Aspiring scientist Arabella Holmes doesn't fit the role of a 1900s lady. Her father, Sherlock, landed her a position at the Mütter Museum to pursue her dream of becoming a purveyor of abnormal science, or what her father calls a "Boneseeker." Henry Watson’s two-fold mission at the Mütter Museum is to join their team of forensic anthropologists in unearthing unusual antiquities and to watch over Arabella. If only he could get her to speak to him, instead of hurling knives in his general direction. Assigned to a most secret expedition to investigate a mysterious skeletal hand discovered in upstate New York, Arabella and Henry are soon caught in a scientific debate, and the search for the truth may have deadly consequences for those involved. Are the bones from a Neanderthal? Or are they living proof of fallen angels known as Nephilim? Watson and Holmes must put aside their differences, trust their instincts, and rely on one another to survive to uncover the truth. *This is a new version of a previously published edition

Arabella Holmes--yes, daughter of that Holmes--wants to return to her job as a purveyor of abnormal science. She has temporarily been demoted to a botanist, until her love interest, Henry Watson--yes, that Watson--can help her get her less-than-professional outbursts in check. Henry is tired of his new role as doctor, tired of the lack of adventure, and tired of keeping Bella's escapades out of the papers. Five girls are missing. Gone from locked rooms in their own houses. Arabella and Henry are called upon to help solve the kidnappings, but all they unearth is more danger. Bella ventures undercover into a lunatic asylum, where a mute woman assaults her and scrawls the chilling words—Here the dead wake. Plus, a vial of Bella's research poison has gone missing. Bella and Henry must find it, and the missing girls, before charges can be brought against her.

"Summer school is in session on Ellesmere Island, and Martha, one of Edie Kiglatuk's students, is missing. When Martha's body turns up in Lake Turngaluk, Edie and her sidekick, Derek Palliser, promise the grieving family they'll deliver justice. But Martha's deeply traditional Inuit father spurns them as outsiders. Meanwhile, bullheaded lawyer Sonia Gutierrez is on her own crusade to investigate Lake Turngaluk's decades-old toxicity. Was one of the soldiers stationed near the lake involved in Martha's murder? Or is a larger conspiracy afoot--one involving the Canadian government? Edie, Sonia, and Derek clamber over the rocky Arctic terrain under the twenty-four-hour summer sun to find Martha's killer, but not without risking their own lives in the pursuit."--Back cover.

This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs. Bisphosphonates in Bone Disease, Fourth Edition, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revised Fourth Edition contains approximately 50% new material, including information on all of the latest drugs. - The revised fourth edition contains approximately 50% new material - Includes information on all the latest drugs

Testing on animals has become standard practice for evaluating the potential efficacy of therapeutic or diagnostic agents. Not only are the overhead costs of such testing extremely high, but subjecting substantial numbers of animals to intensive testing and re-testing raises serious ethical questions and is widely unpopular with the public. This study explores the advantages of combining various analytical methods with mathematical and computer modeling to construct a multifaceted tool for the pre-vivo screening of prospective radiopharmaceuticals. The benefits of such a method lie in cost minimization and the avoidance of the ethical dimension. The 117mSn radionuclide was identified as an ideal pharmacological component for the treatment of bone pain, and two tin-bisphosponate complexes - Sn(II)-APDDMP and Sn(IV)-PEI-MP were chosen for evaluation. This book describes how these complexes were studied using various techniques.

Includes all lectures presented at the NATO ASI Course on title] held in Erice, Sicily, May 1989. Covers morphological, chemical, biochemical, physiological and pathophysiological aspects of bone formation and resorption, focusing on regulatory factors and indicating the new directions that are ope

Locked up within human bone are tantalizing clues concerning the diets consumed by ancient peoples. On the one hand the amounts of certain elementsin bone (strontium, zinc) serve as measures of protein, fiber, and calcium intake. On the other hand, the ratios of carbon isotopes and of nitrogen isotopes provide information on questions of fish vs. meat, herbivore vs. carnivore, or (for animals) browser (shrubs) vs. grazer (grasses). Such information can provide a window on many aspects of prehistoric cultures and can supplement the nonskeletal archaeological record. In addition to these two approaches, the biochemical record in bone from protein and nucleic acids such as DNA serves as a source of nondietary information such as genetic relationships. This volume treats all three subjects.: elemental, isotopic, and biochemical. The foremost experts in the areas provide fundamental descriptions of the techniques, express their concerns over the limitations of the methods, and describe recent applications to archaeological studies.