This volume in the Challenges in Machine Learning series gathers papers from the Mini Symposium on Causality in Time Series, which was part of the Neural Information Processing Systems (NIPS) confernce in 2009 in Vancouver, Canada. These papers present state-of-the-art research in time-series causality to the machine learning community, unifying methodological interests in the various communities that require such inference.

This book presents ground-breaking advances in the domain of causal structure learning. The problem of distinguishing cause from effect (“Does altitude cause a change in atmospheric pressure, or vice versa?”) is here cast as a binary classification problem, to be tackled by machine learning algorithms. Based on the results of the ChaLearn Cause-Effect Pairs Challenge, this book reveals that the joint distribution of two variables can be scrutinized by machine learning algorithms to reveal the possible existence of a “causal mechanism”, in the sense that the values of one variable may have been generated from the values of the other. This book provides both tutorial material on the state-of-the-art on cause-effect pairs and exposes the reader to more advanced material, with a collection of selected papers. Supplemental material includes videos, slides, and code which can be found on the workshop website. Discovering causal relationships from observational data will become increasingly important in data science with the increasing amount of available data, as a means of detecting potential triggers in epidemiology, social sciences, economy, biology, medicine, and other sciences.

This paper summarizes recent advances in causal inference and underscores the paradigmatic shifts that must be undertaken in moving from traditional statistical analysis to causal analysis of multivariate data. Special emphasis is placed on the assumptions that underly all causal inferences, the languages used in formulating those assumptions, the conditional nature of all causal and counterfactual claims, and the methods that have been developed for the assessment of such claims. These advances are illustrated using a general theory of causation based on the Structural Causal Model (SCM) described in Pearl (2000a), which subsumes and unifies other approaches to causation, and provides a coherent mathematical foundation for the analysis of causes and counterfactuals. In particular, the paper surveys the development of mathematical tools for inferring (from a combination of data and assumptions) answers to three types of causal queries: (1) queries about the effects of potential interventions, (also called "causal effects" or "policy evaluation") (2) queries about probabilities of counterfactuals, (including assessment of "regret," "attribution" or "causes of effects") and (3) queries about direct and indirect effects (also known as "mediation"). Finally, the paper defines the formal and conceptual relationships between the structural and potential-outcome frameworks and presents tools for a symbiotic analysis that uses the strong features of both. The tools are demonstrated in the analyses of mediation, causes of effects, and probabilities of causation. -- p. 1.

A concise and self-contained introduction to causal inference, increasingly important in data science and machine learning. The mathematization of causality is a relatively recent development, and has become increasingly important in data science and machine learning. This book offers a self-contained and concise introduction to causal models and how to learn them from data. After explaining the need for causal models and discussing some of the principles underlying causal inference, the book teaches readers how to use causal models: how to compute intervention distributions, how to infer causal models from observational and interventional data, and how causal ideas could be exploited for classical machine learning problems. All of these topics are discussed first in terms of two variables and then in the more general multivariate case. The bivariate case turns out to be a particularly hard problem for causal learning because there are no conditional independences as used by classical methods for solving multivariate cases. The authors consider analyzing statistical asymmetries between cause and effect to be highly instructive, and they report on their decade of intensive research into this problem. The book is accessible to readers with a background in machine learning or statistics, and can be used in graduate courses or as a reference for researchers. The text includes code snippets that can be copied and pasted, exercises, and an appendix with a summary of the most important technical concepts.

Artificial Intelligence and Causal Inference address the recent development of relationships between artificial intelligence (AI) and causal inference. Despite significant progress in AI, a great challenge in AI development we are still facing is to understand mechanism underlying intelligence, including reasoning, planning and imagination. Understanding, transfer and generalization are major principles that give rise intelligence. One of a key component for understanding is causal inference. Causal inference includes intervention, domain shift learning, temporal structure and counterfactual thinking as major concepts to understand causation and reasoning. Unfortunately, these essential components of the causality are often overlooked by machine learning, which leads to some failure of the deep learning. AI and causal inference involve (1) using AI techniques as major tools for causal analysis and (2) applying the causal concepts and causal analysis methods to solving AI problems. The purpose of this book is to fill the gap between the AI and modern causal analysis for further facilitating the AI revolution. This book is ideal for graduate students and researchers in AI, data science, causal inference, statistics, genomics, bioinformatics and precision medicine. Key Features: Cover three types of neural networks, formulate deep learning as an optimal control problem and use Pontryagin’s Maximum Principle for network training. Deep learning for nonlinear mediation and instrumental variable causal analysis. Construction of causal networks is formulated as a continuous optimization problem. Transformer and attention are used to encode-decode graphics. RL is used to infer large causal networks. Use VAE, GAN, neural differential equations, recurrent neural network (RNN) and RL to estimate counterfactual outcomes. AI-based methods for estimation of individualized treatment effect in the presence of network interference.

