A young woman walks alone through a barren landscape in a time before history, a time of cataclysmic natural change. She is cold, hungry and with child but not without hope or resources. A skilful hunter, she draws on her intuitive understanding of how to stay alive... and knows that she must survive. In present-day London, geneticist Dr Eloise Kluft wrestles with an ancient conundrum as she unravels the secrets of a momentous archaeological find. She is working at the forefront of contemporary science but is caught in the lonely time-lock of her own emotional past. Bone Lines is the story of two women, separated by millennia yet bound by the web of life. A tale of love and survival – of courage and the quest for wisdom – it explores the nature of our species and asks what lies at the heart of being human. Although partly set during a crucial era of human history 74,000 years ago, Bones Lines is very much a book for our times. Dealing with themes from genetics, climate change and migration to the yearning for meaning and the clash between faith and reason, it also paints an intimate portrait of who we are as a species. The book tackles some of the big questions but requires no special knowledge of any of the subjects to enjoy. Alternating between ancient and modern timelines, the story unfolds through the experiences of two unique characters: One is a shaman, the sole surviving adult of her tribe who is braving a hazardous journey of migration, the other a dedicated scientist living a comfortable if troubled existence in London, who is on her own mission of discovery. The two are connected not only by a set of archaic remains but by a sense of destiny – and their desire to shape it. Both are pioneers, women of passion, grit and determination, although their day to day lives could not be more different. One lives moment by moment, drawing on every scrap of courage and ingenuity to keep herself and her infant daughter alive, while the other is absorbed by work, imagination and regret. Each is isolated and facing her own mortal dangers and heart-rending decisions, but each is inspired by the power of the life force and driven by love. Bone Lines stands alone as a novel but also marks the beginning of the intended ‘Children of Sarah’ series.

Proximal Humerus Fractures includes everything the orthopedic surgeon needs to know about the clinical management of these common shoulder injuries. Although non-operative treatment techniques are addressed and can be used in less severe circumstances, this book focuses mainly on the current operative treatment techniques for proximal humerus and tuberosity fractures, malunions and nonunions, including open reduction, percutaneous pinning, locking plate and intramedullary nail fixation, and humeral head hemiarthroplasty and reverse shoulder arthroplasty. A chapter on complications associated with these types of fractures and their management is also included. Dedicated to a common musculoskeletal injury, especially in athletes and the elderly suffering from osteoporosis, Proximal Humerus Fractures will be a valuable resource to all orthopedic surgeons and practitioners of sports medicine.

A version of the OpenStax text

First Published in 1982, this book offers a full, comprehensive guide into the methods and techniques used for the examination of bone. Carefully compiled and filled with a vast repertoire of notes, pictures, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.

Bone: A Treatise is a series of seven volumes devoted to providing the most up-to-date, comprehensive, and authoritative coverage of all aspects of bone. Seventy-four chapters have been written by 127 respected authors, all of whom are actively engaged in basic, applied, and clinical bone research. The seven volumes in this unique series are organized thematically; each volume integrates structure, function, biochemistry, metabolism, and the molecular and clinical aspects of a particular aspect of the biology of bone. Bone-forming cells are treated in Volume I. Bone resorbing cells are covered in Volume II. Volumes III and IV examine the extracellular matrix of bone, with Volume III concentrating on the structure of bone matrix and on bone-specific proteins, while Volume IV focuses on the mineralization (calcification) of that matrix. Volume V addresses the repair and regeneration of bone. Volumes VI and VII explore bone growth and development.

A comprehensive description of macroscopic, microscopic, and radiological methods for the diagnosis of bone diseases. The book presents all the procedures involved in diagnosis, using not only radiological and histological techniques, but also modern immunohistochemical and scintigraphic methods. Succinct and well-structured therapeutic recommendations are provided for an array of bone diseases, making this a practice-oriented reference work for pathologists, radiologists, rheumatologists, and orthopedists.

The Biochemistry and Physiology of Bone focuses on the advancements of techniques, methodologies, and approaches involved in bone studies, including general anatomy, tissues, collagen fibers, and calcification. The selection first offers information on the general anatomy and histology of bone and bone as a mechanical engineering problem. Topics include strength of healing fractures, nervous influences on bone, growth of the skull, bone strength, primary constituents of bony tissue, and types and organization of bony tissue. The text then elaborates on the ground substance of connective tissue and cartilage, organic matrix of bone, and collagen fibers of connective tissue. The publication takes a look at the ultrastructure and distribution of mineral salts in bone tissue, osteoblast, and osteoclast. Discussions focus on microscopical appearances, integration of morphological and histochemical studies, cytochemistry, distribution of inorganic salts in bone tissue, relation of collagen to its environment, and structure of collagen fibers. The publication also examines pathological calcification, effects of radiation on bone, parathyroid glands and bone, and anterior pituitary regulation of skeletal development. The selection is a dependable source of data for researchers interested in the biochemistry and physiology of bone.

Bone and Cartilage Engineering provides a complete overview of recent knowledge in bone and cartilage tissue engineering. It follows a logical approach to the various aspects of extracorporal bone and cartilage tissue engineering. The cooperation between a basic scientist and a clinician made it possible to structure the book's content and style according to the interdisciplinary character of the field. The comprehensive nature of the book, including detailed descriptions of laboratory procedures, preclinical approaches, clinical applications, and regulatory issues, will make it an invaluable basis for everyone working in this field. This book will serve as a fundamental tool for basic researchers to establish or refine tissue engineering techniques as well as for clinicians to understand and use this modern therapeutic option.