The release of nerve gas in the Tokyo subways, the spread of biological weapons, and the anthrax attack of 2001 in the United States demonstrate that not only is the threat of such menacing weapons real, but also that we must urgently prepare to deal with future acts of bioterrorism. In Biological Weapons Defense: Infectious Diseases and Counterbioterrorism, prominent experts in biodefense research-many from the US Army Medical Research Institute of Infectious Diseases-authoritatively delineate the universe of scientific, medical, and legal issues facing the biodefense research community. Regarding medical countermeasures and decontamination, the authors review the facts about both the aerosol route of infection and decontamination processes, and fully describe the pathogenesis and treatment of a variety of established pathogens (anthrax, plague, smallpox, Brucellosis, glanders, and Coxiella burnetii). They also examine how to discover the presence of these agents, or other previously unknown biological weapons, and the ongoing efforts to counter such agents, including proteomic and genomic analysis as a gateway to better diagnostics, therapeutics, vaccinations, genotyping, and forensics. Additional chapters discuss the development and use of technology to identify and characterize these infectious organisms and their emerging threats. Comprehensive and authoritative, Biological Weapons Defense: Infectious Diseases and Counterbioterrorism provides researchers, physicians, and policymakers with a sound basis for understanding not only the diseases caused by these infectious organisms, but also an appreciation of the universe of bioterrorism problems that must be mastered to develop effective countermeasures.

In recent years, substantial efforts have been initiated to develop new drugs, vaccines, and other medical interventions against biological agents that could be used in bioterrorist attacks against civilian populations. According to a new congressionally mandated report from the Institute of Medicine and National Research Council of the National Academies, to successfully develop these drugs, vaccines, and other medical interventions against biowarfare agents, Congress should authorize the creation of a new agency within the Office of the Secretary of the U.S. Department of Defense. The committee recommended that Congress should improve liability protections for those who develop and manufacture these products, to stimulate willingness to invest in new research and development for biowarfare protection. Giving Full Measure to Countermeasures also identifies other challengesâ€"such as the need for appropriate animal models and laboratories equipped with high-level biosafety protectionsâ€"that will require attention if DoD efforts to develop new medical countermeasures are to be successful.

Recent revelations about Iraqi and Soviet/Russian biological weapons programs and highly publicized events such as the deployment of anthrax and botulinum by the Aum Shinrikyo sect in Japan have made clear the necessity for addressing the issues of biological warfare and defense. In a comprehensive analysis of this imminent threat to global security, fourteen internationally recognized authorities consider the motivations of governments and terrorist groups seeking to acquire biological weapons; managing the consequences of a biological attack; techniques for weapons development; methods for detection of pathogens and toxins; defense against biological weapons; and international efforts to counter their proliferation.

This publication gives a history of biological warfare (BW) from the prehistoric period through the present, with a section on the future of BW. The publication relies on works by historians who used primary sources dealing with BW. In-depth definitions of biological agents, biological weapons, and biological warfare (BW) are included, as well as an appendix of further reading on the subject. Related items: Arms & Weapons publications can be found here: https://bookstore.gpo.gov/catalog/arms-weapons Hazardous Materials (HAZMAT & CBRNE) publications can be found here: https://bookstore.gpo.gov/catalog/hazardous-materials-hazmat-cbrne

The Gulf War has been the only conflict in the last half-century that featured the possible use of chemical-biological weapons against U.S. forces. Vulnerability to such an attack spurred the Department of Defense to action from the first hint of trouble in August 1990 through the end of hostilities in March 1991. Nearly disbanded in 1972, the U.S. Army Chemical Corps would be the prime force in ensuring that U.S. forces could both survive and sustain combat operations under chemical-biological warfare conditions. Focussing on the work of senior Army officials, this account assesses the degree of readiness achieved by the ground war's initiation and the lessons learned since the conflict. For an appropriately trained and equipped military force, chemical weapons pose not the danger of mass destruction but the threat of mass disruption, no more deadly than smart munitions or B-52 air strikes. This book will reveal a coordinated response to train and equip U.S. forces did take place prior to the feared Iraqi chemical and biological attacks. Undocumented in any other book, it details the plans that rushed sixty Fox reconnaissance vehicles to the Gulf, the worldwide call for protective suits and masks, and the successful placement of biological agent detectors prior to the air offensive. In addition, the work addresses what really happened at Khamisiyah. Were troops exposed to chemical weapons and what is behind the mysterious Gulf War Syndrome?