Discovering Causal Structure: Artificial Intelligence, Philosophy of Science, and Statistical Modeling provides information pertinent to the fundamental aspects of a computer program called TETRAD. This book discusses the version of the TETRAD program, which is designed to assist in the search for causal explanations of statistical data. or alternative models. This text then examines the notion of applying artificial intelligence methods to problems of statistical model specification. Other chapters consider how the TETRAD program can help to find god alternative models where they exist, and how it can help detect the existence of important neglected variables. This book discusses as well the procedures for specifying a model or models to account for non-experimental or quasi-experimental data. The final chapter presents a description of the format of input files and a description of each command. This book is a valuable resource for social scientists and researchers.

This book is about making machine learning models and their decisions interpretable. After exploring the concepts of interpretability, you will learn about simple, interpretable models such as decision trees, decision rules and linear regression. Later chapters focus on general model-agnostic methods for interpreting black box models like feature importance and accumulated local effects and explaining individual predictions with Shapley values and LIME. All interpretation methods are explained in depth and discussed critically. How do they work under the hood? What are their strengths and weaknesses? How can their outputs be interpreted? This book will enable you to select and correctly apply the interpretation method that is most suitable for your machine learning project.

A Turing Award-winning computer scientist and statistician shows how understanding causality has revolutionized science and will revolutionize artificial intelligence "Correlation is not causation." This mantra, chanted by scientists for more than a century, has led to a virtual prohibition on causal talk. Today, that taboo is dead. The causal revolution, instigated by Judea Pearl and his colleagues, has cut through a century of confusion and established causality -- the study of cause and effect -- on a firm scientific basis. His work explains how we can know easy things, like whether it was rain or a sprinkler that made a sidewalk wet; and how to answer hard questions, like whether a drug cured an illness. Pearl's work enables us to know not just whether one thing causes another: it lets us explore the world that is and the worlds that could have been. It shows us the essence of human thought and key to artificial intelligence. Anyone who wants to understand either needs The Book of Why.

The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the target parameter representing the scientific question of interest. This book is aimed at both statisticians and applied researchers interested in causal inference and general effect estimation for observational and experimental data. Part I is an accessible introduction to super learning and the targeted maximum likelihood estimator, including related concepts necessary to understand and apply these methods. Parts II-IX handle complex data structures and topics applied researchers will immediately recognize from their own research, including time-to-event outcomes, direct and indirect effects, positivity violations, case-control studies, censored data, longitudinal data, and genomic studies.

CAUSAL INFERENCE IN STATISTICS A Primer Causality is central to the understanding and use of data. Without an understanding of cause–effect relationships, we cannot use data to answer questions as basic as "Does this treatment harm or help patients?" But though hundreds of introductory texts are available on statistical methods of data analysis, until now, no beginner-level book has been written about the exploding arsenal of methods that can tease causal information from data. Causal Inference in Statistics fills that gap. Using simple examples and plain language, the book lays out how to define causal parameters; the assumptions necessary to estimate causal parameters in a variety of situations; how to express those assumptions mathematically; whether those assumptions have testable implications; how to predict the effects of interventions; and how to reason counterfactually. These are the foundational tools that any student of statistics needs to acquire in order to use statistical methods to answer causal questions of interest. This book is accessible to anyone with an interest in interpreting data, from undergraduates, professors, researchers, or to the interested layperson. Examples are drawn from a wide variety of fields, including medicine, public policy, and law; a brief introduction to probability and statistics is provided for the uninitiated; and each chapter comes with study questions to reinforce the readers understanding.