Derived from the acclaimed online “WormAtlas,†C. elegansAtlas is a large-format, full-color atlas of the hermaphroditic form of the model organism C. elegans, known affectionately as “the worm†by workers in the field. Prepared by the editors of the WormAtlas Consortium, David H. Hall and Zeynep F. Altun, this book combines explanatory text with copious, labeled, color illustrations and electron micrographs of the major body systems of C. elegans. Also included are electron microscopy cross sections of the worm. This laboratory reference is essential for the working worm biologist, at the bench and at the microscope, and provides a superb companion to the C. elegansII monograph. It is also a valuable tool for investigators in the fields of developmental biology, neurobiology, reproductive biology, gene expression, and molecular biology.

Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR

The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases Examples of the use of mouse models in the study of neurological illness

It takes many cell divisions to produce a complex, multicellular organism such as a human being. Every one of the trillions of cells in a human body was produced by the division of a parent cell, which in turn was produced by the division of its parent; and if one follows this lineage far back enough, one will reach the single zygote cell that is the common progenitor of all of the cells in the body. Collectively, the pattern of cell divisions that produce an organism is called its cell lineage. As cells divide in a developing organism, they also differentiate into specialized cell types. What cell type a cell will adopt-its "cell fate"-is restricted by its lineage. A cell that descends from an endoderm progenitor, for example, may differentiate into a liver cell or an intestine cell, but will not become a bone cell. This general principle, that different parts of an organism's cell lineage have different developmental potentials, has been known since the early 1800s. But our understanding of the molecular mechanisms that connect the cell lineage to the process of cell differentiation remains incomplete. In this dissertation, I present a near-comprehensive atlas of gene expression in the embryonic cell lineage of the nematode Caenorhabditis elegans, the only animal for which the cell lineage is fully known. I describe the methods used to assemble this atlas from single cell RNA-seq data, which required finding the precise lineage identity of each assayed cell. Using the atlas, I investigate the molecular mechanisms of cell fate commitment, finding that: 1. Multilineage priming is strikingly prevalent, contributing to the differentiation of over half of the cells in the lineage. 2. Distinct lineages that produce the same anatomical cell type tend to converge to a homogenous transcriptional state. This convergence is gradual for lineages that commit to their cell fate early in development, but can be abrupt for lineages that commit late. 3. A cell's lineage and its transcriptome are correlated, but this correlation is transient, peaking in late gastrulation and falling dramatically during terminal differentiation. 4. Developmental trajectories reconstructed from single cell RNA-seq data often do not accurately reflect the cell lineage, in large part due to the transcriptional convergence of similarly fated lineages. Supplementary datasets, e.g. from fluorescent reporter imaging, are necessary to accurately place single cell RNA-seq data in the context of the cell lineage. This work provides an extensive resource to the C. elegans research community and an outline of the challenges that will need to be overcome in future studies of vertebrate cell lineages by single cell RNA-seq.

This atlas contains 189 coloured images taken from transversal, horizontal and sagittal sections of eleven organisms widely used in university teaching. Six invertebrate and five vertebrate species – from the nematode worm (Ascaris suum) to mammals (Rattus norvegicus) – are shown in detailed images. Studying the macrosections with unaided eyes, with a simple magnifier or binocular microscope might be of great help to accomplish traditional anatomical studies and to establish a certain spatial experience/space perception. This volume will be of great interest for biology students, researchers and teachers of comparative anatomy. It might act as supporting material of practical courses. Furthermore, medical practitioners, agricultural specialists and researchers having an interest in comparative anatomy might also benefit from it.

Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely

Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p

A lavishly illustrated guide to almost 200 inherited diseases of the skin, hair, and nails. Each entry includes synonyms, age of onset, clinical findings, complications, course, laboratory findings, diagnosis, therapy, and key references, adding up to far more than just a collection of photographs. In addition to being a clinical primer, this is also a work of scientific research and contains the first printed description of two new syndromes. The fast-moving world of genetic research means that the latest genetic correlations, included here, render previous texts out of date. All specialists in Dermatology and Pediatrics should find this an invaluable front-line resource in the clinic.

Written in the 1840s and published here for the first time, Julia Ward Howe's novel about a hermaphrodite is unlike anything of its time--or, in truth, of our own. Narrated by Laurence, who is raised and lives as a man, is loved by men and women alike, and can respond to neither, this unconventional story explores the understanding "that fervent hearts must borrow the disguise of art, if they would win the right to express, in any outward form, the internal fire that consumes them." Laurence describes his repudiation by his family, his involvement with an attractive widow, his subsequent wanderings and eventual attachment to a sixteen-year-old boy, his own tutelage by a Roman nobleman and his sisters, and his ultimate reunion with his early love. His is a story unique in nineteenth-century American letters, at once a remarkable reflection of a largely hidden inner life and a richly imagined tale of coming of age at odds with one's culture. Howe wrote "The Hermaphrodite" when her own marriage was challenged by her husband's affection for another man--and when prevailing notions regarding a woman's appropriate role in patriarchal structures threatened Howe's intellectual and emotional survival. The novel allowed Howe, and will now allow her readers, to occupy a speculative realm otherwise inaccessible in her historical moment.