Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume, concentrates on the brain transcriptome. - Brings together cutting-edge research on the brain transcriptome

The previous two editions of the Human Nervous System have been the standard reference for the anatomy of the central and peripheral nervous system of the human. The work has attracted nearly 2,000 citations, demonstrating that it has a major influence in the field of neuroscience. The 3e is a complete and updated revision, with new chapters covering genes and anatomy, gene expression studies, and glia cells. The book continues to be an excellent companion to the Atlas of the Human Brain, and a common nomenclature throughout the book is enforced. Physiological data, functional concepts, and correlates to the neuroanatomy of the major model systems (rat and mouse) as well as brain function round out the new edition. - Adopts standard nomenclature following the new scheme by Paxinos, Watson, and Puelles and aligned with the Mai et al. Atlas of the Human Brain (new edition in 2007) - Full color throughout with many new and significantly enhanced illustrations - Provides essential reference information for users in conjunction with brain atlases for the identification of brain structures, the connectivity between different areas, and to evaluate data collected in anatomical, physiological, pharmacological, behavioral, and imaging studies

The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases Examples of the use of mouse models in the study of neurological illness

This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.

This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.

More children born today will survive to adulthood than at any time in history. It is now time to emphasize health and development in middle childhood and adolescence--developmental phases that are critical to health in adulthood and the next generation. Child and Adolescent Health and Development explores the benefits that accrue from sustained and targeted interventions across the first two decades of life. The volume outlines the investment case for effective, costed, and scalable interventions for low-resource settings, emphasizing the cross-sectoral role of education. This evidence base can guide policy makers in prioritizing actions to promote survival, health, cognition, and physical growth throughout childhood and adolescence.

This is the first English-language publication of the complete works of the great Spanish neurohistologist, Santiago Ramon y Cajal, on the cerebral cortex. The new translations include all Cajal's very early contributions on the cortex of small mammals, relevant chapters from his definitive textbook, and all his great works on the human cerebral cortex made at the peak of his career. The book also presents Cajal's surveys of cortical structure dating from his later years. It is extensively annotated, and the editors have verified and completed all Cajal's references. Special introductory chapters review the state of knowledge during each period covered, and the work concludes with an extensive essay on modern cortical neurohistology in which the quality and lasting significance of Cajal's contributions are highlighted.

This book presents a new, detailed examination that explains how elegant brains have been shaped in evolution. It consists of 19 chapters written by academic professionals in neuroscience, opening with the origin of single-celled creatures and then introducing primordial types in invertebrates with the great abundance of the brains of vertebrates. Important topics are provided in a timely manner, because novel techniques emerged rapidly—as seen, for examples, in the next-generation sequencers and omics approaches. With the explosion of big data, neural-related genes and molecules is now on the radar. In fact, Europe’s big science and technology projects, a €1 billion plan called the Human Brain Project and the Blue Brain Project to understand mammalian brain networks, have been launched in recent years. Furthermore, with the rise of recently advanced artificial intelligence, there is great enthusiasm for understanding the evolution of neural networks. The views from brain evolution in nature provide an essential opportunity to generate ideas for novel neuron- and brain-inspired computation. The ambition behind this book is that it will stimulate young scientists who seek a deeper understanding in order to find the basic principles shaping brains that provided higher cognitive functions in the course of evolution.

Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.