This comprehensive, ground-breaking title presents, in simplifying style, the driving and organizing principles of cancer, making this multidimensional, highly complex disease easily understandable for readers. Developed out of the renowned author’s many years of teaching a widely popular, several-hundred-student college course, this 12-chapter book begins with an account of the history of cancer as a medical and public health problem, as well as the major milestones and setbacks in the ongoing quest to understand the wide variety of cancers that continue to impact the world. Subsequent chapters then address pathogenesis, incidence and mortality statistics, risk factors, causal factors, screening challenges and victories, treatment strategies, and disease prevention approaches. This wealth of clinical information is further supplemented with socioeconomic discussions on the financial, social, ethical, technological, regulatory, political, and logistical challenges that limit progress in cancer research. A soon to be gold-standard text that thoroughly and expertly describes cancer as a composite, adaptive system, Cancer: The Enemy from Within equips and empowers all undergraduate students and graduate students to better understand this continually perplexing disease. Clinicians across all disciplines may also find this work of great interest.

The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field. Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows. It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth. The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease. The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease. The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving. Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community. It is written not only for consultation, but also for easy cover-to-cover reading.

An unprecedented constellation of experts—leading cancer doctors, policymakers, cutting-edge researchers, national advocates, and more—explore the legacy and the shortcomings from the fifty-year war on cancer and look ahead to the future. The longest war in the modern era, longer than the Cold War, has been the war on cancer. Cancer is a complex, evasive enemy, and there was no quick victory in the fight against it. But the battle has been a monumental test of medical and scientific research and fundraising acumen, as well as a moral and ethical challenge to the entire system of medicine. In A New Deal for Cancer, some of today’s leading thinkers, activists, and medical visionaries describe the many successes in the long war and the ways in which our deeper failings as a society have held us back from a more complete success. Together they present an unrivaled and nearly complete map of the battlefield across dimensions of science, government, equity, business, the patient provider experience, and more, documenting our emerging understanding of cancer’s many unique dimensions and offering bold new plans to enable the American health care system to deliver progress and hope to all patients.

Why do we get cancer? Is it our modern diets and unhealthy habits? Chemicals in the environment? An unwelcome genetic inheritance? Or is it just bad luck? The answer is all of these and none of them. We get cancer because we can't avoid it—it's a bug in the system of life itself. Cancer exists in nearly every animal and has afflicted humans as long as our species has walked the earth. In Rebel Cell: Cancer, Evolution, and the New Science of Life's Oldest Betrayal, Kat Arney reveals the secrets of our most formidable medical enemy, most notably the fact that it isn't so much a foreign invader as a double agent: cancer is hardwired into the fundamental processes of life. New evidence shows that this disease is the result of the same evolutionary changes that allowed us to thrive. Evolution helped us outsmart our environment, and it helps cancer outsmart its environment as well—alas, that environment is us. Explaining why "everything we know about cancer is wrong," Arney, a geneticist and award-winning science writer, guides readers with her trademark wit and clarity through the latest research into the cellular mavericks that rebel against the rigid biological "society" of the body and make a leap towards anarchy. We need to be a lot smarter to defeat such a wily foe—smarter even than Darwin himself. In this new world, where we know that every cancer is unique and can evolve its way out of trouble, the old models of treatment have reached their limits. But we are starting to decipher cancer's secret evolutionary playbook, mapping the landscapes in which these rogue cells survive, thrive, or die, and using this knowledge to predict and confound cancer's next move. Rebel Cell is a story about life and death, hope and hubris, nature and nurture. It's about a new way of thinking about what this disease really is and the role it plays in human life. Above all, it's a story about where cancer came from, where it's going, and how we can stop it.

A breakthrough guide for cancer patients on using the mind to treat the body, from a pioneer in complementary medicine Recent research has shown that the mind can make a tremendous difference in not only the daily experience of living with cancer but also in the potential for overcoming it. In this groundbreaking book, Dr. Martin L. Rossman-hailed as "one of the greatest healers of our generation" by Rachel Naomi Remen-shows cancer patients how to use imagery in specific ways that can help them in their fight against cancer. Imagery is a natural, efficient way of storing and processing information, and one that has powerful effects on both emotional states and physiology. And while imagery is not a substitute for medical, surgical, or other physical approaches to cancer therapy, scientific studies have proven that it complements and enhances those treatments in many important ways. In this first book of its kind, Rossman provides specific ways to use imaging in fighting cancer. Praise for Guided Imagery for Self-Healing: "This superb collection of imagery techniques is a landmark contribution to the emerging field of behavioral medicine." -Joan Borysenko, Ph.D., author of Minding the Body, Mending the Mind

A provocative and surprising investigation into the ways that profit, personalities, and politics obstruct real progress in the war on cancer—and one doctor's passionate call to action for change This year, nearly 1.6 million new cases of cancer will be diagnosed and more than 1,500 people will die per day. We've been asked to accept the disappointing strategy to "manage cancer as a chronic disease." We've allowed pharmaceutical companies to position cancer drugs that extend life by just weeks and may cost $100,000 for a single course of treatment as breakthroughs. Why have we been able to cure and prevent other killer diseases but not most cancers? Where is the bold government leadership that will transform our system from treatment to prevention? Have we forgotten the mission of the National Cancer Act of 1971, to "conquer cancer"? Through an analysis of over 40 years of medical evidence and interviews with cancer doctors, researchers, drug company executives, and health policy advisors, Dr. Cuomo reveals frank and intriguing answers to these questions. She shows us how all cancer stakeholders—the pharmaceutical industry, government, physicians, and concerned Americans—can change the way we view and fight cancer in this country.

Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

BOOK SUMMARY Metastatic Madness is a collection of poems and the recollections of the author’s experience with a first time cancer diagnosis. The book describes the author’s five phases of coping with this diagnosis, from initial shock to adjusting to and becoming a strong advocate for herself and others. Soon after discovering a thickening in her left breast, the author learned she was at Stage 4 breast cancer. Despite previous negative screening and test results, she now has an incurable form of the disease. Following several months of chemotherapy and surgery, she went into remission of her illness. Since then, she has developed the strength and will to face an illness that has an average life span of three to five years. The author’s intent is to share her experience with others who may be struggling with a cancer diagnosis, and hopefully, give them strategies to improve the quality of their lives. AUTHOR BIOGRAPHY Carol A. Miele retired from nursing after a 45 year nursing career. Growing up in Old Forge, Pennsylvania, she graduated from Community Medical Center School of Nursing in 1965, received a BS Degree in Nursing Education at Wilkes College in 1977 and a Masters of Public Health at East Stroudsburg University in 2000. The author enjoyed many roles in nursing: Medical-Surgical, Psychiatric, Operating Room, Emergency Room, Recovery Room and Intensive Care Unit clinical nurse. Also. She was an Occupational Health Nurse, Nursing Instructor, Assistant Director of Nurses, and Quality/Risk Manager in the hospital, home care, hospice and residential environments. Diagnosed with Stage 4 Breast Cancer and metastasis to bone in October 2010, she went into remission in June 2011 following months of Chemotherapy. Enjoying her stable condition, she lives with her husband and dog Flora in Ocala, FL. They have two married daughters, Marisa Grier and Kristen Miele Beatty.

"The author, a researcher in oncology, studies the cellular mechanisms of carcinogenesis. In this book written for a popular audience, the author takes a step back from the details of cells to look at the broader issue of how aging affects cancer"--