomenology to be able to control the behavior. In the case of cancer, controlling the system's behavior will mean the ability to treat and cure the disease. Physicists have been studying various complex, nonlinear systems for many years using a variety of techniques. These investigations have provided insights that allow physicists to make unique contributions towards the treatment of cancer.This interdisciplinary book presents recent advancements in physicists' research on cancer. The work presented in this volume uses a variety of physical, biochemical, mathematical, theoretical, and computational techniques to gain a deeper molecular and cellular understanding of the horrific disease that is cancer.
Author |
: Erin Lynnette Baker |
Publisher |
: |
Total Pages |
: 370 |
Release |
: 2010 |
ISBN-10 |
: OCLC:776673724 |
ISBN-13 |
: |
Rating |
: 4/5 (24 Downloads) |
Synopsis Integrated Roles of Mechanics, Motility, and Disease Progression in Cancer by : Erin Lynnette Baker
The broad objective of this research is to examine the relationship between the cellular micromechanical environment and disease progression in cancer. The mechanical stiffness of cancerous tissue is a key feature that distinguishes it from normal tissue and thus facilitates its detection clinically. While numerous inroads have been achieved toward elucidating molecular mechanisms that underlie diseases such as cancer, quantitative characterization of associated cellular mechanical properties and biophysical attributes remains largely incomplete. To this end, the present research provides insight into the following questions: (1) What is the effect of extracellular matrix (ECM) stiffness and architecture on internal cancer cell rheology and cytoskeletal organization? (2) What are the integrated effects of ECM stiffness and cell metastatic potential on the intracellular rheology and morphology of breast cancer cells? (3) What are the integrated effects of ECM stiffness, ECM architecture, and cell metastatic potential on the motility of breast cancer cells? To examine these phenomena, the present research utilizes a multidisciplinary engineering approach that integrates experimental rheology, theoretical mechanics, confocal microscopy, computational algorithms, and experimental cell biology. Briefly, genetically altered cancer-mimicking cells are cultured within synthetic ECMs of varying mechanical stiffness and structure, where they are then observed using time-lapsed confocal microscopy. Image analyses and computational algorithms are then employed to extract measures of cell migration speed and intracellular stiffness via particle-tracking microrheology techniques. Major results show that ECM stiffness elicits an intracellular mechanical response only within the framework of physiologically relevant matrix environments and that a key cell-matrix attachment protein (the integrin) plays an essential role in this phenomenon. Additional results indicate that a well-known breast cancer-associated biomarker (ErbB2) is responsible for sensitizing mammary cells to ECM stiffness. Finally, results also show that a switch in ECM architecture significantly hinders the migratory capacity of ErbB2-associated cells, which may explain why the ErbB2 biomarker is detected with much higher frequency in early stage breast cancer than in later stage invasive and metastatic cancers. In total, these findings inform the fields of mechanobiology and cancer biology by systematically linking cell rheology, cell motility, matrix mechanics, and disease progression in cancer.
Author |
: A. Wagoner Johnson |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 329 |
Release |
: 2011-02-21 |
ISBN-10 |
: 9781441980830 |
ISBN-13 |
: 1441980830 |
Rating |
: 4/5 (30 Downloads) |
Synopsis Mechanobiology of Cell-Cell and Cell-Matrix Interactions by : A. Wagoner Johnson
Mechanobiology of Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, (molecular and cellular) biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. Topics include adhesive and integrin-ligand interactions; extracellular influences on cell biology and behavior; cooperative mechanisms of cell-cell and cell-matrix interactions; the mechanobiology of pathological processes; (multi-scale) modeling approaches to describe the complexity or cell-matrix interactions; and quantitative methods required for such experimental and modeling studies.
Author |
: Claudia Mierke |
Publisher |
: Iph001 |
Total Pages |
: 500 |
Release |
: 2018-10-24 |
ISBN-10 |
: 0750317515 |
ISBN-13 |
: 9780750317511 |
Rating |
: 4/5 (15 Downloads) |
Synopsis Physics of Cancer by : Claudia Mierke
This revised second edition is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.
Author |
: Stephanie Mok |
Publisher |
: |
Total Pages |
: 0 |
Release |
: 2021 |
ISBN-10 |
: OCLC:1342593409 |
ISBN-13 |
: |
Rating |
: 4/5 (09 Downloads) |
Synopsis Quantifying Three-dimensional Cell-scale Mechanics in Cancer Using Thermally Responsive Hydrogel Probes by : Stephanie Mok
"The combination of the mechanical properties of the extracellular matrix, the cells and their physical arrangement influences how cells sense and respond to the microenvironment. In diseases such as cancer where metastatic events led by a few cells are responsible for mortality, characterizing how local mechanics change and influence cell behavior can provide an important understanding of disease progression. In this thesis, a novel sensor to measure internal mechanics at cellular length scales, within 3D tumor tissue models was developed. Fluorescently-labelled swellable microgels, called microscale temperature-actuated mechanosensors (æTAMs), were developed as cell-sized mechanosensors that report local mechanics based on their ability to expand within a matrix. These sensors were first used in spheroid cultures and mouse models to reveal local sites of high stiffness in invasive cancers. Similar trends were observed in extended spheroid cultures of a Src inducible cell line where high stiffnesses occurred while the oncogene was constitutively expressed and there was space to grow freely. Histological examination of soft versus stiff localized areas within spheroids revealed distinct differences in morphology suggesting differences in cellular mechanical responses at these regions. Finally, the æTAMs were further developed to extend their capabilities for cell-scale viscoelastic measurements which better describe the early cell response and behavior to mechanical stress. Differences in viscoelastic behaviors at the cellular length scale were identified between invasive and non-invasive cancer spheroids where invasive tissue appear to behave more elastically than viscous behaviors in non-invasive spheroids. Overall, the development of the æTAM sensor allows us to study optically study internal tissue mechanics and has identified highly localized mechanical properties surrounding individual cells that correlate with invasive potential"--