Brain Hypoxia And Ischemia New Insights Into Neurodegeneration And Neuroprotection
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Author |
: Natalia N Nalivaeva |
Publisher |
: Frontiers Media SA |
Total Pages |
: 162 |
Release |
: 2019-11-15 |
ISBN-10 |
: 9782889631179 |
ISBN-13 |
: 2889631176 |
Rating |
: 4/5 (79 Downloads) |
Synopsis Brain Hypoxia and Ischemia: New Insights Into Neurodegeneration and Neuroprotection by : Natalia N Nalivaeva
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author |
: Matilde Otero-Losada |
Publisher |
: Frontiers Media SA |
Total Pages |
: 114 |
Release |
: 2019-08-30 |
ISBN-10 |
: 9782889459544 |
ISBN-13 |
: 2889459543 |
Rating |
: 4/5 (44 Downloads) |
Synopsis Neuroprotection in Brain Hypoxia by : Matilde Otero-Losada
Despite compelling preclinical evidence from laboratory models of brain hypoxia suggesting potential neuroprotective strategies, only scattered data are available from clinical studies. A few candidate neuroprotectants have been studied regarding antioxidant, antiapoptotic, anti-excitotoxic, immunomodulatory, and neurotrophic effects. In parallel with clinical innovations, preclinical research initiatives are also identifying new animal models more closely resembling the clinical course and pathology of neurodegenerative diseases. Clarifying the specific mission of the brain cells involved in the damage/repair system in the examined animal models is important to define new therapeutic targets. Following hypoxic damage, detrimental events intermingle with the repairing events in both time- and cellular-dependent fashion. Identifying reliable post-hypoxia brain markers is mandatory to develop potential therapeutic interventions, improving translational research from the experimental observations to the clinical application. A deeper understanding of the precise participation of neurons, glia, and endothelial cells is expected to offer more clues for designing new therapeutic strategies to reduce the current gap among the experimental and the clinical data. One of the main issues should be to study the epigenetic mechanism of neuroprotective agents and their action on the genetic modification induced by hypoxia. Achieving this goal is presumed critical to obtain more conclusive results in patients that by now do not receive appropriate therapy for mitigating the several diseases generated by brain hypoxia. Although a few ongoing studies are evaluating interesting approaches, future research is necessary to come to a novel mechanism of neuroprotection. This book encompasses different chapters conveying the goals and aims of the pertaining research.
Author |
: |
Publisher |
: ScholarlyEditions |
Total Pages |
: 196 |
Release |
: 2013-07-22 |
ISBN-10 |
: 9781481663618 |
ISBN-13 |
: 1481663615 |
Rating |
: 4/5 (18 Downloads) |
Synopsis Brain Ischemia: New Insights for the Healthcare Professional: 2013 Edition by :
Brain Ischemia: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Additional Research. The editors have built Brain Ischemia: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Additional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Brain Ischemia: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author |
: Gabriel G. Haddad |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 363 |
Release |
: 2009-01-06 |
ISBN-10 |
: 9781603275798 |
ISBN-13 |
: 1603275797 |
Rating |
: 4/5 (98 Downloads) |
Synopsis Brain Hypoxia and Ischemia by : Gabriel G. Haddad
Brain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia. Chapters focus on a panorama of issues including the role of ion channels/transporters, mitochondria and apoptotic mechanisms, the roles of glutamate/NMDA, mechanisms in penumbral cells and the importance of intermittent hypoxia and gene regulation under these stressful conditions. The volume explores findings from both mammalian and invertebrate model systems and their applicability to human systems and diseases. Careful consideration is also given to differences in hypoxia and ischemia across development. This volume aims to increase the understanding of these mechanisms and to stimulate research on better diagnosis and treatment of diseases that afflict the brain and potentially other organs when O2 levels are dysregulated. Brain Hypoxia and Ischemia is designed for neuroscientists, clinicians and medical/graduate students for use in both basic research and clinical practice.
Author |
: Eetu Hämäläinen |
Publisher |
: Nova Publishers |
Total Pages |
: 332 |
Release |
: 2008 |
ISBN-10 |
: 1604561408 |
ISBN-13 |
: 9781604561401 |
Rating |
: 4/5 (08 Downloads) |
Synopsis New Trends in Brain Hypoxia Ischemia Research by : Eetu Hämäläinen
This book presents recent and significant research from around the world dedicated to brain hypoxia-ischemia which is a disorder characterised by a reduction in oxygen supply (hypoxia) combined with reduced blood flow (ischemia) to the brain. This condition may result from a localised obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ischemic attack, transient; brain infarction; brain edema; coma; and other conditions.