During the 1950s and 1960s, the U.S. Army conducted atmospheric dispersion tests in many American cities using fluorescent particles of zinc cadmium sulfide (ZnCdS) to develop and verify meteorological models to estimate the dispersal of aerosols. Upon learning of the tests, many citizens and some public health officials in the affected cities raised concerns about the health consequences of the tests. This book assesses the public health effects of the Army's tests, including the toxicity of ZnCdS, the toxicity of surrogate cadmium compounds, the environmental fate of ZnCdS, the extent of public exposures from the dispersion tests, and the risks of such exposures.

Handbook on Biological Warfare Preparedness provides detailed information on biological warfare agents and their mode of transmission and spread. In addition, it explains methods of detection and medical countermeasures, including vaccine and post-exposure therapeutics, with specific sections detailing diseases, their transmission, clinical signs and symptoms, diagnosis, treatment, vaccines, prevention and management. This book is useful reading for researchers and advanced students in toxicology, but it will also prove helpful for medical students, civil administration, medical doctors, first responders and security forces. As the highly unpredictable nature of any event involving biological warfare agents has given rise to the need for the rapid development of accurate detection systems, this book is a timely resource on the topic. - Introduces different bacterial and viral agents, including Ebola and other emerging threats and toxins - Discusses medical countermeasures, including vaccines and post-exposure therapeutics - Includes a comprehensive review of current methods of detection

Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.

In this “engrossing, well-documented, and highly readable” (San Francisco Chronicle) New York Times bestseller, three veteran reporters draw on top sources inside and outside the U.S. government to reveal Washington's secret strategies for combating germ warfare and the deadly threat of biological and chemical weapons. Today Americans have begun to grapple with two difficult truths: that there is no terrorist threat more horrifying—and less understood—than germ warfare, and that it would take very little to mount a devastating attack on American soil. Featuring an inside look at how germ warfare has been waged throughout history and what form its future might take (and in whose hands), Germs reads like a gripping detective story told by fascinating key figures: American and Soviet medical specialists who once made germ weapons but now fight their spread, FBI agents who track Islamic radicals, the Iraqis who built Saddam Hussein's secret arsenal, spies who travel the world collecting lethal microbes, and scientists who see ominous developments on the horizon. With clear scientific explanations and harrowing insights, Germs is a vivid, masterfully written—and timely—work of investigative journalism.

"Biological weapons are widely feared, yet rarely used. Biological weapons were the first weapon prohibited by an international treaty, yet the proliferation of these weapons increased after they were banned in 1972. Biological weapons are frequently called 'the poor man's atomic bomb,' yet they cannot provide the same deterrent capability as nuclear weapons. One of my goals in this book is to explain the underlying principles of these apparent paradoxes."—from Living Weapons Biological weapons are the least well understood of the so-called weapons of mass destruction. Unlike nuclear and chemical weapons, biological weapons are composed of, or derived from, living organisms. In Living Weapons, Gregory D. Koblentz provides a comprehensive analysis of the unique challenges that biological weapons pose for international security. At a time when the United States enjoys overwhelming conventional military superiority, biological weapons have emerged as an attractive means for less powerful states and terrorist groups to wage asymmetric warfare. Koblentz also warns that advances in the life sciences have the potential to heighten the lethality and variety of biological weapons. The considerable overlap between the equipment, materials and knowledge required to develop biological weapons, conduct civilian biomedical research, and develop biological defenses creates a multiuse dilemma that limits the effectiveness of verification, hinders civilian oversight, and complicates threat assessments. Living Weapons draws on the American, Soviet, Russian, South African, and Iraqi biological weapons programs to enhance our understanding of the special challenges posed by these weapons for arms control, deterrence, civilian-military relations, and intelligence. Koblentz also examines the aspirations of terrorist groups to develop these weapons and the obstacles they have faced. Biological weapons, Koblentz argues, will continue to threaten international security until defenses against such weapons are improved, governments can reliably detect biological weapon activities, the proliferation of materials and expertise is limited, and international norms against the possession and use of biological weapons are strengthened.