Cancer Screening and Genetics is reviewed extensively in this important Surgical Clinics of North America issue. Articles include: Cancer Genetics and Implications for Clinical Management; Epigenetics and Cancer; Screening and Early Detection of Cancer: Successes and Failures; Screening for Lung Cancer; Screening for Breast Cancer; Viral Hepatitis and Hepatocellular Cancer: How Should Patients Be Screened?; Screening for Pancreatic Cancer: Where Do We Stand?; Hereditary Colorectal Cancer: Genetics and Screening; Personalized Approach to Gastrointestinal Cancers; Screening for Colorectal Cancer; Screening for Prostate Cancer: Why the Controversy?; Gastric Cancer: East versus West—Is screening and early detection the difference?; and more!

Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.

Morrison (human genetics, University of Ulster, UK) and Spence (biomedical science, University of Ulster, UK) offer an accessible reference on the genetic disorders that surgeons can expect to meet in general surgical practice. Written in non-technical language, with a glossary, list of abbreviations, and color and b&w photos and medical images, the book supplies an introduction to the nomenclature and technology of molecular biology, and will be a useful starting point for those who wish to extend their knowledge. Annotation :2005 Book News, Inc., Portland, OR (booknews.com).

Written by a world-recognized leader in this emerging field, Clinical Cancer Genetics provides an updated and expanded treatment of Kenneth Offit's seminal text on the clinical management associated with syndromes of cancer predisposition, with a thorough review of the relevant molecular genetics. This second edition features new coverage of pharmacogenetics, gene therapy trials, high throughput genotyping, and microarrays and includes a new focus on epigenetic events in carcinogenesis within background chapter on cancer genetics. Expanded coverage highlights more uncommon and rare cancer predisposition syndromes.

Contributors. -- Foreword. -- Preface. -- Getting Started. -- Assessing Available Information. -- Organizing and Preliminary Planning for Surgical Research -- Writing a Protocol: Animals, Humans, and Use of Biologic, Chemical, and Radiologic Agents. -- Grantsmanship. -- Informed Consent and the Protection of Human Research Subjects: Historical Perspectives and Guide to Current United States Regulations. -- Animal Care and Maintenance. -- Funding Strategies and Agencies: Academic-Industrial Relationships; Intellectual Property. -- Statistical Considerations. -- Use of Nonexperimental Studies to Evaluate Surgical Procedures and Other Interventions: The Challenge of Risk Adjustment. -- Measuring Surgical Outcomes. -- Design of Clinical Trials. -- Using Administrative Data for Clinical Research. -- Research in the Intensive Care Unit: Ethical and Methodological Issues. -- Research in the Operating Room. -- Effects of Age and Gender. -- Strategies, Principles, and Techniques Using Transgeni ...

This issue of Surgical Clinics of North America focuses on Surgical Oncology for the General Surgeon and is edited by Drs. Neal Wilkinson and Randall Zuckerman. Articles will include: Cancer Incidence and Trends; Cancer Genetics; Imaging and Interventional Radiology for Cancer Management; Esophagus and GE Junction Tumors; Gastric Cancer; Primary Liver Cancers; Metastatic Cancer to Liver; Pancreas Solid Tumors; Pancreas Cystic Lesions; Peritoneal Cancers and HIPEC; Rectal Cancer; Anal Cancer; Neuroendocrine Tumors; Soft Tissue Tumors of the Abdomen; Soft Tissue Tumors of the Extremities; and more!

This issue of Surgical Clinics of North America focuses on Contemporary Melanoma Management: A Surgical Perspective, and is edited by Dr. Rohit Sharma. Articles will include: Melanoma etiology and risk factors; Genetic, inherited and familial melanoma; Staging melanoma: What's old and new; Surgical management of primary cutaneous melanoma; Surgical management of regional lymph nodes in melanoma; Non-surgical management of regional lymph nodes in melanoma; Principles of immunotherapy in melanoma; Principles of targeted therapy in melanoma; Role of radiation in the era of effective systemic therapy for melanoma; Melanoma of unusual sites; Ongoing clinical trials in melanoma; Role of surgery for metastatic melanoma; Surgical considerations and systemic therapy of melanoma; Management of loco regionally advanced melanoma; Pathology of melanoma; and more!

This issue of Surgical Clinics of North America focuses on Management of Breast Cancer, and is edited by Dr. Catherine C. Parker. Articles will include: Screening mammography: recommendations and controversies; High risk breast cancer patients: genetics and indications for prophylactic mastectomy; Incorporation of biologic factors into breast cancer staging; Impact of advancing technology on diagnosis and treatment of breast cancer; Ductal Carcinoma In Situ; Management of the axilla in the patient with breast cancer; Definition and management of positive margins for invasive breast cancer; Neoadjuvant chemotherapy for HER2-positive and triple negative breast cancer; Inflammatory breast cancer; Role of radiation in breast cancer; Breast cancer in the elderly; Evolution of operative technique for mastectomy; Breast reconstruction; Role of operative management in Stage IV breast cancer; Sarcomas of the breast; and more!

Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.

Perioperative Management is reviewed extensively in this important Surgical Clinics of North America issue. Articles include: Cardiac risk stratification and protection; Prevention of pulmonary complications; Perioperative nutrition; Prophylactic antibiotics and prevention of post-operative infections; DVT and VTE prophylaxis; Post-operative pain control and sedation; End points of resuscitation; Optimal glucose management in the perioperative period; Essentials of sepsis management; Transfusion and management of surgical patients with hematologic disorders; Perioperative management of the obese patient; Perioperative management of the elderly patient; Perioperative management in the patient with substance abuse; Management of the pregnant patient undergoing general surgical procedures; Advanced directives, living wills and futility; and more!