Author |
: Koji Shimoji |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 166 |
Release |
: 2012-12-06 |
ISBN-10 |
: 9784431684671 |
ISBN-13 |
: 4431684670 |
Rating |
: 4/5 (71 Downloads) |
Synopsis Molecular Biology and Brain Ischemia by : Koji Shimoji
The latest advances in molecular neurobiology have contributed significantly to understanding the pathophysiology of brain ischemia/hypoxia and have led to more effective measures to protect against ischemic brain damage. An especially important feature of this book is the new insight it provides into the molecular neurobiology of neurotransmission, the functional structures of glutaminergic receptors, the functional proteins of synapses, and synaptic plasticity. Recent progress is reported in elucidating the pathophysiological roles of NO, free radicals, and intracellular pH and calcium ions in brain ischemia/hypoxia, and a unique approach for protective and therapeutic measures against this condition is described. Molecular Neurobiology and Brain Ischemia will be of special interest to researchers and practitioners in neurobiology and related fields, including neurosurgeons.
Author |
: Océane M. Roux |
Publisher |
: Nova Publishers |
Total Pages |
: 314 |
Release |
: 2008 |
ISBN-10 |
: 1604561394 |
ISBN-13 |
: 9781604561395 |
Rating |
: 4/5 (94 Downloads) |
Synopsis Brain Hypoxia-Ischemia Research Progress by : Océane M. Roux
Brain hypoxia-ischemia is a disorder characterised by a reduction in oxygen supply (hypoxia) combined with reduced blood flow (ischemia) to the brain. This condition may result from a localised obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ischemic attack, transient; brain infarction; brain oedema; coma; and other conditions. This book presents the latest research in this field from around the world.
Author |
: Paul J. Marangos |
Publisher |
: |
Total Pages |
: 392 |
Release |
: 1992 |
ISBN-10 |
: UOM:39015025228423 |
ISBN-13 |
: |
Rating |
: 4/5 (23 Downloads) |
Synopsis Emerging Strategies in Neuroprotection by : Paul J. Marangos
Reviews aspects of the search for drugs that will prevent the death of nerve cells after trauma to the brain, stroke, or such diseases as Alzheimer's and Parkinson's. Clinicians in the neurosciences may find helpful the descriptions of drugs already available; the material should also interest resea
Author |
: Hugo Lagercrantz |
Publisher |
: Cambridge University Press |
Total Pages |
: 427 |
Release |
: 2010-01-07 |
ISBN-10 |
: 9781139485586 |
ISBN-13 |
: 113948558X |
Rating |
: 4/5 (86 Downloads) |
Synopsis The Newborn Brain by : Hugo Lagercrantz
Development of the brain and the emergence of the mind constitute some of the most important concerns of contemporary biology. Disturbances during fetal life may have profound implications for a child's future neurological and psychological development, which can in turn impact society. The new edition of this highly respected work presents a comprehensive review of the basic mechanisms of brain development and the pathophysiology of disorders of the infant brain, written by a team of distinguished neuroscientists, neonatologists, and neuropediatricians. The book follows the main milestones of brain development, from formation of the neural tube and wiring of the neurons in the brain. Neurotrophic factors, neurotransmitters, glial cell biology, cerebral circulation development of sensory functions are all described in detail. Furthermore, there are more philosophical chapters on the evolution of the brain and the emergence of consciousness. Clinical considerations are highlighted where relevant.
Author |
: Pardeep Kumar |
Publisher |
: Academic Press |
Total Pages |
: 460 |
Release |
: 2021-06-13 |
ISBN-10 |
: 9780128217818 |
ISBN-13 |
: 0128217812 |
Rating |
: 4/5 (18 Downloads) |
Synopsis Machine Learning, Big Data, and IoT for Medical Informatics by : Pardeep Kumar
Machine Learning, Big Data, and IoT for Medical Informatics focuses on the latest techniques adopted in the field of medical informatics. In medical informatics, machine learning, big data, and IOT-based techniques play a significant role in disease diagnosis and its prediction. In the medical field, the structure of data is equally important for accurate predictive analytics due to heterogeneity of data such as ECG data, X-ray data, and image data. Thus, this book focuses on the usability of machine learning, big data, and IOT-based techniques in handling structured and unstructured data. It also emphasizes on the privacy preservation techniques of medical data. This volume can be used as a reference book for scientists, researchers, practitioners, and academicians working in the field of intelligent medical informatics. In addition, it can also be used as a reference book for both undergraduate and graduate courses such as medical informatics, machine learning, big data, and IoT. - Explains the uses of CNN, Deep Learning and extreme machine learning concepts for the design and development of predictive diagnostic systems. - Includes several privacy preservation techniques for medical data. - Presents the integration of Internet of Things with predictive diagnostic systems for disease diagnosis. - Offers case studies and applications relating to machine learning, big data, and health care analysis.