Examines biotechnology and related subjects in the context of science, government, politics, culture and society, and the environment. It also covers historical, political and ethical debates and issues.

Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.

The tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology. Industrialization of Biology presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, Industrialization of Biology identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.

This comprehensive 2007 survey of modern plant breeding traces its history from the earliest experiments at the dawn of the scientific revolution in the seventeenth century to the present day and the existence of high tech agribusiness. Murphy tells the story from the perspective of a scientist working in this field, offering a rationale and evidence-based insight into its development. Crop improvement is examined from both a scientific and socio-economic perspective and the ways in which these factors interact and impact on agricultural development are discussed, including debates on genetically-modified food. Murphy highlights concerns over the future of plant breeding, as well as potential options to enable us to meet the challenges of feeding the world in the 21st century. This thoroughly interdisciplinary and balanced account serves as an essential resource for everyone involved with plant breeding research, policy and funding, as well as those wishing to engage with current debates.

Between 1973 and 2016, the ways to manipulate DNA to endow new characteristics in an organism (that is, biotechnology) have advanced, enabling the development of products that were not previously possible. What will the likely future products of biotechnology be over the next 5â€"10 years? What scientific capabilities, tools, and/or expertise may be needed by the regulatory agencies to ensure they make efficient and sound evaluations of the likely future products of biotechnology? Preparing for Future Products of Biotechnology analyzes the future landscape of biotechnology products and seeks to inform forthcoming policy making. This report identifies potential new risks and frameworks for risk assessment and areas in which the risks or lack of risks relating to the products of biotechnology are well understood.

Genetic-based animal biotechnology has produced new food and pharmaceutical products and promises many more advances to benefit humankind. These exciting prospects are accompanied by considerable unease, however, about matters such as safety and ethics. This book identifies science-based and policy-related concerns about animal biotechnologyâ€"key issues that must be resolved before the new breakthroughs can reach their potential. The book includes a short history of the field and provides understandable definitions of terms like cloning. Looking at technologies on the near horizon, the authors discuss what we know and what we fear about their effectsâ€"the inadvertent release of dangerous microorganisms, the safety of products derived from biotechnology, the impact of genetically engineered animals on their environment. In addition to these concerns, the book explores animal welfare concerns, and our societal and institutional capacity to manage and regulate the technology and its products. This accessible volume will be important to everyone interested in the implications of the use of animal biotechnology.

How global biotechnology is redefining "life itself." In the age of global biotechnology, DNA can exist as biological material in a test tube, as a sequence in a computer database, and as economically valuable information in a patent. In The Global Genome, Eugene Thacker asks us to consider the relationship of these three entities and argues that—by their existence and their interrelationships—they are fundamentally redefining the notion of biological life itself. Biological science and the biotech industry are increasingly organized at a global level, in large part because of the use of the Internet in exchanging biological data. International genome sequencing efforts, genomic databases, the development of World Intellectual Property policies, and the "borderless" business of biotech are all evidence of the global intersections of biology and informatics—of genetic codes and computer codes. Thacker points out the internal tension in the very concept of biotechnology: the products are more "tech" than "bio," but the technology itself is fully biological, composed of the biomaterial labor of genes, proteins, cells, and tissues. Is biotechnology a technology at all, he asks, or is it a notion of "life itself" that is inseparable from its use in the biotech industry? The three sections of the book cover the three primary activities of biotechnology today: the encoding of biological materials into digital form—as in bioinformatics and genomics; its recoding in various ways—including the "biocolonialism" of mapping genetically isolated ethnic populations and the newly pervasive concern over "biological security"; and its decoding back into biological materiality—as in tissue engineering and regenerative medicine. Thacker moves easily from science to philosophy to political economics, enlivening his account with ideas from such thinkers as Georges Bataille, Georges Canguilhem, Michel Foucault, Antonio Negri, and Paul Virilio. The "global genome," says Thacker, makes it impossible to consider biotechnology without the context of globalism.

“Essential reading for anyone who wishes to understand the current state of biotechnology and the opportunities and dangers it may create.” —American Scientist Technology is a process and a body of knowledge as much as a collection of artifacts. Biology is no different—and we are just beginning to comprehend the challenges inherent in the next stage of biology as a human technology. It is this critical moment, with its wide-ranging implications, that Robert Carlson considers in Biology Is Technology. He offers a uniquely informed perspective on the endeavors that contribute to current progress in this area—the science of biological systems and the technology used to manipulate them. In a number of case studies, Carlson demonstrates that the development of new mathematical, computational, and laboratory tools will facilitate the engineering of biological artifacts—up to and including organisms and ecosystems. Exploring how this will happen, with reference to past technological advances, he explains how objects are constructed virtually, tested using sophisticated mathematical models, and finally constructed in the real world. Such rapid increases in the power, availability, and application of biotechnology raise obvious questions about who gets to use it, and to what end. Carlson’s thoughtful analysis offers rare insight into our choices about how to develop biological technologies and how these choices will determine the pace and effectiveness of innovation as a public good.

Universities throughout the US and the rest of the world offer Food Biotechnology courses. However, until now, professors lacked a single, comprehensive text to present to their students. Introduction to Food Biotechnology describes, explains, and discusses biotechnology within the context of human nutrition, food production, and food processing. Written for undergraduate students in Food Science and Nutrition who do not have a background in molecular biology, it provides clear explanations of the broad range of topics that comprise the field of food biotechnology. Students will gain an understanding of the methods and rationales behind the genetic modification of plants and animals, as well as an appreciation of the associated risks to the environment and to public health. Introduction to Food Biotechnology examines cell culture, transgenic organisms, regulatory policy, safety issues, and consumer concerns. It covers microbial biotechnology in depth, emphasizing applications to the food industry and methods of large-scale cultivation of microbes and other cells. It also explores the potential of biotechnology to affect food security, risks, and other ethical problems. Biotechnology can be used as a tool within many disciplines, including food science, nutrition, dietetics, and agriculture. Using numerous examples, Introduction to Food Biotechnology lays a solid foundation in all areas of food biotechnology and provides a comprehensive review of the biological and chemical concepts that are important in each discipline. The book develops an understanding of the potential contributions of food biotechnology to the food industry, and towards improved food safety and public health.